日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy

微调 BACH2 剂量可平衡干细胞特性和效应功能,从而增强抗肿瘤 T 细胞疗法。

Conti, Alberto G; Evans, Alexander C; von Linde, Teresa; Deguit, Christian Deo T; Whiteside, Sarah K; Wesolowski, Alexander J; Imianowski, Charlotte J; Yamashita-Kanemaru, Yumi; Dahmani, Layla; Chapman, Jack; Pillay, Ardon M; Al-Deka, Aws; Greaves, Randy; Burton, Oliver; Vardaka, Panagiota; Sampurno, Shienny; Pérez-Núñez, Iván; Saw, Nicole Y L; Yang, Jie; Howden, Andrew J M; Okkenhaug, Klaus; Mitra, Suman; Swiatczak, Bartlomiej; Parish, Ian A; Roychoudhuri, Rahul

High efficiency CRISPR knock-in demonstrates that TCF1 is insufficient to reverse T cell exhaustion.

高效的 CRISPR 基因敲入实验表明,TCF1 不足以逆转 T 细胞耗竭。

de Menezes Maria N, Chen Amanda X Y, Kulkarni Nihali, Sampurno Shienny, Saw Nicole Y L, Yap Kah Min, Pérez-Núñez Iván, Roth Sara, Deguit Christian Deo T, Haugen Brandon, Ramsbottom Kelly M, Munoz Isabelle, Beavis Paul A, Parish Ian A

A non-randomised open-label exploratory 'window of opportunity' study of TG02 treatment in patients with locally advanced primary and recurrent RAS mutant colorectal cancer

一项非随机、开放标签、探索性“机会窗口”研究,旨在评估TG02治疗局部晚期原发性和复发性RAS突变型结直肠癌患者的疗效。

Roth, Sara; Wilson, Kasmira Claire; Ramsay, Robert George; Mitchell, Catherine; Sampurno, Shienny; Pham, Toan Duc; Huei Kong, Joseph Cherng; Wong, Stephen Q; Heriot, Alexander Graham; Deva, Sanjeev; Burge, Matthew; Sverdrup, Cecilie; Moller, Anne-Sophie; Kuryk, Lukasz; Eriksen, Jon Amund; Jaderberg, Magnus; Zalcberg, John Raymond; Michael, Michael

The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects

CD8+ T细胞耐受检查点触发一种独特的细胞分化状态,该状态的特征是蛋白质翻译缺陷。

Willem Van Der Byl ,Simone Nüssing ,Timothy J Peters ,Antonio Ahn ,Hanjie Li ,Guy Ledergor ,Eyal David ,Andrew S Koh ,Mayura V Wagle ,Christian Deo T Deguit ,Maria N de Menezes ,Avraham Travers ,Shienny Sampurno ,Kelly M Ramsbottom ,Rui Li ,Axel Kallies ,Paul A Beavis ,Ralf Jungmann ,Maartje M C Bastings ,Gabrielle T Belz ,Shom Goel ,Joseph A Trapani ,Gerald R Crabtree ,Howard Y Chang ,Ido Amit ,Chris C Goodnow ,Fabio Luciani ,Ian A Parish

Human gene and microbial analyses in rectal cancer complete responses to radiotherapy

直肠癌对放射治疗完全缓解的人类基因和微生物分析

Sulit, Arielle Kae; Wilson, Kasmira; Pearson, John; Silander, Olin K; Sampurno, Shienny; Michael, Michael; Ramsay, Robert; Heriot, Alexander; Frizelle, Frank; Purcell, Rachel Violet

ASO Author Reflections: Humidification of Carbon Dioxide for Insufflation Offers Promise in Reducing Inflammation and Peritoneal Trauma During and Post Colorectal Cancer Surgery

ASO作者反思:二氧化碳加湿充气有望减少结直肠癌手术期间及术后的炎症和腹膜损伤

Ramsay, Robert; Sampurno, Shienny; Flood, Michael P; Lynch, Andrew C

Effect of Surgical Humidification on Inflammation and Peritoneal Trauma in Colorectal Cancer Surgery: A Randomized Controlled Trial

手术湿化对结直肠癌手术中炎症和腹膜损伤的影响:一项随机对照试验

Shienny Sampurno ,Timothy Chittleborough ,Meara Dean ,Michael Flood ,Sandra Carpinteri ,Sara Roth ,Rosemary M Millen ,Helen Cain ,Joseph C H Kong ,John MacKay ,Satish K Warrier ,Jacob McCormick ,Jonathon G Hiller ,Alexander G Heriot ,Robert G Ramsay ,Andrew C Lynch

Molecular and genomic characterisation of a panel of human anal cancer cell lines

人类肛门癌细胞系的分子和基因组表征

Glen R Guerra, Joseph C Kong, Rosemary M Millen, Matthew Read, David S Liu, Sara Roth, Shienny Sampurno, Joseph Sia, Maria-Pia Bernardi, Timothy J Chittleborough, Corina C Behrenbruch, Jiasian Teh, Huiling Xu, Nicole M Haynes, Jiaan Yu, Richard Lupat, David Hawkes, Natasha Di Costanzo, Richard W Tot

Modeling open surgery in mice to explore peritoneal damage, carbon dioxide humidification and desmoidogenesis

利用小鼠开放手术模型研究腹膜损伤、二氧化碳加湿和纤维瘤形成

Chittleborough, Timothy; Sampurno, Shienny; Carpinteri, Sandra; Lynch, Andrew Craig; Heriot, Alexander Graham; Ramsay, Robert George

First-in-human phase I clinical trial of a combined immune modulatory approach using TetMYB vaccine and Anti-PD-1 antibody in patients with advanced solid cancer including colorectal or adenoid cystic carcinoma: The MYPHISMO study protocol (NCT03287427)

首次人体 I 期临床试验,采用 TetMYB 疫苗和抗 PD-1 抗体联合免疫调节方法治疗晚期实体瘤(包括结直肠癌或腺样囊性癌)患者:MYPHISMO 研究方案 (NCT03287427)

Pham, Toan; Pereira, Lloyd; Roth, Sara; Galletta, Laura; Link, Emma; Akhurst, Tim; Solomon, Ben; Michael, Michael; Darcy, Phillip; Sampurno, Shienny; Heriot, Alexander; Ramsay, Robert; Desai, Jayesh