日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TET2 and TP53 Mutations Cooperatively Modulate the Response to Inflammation to Promote Leukemic Transformation

TET2 和 TP53 突变协同调节炎症反应,促进白血病转化。

Vela, Pablo Sánchez; Kelly, Brianna; Brady, Claudia; Foox, Jonathan; Glass, Jacob; Koche, Richard P; Wereski, Matthew; Csete, Isabelle; El Ghaity-Beckley, Sebastian; Marcellino, Bridget K; Levine, Ross L; Shih, Alan H

A novel 3-way translocation involving ETV6::IL3 drives AML with eosinophilia

一种涉及ETV6::IL3的新型三向易位驱动嗜酸性粒细胞增多症的急性髓系白血病。

Siegel, Ariel; Tripodi, Joseph; Hardatt, Dianna; Kelly, Brianna; El Ghaity-Beckley, Sebastian; Becker, Michelle; Francisco, Brenton; Bailey, Kayleen; Petersen, Bruce; Tremblay, Douglas; Feld, Jonathan; Levavi, Hannah; Kremyanskaya, Marina; Keyzner, Alla; Marcellino, Bridget K; Salib, Christian; Duffield, Amy S; Mascarenhas, John; Najfeld, Vesna; Shih, Alan H

CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells.

在原代造血干细胞中进行的 CRISPR 依赖性筛选发现 KDM3B 是 IDH2 和 TET2 突变细胞中的基因型特异性脆弱性

Waarts Michael R, Mowla Shoron, Boileau Meaghan, Martinez Benitez Anthony R, Sango Junya, Bagish Maya, Fernández-Maestre Inés, Shan Yufan, Eisman Shira E, Park Young C, Wereski Matthew, Csete Isabelle, O'Connor Kavi, Romero-Vega Angelica C, Miles Linde A, Xiao Wenbin, Wu Xiaodi, Koche Richard P, Armstrong Scott A, Shih Alan H, Papapetrou Eirini P, Butler Jason M, Cai Sheng F, Bowman Robert L, Levine Ross L

Discontinuation Syndrome With JAK2 Selective Agents: Case Presentation and Mechanistic Insights

JAK2选择性药物停药综合征:病例报告及机制探讨

Handa, Shivani; Farina, Kyle A; Becker, Michelle; Kelly, Brianna; Yu, Ashley; Feld, Jonathan; Tremblay, Douglas; Marcellino, Bridget K; Salib, Christian; Mascarenhas, John; Shih, Alan H

Safety and Efficacy: Clinical Experience of Venetoclax in Combination With Hypomethylating Agents in Both Newly Diagnosed and Relapsed/Refractory Advanced Myeloid Malignancies

安全性和有效性:维奈托克联合去甲基化药物治疗新诊断和复发/难治性晚期髓系恶性肿瘤的临床经验

Feld, Jonathan; Tremblay, Douglas; Dougherty, Mikaela; Czaplinska, Tina; Sanchez, Gillian; Brady, Claudia; Kremyanskaya, Marina; Bar-Natan, Michal; Keyzner, Alla; Marcellino, Bridget K; Gabrilove, Janice; Navada, Shyamala C; Silverman, Lewis R; El Jamal, Siraj M; Mascarenhas, John; Shih, Alan H

Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML

体细胞突变驱动急性髓系白血病中特定的、但可逆的表观遗传异质性状态。

Li, Sheng; Chen, Xiaowen; Wang, Jiahui; Meydan, Cem; Glass, Jacob L; Shih, Alan H; Delwel, Ruud; Levine, Ross L; Mason, Christopher E; Melnick, Ari M

Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition

异构体转换作为获得对突变型异柠檬酸脱氢酶抑制剂耐药性的机制

Harding, James J; Lowery, Maeve A; Shih, Alan H; Schvartzman, Juan M; Hou, Shengqi; Famulare, Christopher; Patel, Minal; Roshal, Mikhail; Do, Richard K; Zehir, Ahmet; You, Daoqi; Selcuklu, S Duygu; Viale, Agnes; Tallman, Martin S; Hyman, David M; Reznik, Ed; Finley, Lydia W S; Papaemmanuil, Elli; Tosolini, Alessandra; Frattini, Mark G; MacBeth, Kyle J; Liu, Guowen; Fan, Bin; Choe, Sung; Wu, Bin; Janjigian, Yelena Y; Mellinghoff, Ingo K; Diaz, Luis A; Levine, Ross L; Abou-Alfa, Ghassan K; Stein, Eytan M; Intlekofer, Andrew M

JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition

JAK2/IDH突变驱动的骨髓增生性肿瘤对联合靶向抑制疗法敏感

McKenney, Anna Sophia; Lau, Allison N; Somasundara, Amritha Varshini Hanasoge; Spitzer, Barbara; Intlekofer, Andrew M; Ahn, Jihae; Shank, Kaitlyn; Rapaport, Franck T; Patel, Minal A; Papalexi, Efthymia; Shih, Alan H; Chiu, April; Freinkman, Elizaveta; Akbay, Esra A; Steadman, Mya; Nagaraja, Raj; Yen, Katharine; Teruya-Feldstein, Julie; Wong, Kwok-Kin; Rampal, Raajit; Vander Heiden, Matthew G; Thompson, Craig B; Levine, Ross L

Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia.

联合靶向治疗可破坏 IDH2 和 TET2 突变型急性髓系白血病中的异常致癌信号传导并逆转表观遗传功能障碍

Shih Alan H, Meydan Cem, Shank Kaitlyn, Garrett-Bakelman Francine E, Ward Patrick S, Intlekofer Andrew M, Nazir Abbas, Stein Eytan M, Knapp Kristina, Glass Jacob, Travins Jeremy, Straley Kim, Gliser Camelia, Mason Christopher E, Yen Katharine, Thompson Craig B, Melnick Ari, Levine Ross L

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations

一种用于稀有细胞群全基因组5hmC分析的高灵敏度和稳健性方法

Han, Dali; Lu, Xingyu; Shih, Alan H; Nie, Ji; You, Qiancheng; Xu, Meng Michelle; Melnick, Ari M; Levine, Ross L; He, Chuan