日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and dynamic pharmacology of μ-opioid receptor positive allosteric modulators

μ-阿片受体正向变构调节剂的发现和动态药理学

O'Brien, Evan S; Wang, Junzheng; Tanguturi, Parthasaradhireddy; Li, Mengchu; White, Elizabeth; Shiimura, Yuki; Paul, Barnali; Appourchaux, Kevin; Kumar, Kaavya Krishna; Huang, Weijiao; Majumdar, Susruta; Traynor, John R; Streicher, John M; Chen, Chunlai; Kobilka, Brian K

A cryptic pocket in CB1 drives peripheral and functional selectivity

CB1 中的一个隐蔽口袋驱动外周和功能选择性

Rangari, Vipin Ashok; O'Brien, Evan S; Powers, Alexander S; Slivicki, Richard A; Bertels, Zachariah; Appourchaux, Kevin; Aydin, Deniz; Ramos-Gonzalez, Nokomis; Mwirigi, Juliet; Lin, Li; Mangutov, Elizaveta; Sobecks, Briana L; Awad-Agbaria, Yaseen; Uphade, Manoj B; Aguilar, Jhoan; Peddada, Teja Nikhil; Shiimura, Yuki; Huang, Xi-Ping; Folarin-Hines, Jakayla; Payne, Maria; Kalathil, Anirudh; Varga, Balazs R; Kobilka, Brian K; Pradhan, Amynah A; Cameron, Michael D; Kumar, Kaavya Krishna; Dror, Ron O; Gereau, Robert W 4th; Majumdar, Susruta

Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects.

针对副作用较小的 1 型大麻素受体激动剂的虚拟库对接

Tummino Tia A, Iliopoulos-Tsoutsouvas Christos, Braz Joao M, O'Brien Evan S, Stein Reed M, Craik Veronica, Tran Ngan K, Ganapathy Suthakar, Liu Fangyu, Shiimura Yuki, Tong Fei, Ho Thanh C, Radchenko Dmytro S, Moroz Yurii S, Rosado Sian Rodriguez, Bhardwaj Karnika, Benitez Jorge, Liu Yongfeng, Kandasamy Herthana, Normand Claire, Semache Meriem, Sabbagh Laurent, Glenn Isabella, Irwin John J, Kumar Kaavya Krishna, Makriyannis Alexandros, Basbaum Allan I, Shoichet Brian K

How the ghrelin receptor recognizes the acyl-modified orexigenic hormone

胃饥饿素受体如何识别酰基修饰的促食欲激素

Shiimura, Yuki; Kojima, Masayasu; Sato, Takahiro

Ghrelin-LEAP2 interactions along the stomach-liver axis

胃-肝轴上的生长素释放肽-LEAP2相互作用

Sakai, Katsuya; Nakazato, Yuki; Shiimura, Yuki; Zhang, Weidong; Nakazato, Masamitsu

A µ-opioid receptor modulator that works cooperatively with naloxone.

一种与纳洛酮协同作用的μ-阿片受体调节剂

O'Brien Evan S, Rangari Vipin Ashok, El Daibani Amal, Eans Shainnel O, Hammond Haylee R, White Elizabeth, Wang Haoqing, Shiimura Yuki, Krishna Kumar Kaavya, Jiang Qianru, Appourchaux Kevin, Huang Weijiao, Zhang Chensong, Kennedy Brandon J, Mathiesen Jesper M, Che Tao, McLaughlin Jay P, Majumdar Susruta, Kobilka Brian K

Neurotransmitter recognition by human vesicular monoamine transporter 2

人类囊泡单胺转运体 2 识别神经递质

Dohyun Im #, Mika Jormakka #, Narinobu Juge #, Jun-Ichi Kishikawa, Takayuki Kato, Yukihiko Sugita, Takeshi Noda, Tomoko Uemura, Yuki Shiimura, Takaaki Miyaji, Hidetsugu Asada, So Iwata3

Acyl modifications in bovine, porcine, and equine ghrelins

牛、猪和马生长素释放肽的酰基修饰

Ida, Takanori; Tominaga, Hatsumi; Iwamoto, Eri; Kurogi, Akito; Okura, Ayaka; Shimada, Kengo; Kato, Johji; Kuwano, Atsutoshi; Ode, Hirotaka; Nagata, Sayaka; Kitamura, Kazuo; Yazawa, Takashi; Sato-Hashimoto, Miho; Yasuda, Masahiro; Miyazato, Mikiya; Shiimura, Yuki; Sato, Takahiro; Kojima, Masayasu

Insights Into the Regulation of Offspring Growth by Maternally Derived Ghrelin

母源性生长素释放肽对后代生长调控的深入研究

Sato, Takahiro; Ida, Takanori; Shiimura, Yuki; Matsui, Kazuma; Oishi, Kanae; Kojima, Masayasu

Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias

内源性激动剂结合的 S1PR3 结构揭示了 G 蛋白亚型偏向的决定因素

Shintaro Maeda, Yuki Shiimura, Hidetsugu Asada, Kunio Hirata, Fangjia Luo, Eriko Nango, Nobuo Tanaka, Masayasu Toyomoto, Asuka Inoue, Junken Aoki, So Iwata, Masatoshi Hagiwara