日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Broad repression of DNA repair genes in senescent cells identified by integration of transcriptomic data

通过整合转录组数据,发现衰老细胞中DNA修复基因普遍受到抑制。

Frey, Yann; Haj, Majd; Ziv, Yael; Elkon, Ran; Shiloh, Yosef

ZC3H4 safeguards genome integrity by preventing transcription-replication conflicts at noncoding RNA loci.

ZC3H4 通过防止非编码 RNA 位点的转录-复制冲突来保护基因组完整性

Frey Yann, Goehring Liana, Haj Majd, Rona Gergely, Fijen Carel, Pagano Michele, Huang Tony T, Rothenberg Eli, Ziv Yael, Shiloh Yosef

The cGAS-STING, p38 MAPK, and p53 pathways link genome instability to accelerated cellular senescence in ATM-deficient murine lung fibroblasts

cGAS-STING、p38 MAPK 和 p53 通路将基因组不稳定性与 ATM 缺陷小鼠肺成纤维细胞的加速衰老联系起来。

Haj, Majd; Frey, Yann; Levon, Amit; Maliah, Avishai; Ben-Yishay, Tal; Slutsky, Rachel; Smoom, Riham; Tzfati, Yehuda; Ben-David, Uri; Levy, Carmit; Elkon, Ran; Ziv, Yael; Shiloh, Yosef

Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse.

癌细胞再上皮化增加自噬和DNA损伤:对乳腺癌休眠和复发的影响

Drago-Garcia Diana, Giri Suvendu, Chatterjee Rishita, Simoni-Nieves Arturo, Abedrabbo Maha, Genna Alessandro, Rios Mary Luz Uribe, Lindzen Moshit, Sekar Arunachalam, Gupta Nitin, Aharoni Noa, Bhandari Tithi, Mayalagu Agalyan, Schwarzmüller Luisa, Tarade Nooraldeen, Zhu Rong, Mohan-Raju Harsha-Raj, Karatekin Feride, Roncato Francesco, Eyal-Lubling Yaniv, Keidar Tal, Nof Yam, Belugali Nataraj Nishanth, Bernshtein Karin Shira, Wagner Bettina, Nair Nishanth Ulhas, Sanghvi Neel, Alon Ronen, Seger Rony, Pikarsky Eli, Donzelli Sara, Blandino Giovanni, Wiemann Stefan, Lev Sima, Prywes Ron, Barkan Dalit, Rueda Oscar M, Caldas Carlos, Ruppin Eytan, Shiloh Yosef, Dahlhoff Maik, Yarden Yosef

Accelerated replicative senescence of ataxia-telangiectasia skin fibroblasts is retained at physiologic oxygen levels, with unique and common transcriptional patterns

共济失调毛细血管扩张症皮肤成纤维细胞的加速复制性衰老在生理氧水平下仍然存在,并具有独特和共同的转录模式。

Haj, Majd; Levon, Amit; Frey, Yann; Hourvitz, Noa; Campisi, Judith; Tzfati, Yehuda; Elkon, Ran; Ziv, Yael; Shiloh, Yosef

UBQLN4 promotes STING proteasomal degradation during cisplatin-induced DNA damage in triple-negative breast cancer

UBQLN4促进顺铂诱导的三阴性乳腺癌DNA损伤过程中STING蛋白酶体的降解

Shoji, Yoshiaki; Yokoe, Takamichi; Kobayashi, Yuta; Murakami, Tomohiro; Bostick, Peter J; Shiloh, Yosef; Hoon, Dave S B; Bustos, Matias A

New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

老龄化的新特征:2022年哥本哈根老龄化会议概要

Schmauck-Medina, Tomas; Molière, Adrian; Lautrup, Sofie; Zhang, Jianying; Chlopicki, Stefan; Madsen, Helena Borland; Cao, Shuqin; Soendenbroe, Casper; Mansell, Els; Vestergaard, Mark Bitsch; Li, Zhiquan; Shiloh, Yosef; Opresko, Patricia L; Egly, Jean-Marc; Kirkwood, Thomas; Verdin, Eric; Bohr, Vilhelm A; Cox, Lynne S; Stevnsner, Tinna; Rasmussen, Lene Juel; Fang, Evandro F

It takes three to the DNA damage response tango

DNA损伤反应需要三个人才能完成。

Schlam-Babayov, Sapir; Ziv, Yael; Shiloh, Yosef

The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies

E3、E4泛素连接酶(UBE4B)在人类病理学中的作用

Antoniou, Nikolaos; Lagopati, Nefeli; Balourdas, Dimitrios Ilias; Nikolaou, Michail; Papalampros, Alexandros; Vasileiou, Panagiotis V S; Myrianthopoulos, Vassilios; Kotsinas, Athanassios; Shiloh, Yosef; Liontos, Michalis; Gorgoulis, Vassilis G

Inactive Atm abrogates DSB repair in mouse cerebellum more than does Atm loss, without causing a neurological phenotype

Atm 失活比 Atm 缺失更能抑制小鼠小脑中的 DSB 修复,且不会引起神经系统表型。

Tal, Efrat; Alfo, Marina; Zha, Shan; Barzilai, Ari; De Zeeuw, Chris I; Ziv, Yael; Shiloh, Yosef