日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Phase 1 Study of KHK4083: A Single-Blind, Randomized, Placebo-Controlled Single-Ascending-Dose Study in Healthy Adults and an Open-Label Multiple-Dose Study in Patients With Ulcerative Colitis

KHK4083 的 I 期研究:一项针对健康成年人的单盲、随机、安慰剂对照的单次递增剂量研究和一项针对溃疡性结肠炎患者的开放标签多剂量研究

Furihata, Kenichi; Ishiguro, Yoh; Yoshimura, Naoki; Ito, Hiroaki; Katsushima, Shinji; Kaneko, Etsuji; Shimabe, Munetake; Mukai, Mayumi; Watanabe, Risa; Morishige, Takuya

Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity

Evi1 对造血干细胞自我更新至关重要,它的表达标志着造血细胞具有长期多谱系再生活性

Keisuke Kataoka, Tomohiko Sato, Akihide Yoshimi, Susumu Goyama, Takako Tsuruta, Hiroshi Kobayashi, Munetake Shimabe, Shunya Arai, Masahiro Nakagawa, Yoichi Imai, Keiki Kumano, Katsuyoshi Kumagai, Naoto Kubota, Takashi Kadowaki, Mineo Kurokawa

EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization

EVI-1 与组蛋白甲基转移酶 SUV39H1 和 G9a 相互作用,实现转录抑制和骨髓永生化

S Goyama, E Nitta, T Yoshino, S Kako, N Watanabe-Okochi, M Shimabe, Y Imai, K Takahashi, M Kurokawa

Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells

Evi-1 是造血干细胞和转化白血病细胞的关键调节剂

Susumu Goyama, Go Yamamoto, Munetake Shimabe, Tomohiko Sato, Motoshi Ichikawa, Seishi Ogawa, Shigeru Chiba, Mineo Kurokawa