日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Regulatory role of the N-terminal intrinsically disordered region of the DEAD-box RNA helicase DDX3X in selective RNA recognition.

DEAD-box RNA 解旋酶 DDX3X 的 N 端固有无序区在选择性 RNA 识别中的调控作用

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-62806-7
Toyama Yuki, Takeuchi Koh, Shimada Ichio
免疫/内分泌
发表日期：2025
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Multistate Structure Determination and Dynamics Analysis Reveals a Unique Ubiquitin-Recognition Mechanism in Ubiquitin C-terminal Hydrolase

多态结构测定和动力学分析揭示了泛素C端水解酶中独特的泛素识别机制

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c06502
Okada, Mayu; Tateishi, Yutaka; Nojiri, Eri; Mikawa, Tsutomu; Rajesh, Sundaresan; Ogasa, Hiroki; Ueda, Takumi; Yagi, Hiromasa; Kohno, Toshiyuki; Kigawa, Takanori; Shimada, Ichio; Güntert, Peter; Ito, Yutaka; Ikeya, Teppei
发表日期：2025
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Structural basis of the residence time of adenosine A(2A) receptor ligands revealed by NMR

核磁共振揭示腺苷A(2A)受体配体停留时间的结构基础

期刊:Chemical Science
影响因子:7.4
doi:10.1039/d5sc02398j
Ueda, Takumi; Tsuchida, Tomoki; Kurita, Masatoshi; Mizumura, Takuya; Imai, Shunsuke; Shiraishi, Yutaro; Kofuku, Yutaka; Miyakawa, Shuhei; Fukuzawa, Kaori; Takeuchi, Koh; Shimada, Ichio
信号转导
发表日期：2025
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Two-step target recognition for the competitive inhibition activity of an anti-VEGF aptamer

抗 VEGF 适体竞争性抑制活性的两步靶标识别

期刊:RNA
影响因子:5
doi:10.1261/rna.080524.125
Takeuchi, Koh; Ueda, Takumi; Imai, Misaki; Fujisaki, Miwa; Tsujimura, Masanari; Tokunaga, Yuji; Kofuku, Yutaka; Shimada, Ichio
EGF
VEGF
发表日期：2025
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Evaluation of Drug Responses to Human β(2)AR Using Native Mass Spectrometry

利用天然质谱法评价药物对人β(2)肾上腺素能受体的反应

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.3c02737
Tajiri, Michiko; Imai, Shunsuke; Konuma, Tsuyoshi; Shimamoto, Keiko; Shimada, Ichio; Akashi, Satoko
信号转导
免疫/内分泌
Human
发表日期：2023
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Real-time monitoring of the reaction of KRAS G12C mutant specific covalent inhibitor by in vitro and in-cell NMR spectroscopy

利用体外和细胞内核磁共振波谱法实时监测KRAS G12C突变体特异性共价抑制剂的反应

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-023-46623-w
Zhao, Qingci; Haga, Ryoka; Tamura, Satoko; Shimada, Ichio; Nishida, Noritaka
细胞生物学
RAS
发表日期：2023
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Activation mechanism of the μ-opioid receptor by an allosteric modulator

变构调节剂激活μ-阿片受体的机制

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2121918119
Kaneko, Shun; Imai, Shunsuke; Asao, Nobuaki; Kofuku, Yutaka; Ueda, Takumi; Shimada, Ichio
信号转导
发表日期：2022
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Function-Related Dynamics in Multi-Spanning Helical Membrane Proteins Revealed by Solution NMR

溶液核磁共振揭示多跨膜螺旋膜蛋白的功能相关动力学

期刊:Membranes
影响因子:3.6
doi:10.3390/membranes11080604
Takeuchi, Koh; Kofuku, Yutaka; Imai, Shunsuke; Ueda, Takumi; Tokunaga, Yuji; Toyama, Yuki; Shiraishi, Yutaro; Shimada, Ichio
发表日期：2021
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Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

通过功能表征推断门控修饰毒素APETx1抑制hERG的机制

期刊:BMC Molecular and Cell Biology
影响因子:2.7
doi:10.1186/s12860-020-00337-3
Matsumura, Kazuki; Shimomura, Takushi; Kubo, Yoshihiro; Oka, Takayuki; Kobayashi, Naohiro; Imai, Shunsuke; Yanase, Naomi; Akimoto, Madoka; Fukuda, Masahiro; Yokogawa, Mariko; Ikeda, Kazuyoshi; Kurita, Jun-Ichi; Nishimura, Yoshifumi; Shimada, Ichio; Osawa, Masanori
ERG
发表日期：2021
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Conformational equilibrium shift underlies altered K(+) channel gating as revealed by NMR

核磁共振研究表明，构象平衡的改变是钾离子通道门控机制改变的根本原因。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-020-19005-3
Iwahashi, Yuta; Toyama, Yuki; Imai, Shunsuke; Itoh, Hiroaki; Osawa, Masanori; Inoue, Masayuki; Shimada, Ichio
发表日期：2020
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