日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget

有前景的基于他克林/石杉碱甲的二聚体乙酰胆碱酯酶抑制剂可用于治疗神经退行性疾病：从缓解症状到通过多靶点调控疾病进程

期刊:Journal of Neurochemistry
影响因子:4
doi:10.1111/jnc.15379
Mak, Shinghung; Li, Wenming; Fu, Hongjun; Luo, Jialie; Cui, Wei; Hu, Shengquan; Pang, Yuanping; Carlier, Paul R; Tsim, Karl Wahkeung; Pi, Rongbiao; Han, Yifan
信号转导
神经科学
发表日期：2021
文献求助 收藏

Interacting with α 7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages

与α7nAChR相互作用是AChE增强巨噬细胞炎症反应的新机制

期刊:Acta Pharmaceutica Sinica B
影响因子:14.7
doi:10.1016/j.apsb.2020.05.005
Etta Y L Liu, Yingjie Xia, Xiangpeng Kong, Maggie S S Guo, Anna X D Yu, Brody Z Y Zheng, Shinghung Mak, Miranda L Xu, Karl W K Tsim
细胞生物学
巨噬细胞
发表日期：2020
文献求助 收藏

The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models

双重功能硝酸美金刚MN-08缓解实验性蛛网膜下腔出血模型中的脑血管痉挛和脑损伤

期刊:British Journal of Pharmacology
影响因子:6.8
doi:10.1111/bph.14763
Fangcheng Luo, Liangmiao Wu, Zhixiang Zhang, Zeyu Zhu, Zheng Liu, Baojian Guo, Ning Li, Jun Ju, Qiang Zhou, Shupeng Li, Xifei Yang, Shinghung Mak, Yifan Han, Yewei Sun, Yuqiang Wang, Gaoxiao Zhang, Zaijun Zhang
信号转导
发表日期：2019
文献求助 收藏

A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

一种新型四甲基吡嗪衍生物通过阻断N-甲基-D-天冬氨酸受体，预防性地保护原代神经元免受谷氨酸诱导的兴奋性毒性损伤。

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2018.00073
Hu, Shengquan; Hu, Huihui; Mak, Shinghung; Cui, Guozhen; Lee, Mingyuen; Shan, Luchen; Wang, Yuqiang; Lin, Huangquan; Zhang, Zaijun; Han, Yifan
信号转导
毒理研究
神经科学
发表日期：2018
文献求助 收藏

Neuroprotection Against MPP+-Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3β/MEF2D Signaling Pathway by Rhynchophylline, the Major Tetracyclic Oxindole Alkaloid Isolated From Uncaria rhynchophylla

钩藤碱是从钩藤中分离的主要四环羟吲哚生物碱，通过激活 PI3-K/Akt/GSK3β/MEF2D 信号通路对 MPP+ 诱导的细胞毒性进行神经保护

期刊:Frontiers in Pharmacology
影响因子:4.4
doi:10.3389/fphar.2018.00768
Shengquan Hu, Shinghung Mak, Xialin Zuo, Haitao Li, Yuqiang Wang, Yifan Han
信号转导
神经
其它细胞
FCM
IF
IHC-P
Neuroscience
PI3K/Akt
BCL2
发表日期：2018
文献求助 收藏

Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice

他克林（10）-石芎酮通过激活 BDNF 通路和抑制 AChE 预防老年小鼠术后认知功能障碍

期刊:Frontiers in Cellular Neuroscience
影响因子:4.2
doi:10.3389/fncel.2018.00396
Huixin Chen, Xiang Wu, Xinmei Gu, Yiying Zhou, Luying Ye, Ke Zhang, Hanbo Pan, Jialing Wang, Hua Wei, Binbin Zhu, C Benjamin Naman, Shinghung Mak, Paul R Carlier, Wei Cui, Yifan Han
信号转导
发表日期：2018
文献求助 收藏

Indirubin-3-Oxime Prevents H(2)O(2)-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway

靛玉红-3-肟通过同时抑制GSK3β和ERK通路来阻止H(2)O(2)诱导的神经元凋亡

期刊:Cellular and Molecular Neurobiology
影响因子:4.8
doi:10.1007/s10571-016-0402-z
Yu, Jie; Zheng, Jiacheng; Lin, Jiajia; Jin, Linlu; Yu, Rui; Mak, Shinghung; Hu, Shengquan; Sun, Hongya; Wu, Xiang; Zhang, Zaijun; Lee, Mingyuen; Tsim, Wahkeung; Su, Wei; Zhou, Wenhua; Cui, Wei; Han, Yifan; Wang, Qinwen
凋亡
表观遗传
Apoptosis
信号转导
神经科学
MAPK/ERK
GSK3
发表日期：2017
文献求助 收藏

Assessment of Neuronal Viability Using Fluorescein Diacetate-Propidium Iodide Double Staining in Cerebellar Granule Neuron Culture

利用荧光素二乙酸酯-碘化丙啶双重染色法评估小脑颗粒神经元培养物中的神经元活力

期刊:Jove-Journal of Visualized Experiments
影响因子:1
doi:10.3791/55442
Jiajia, Lin; Shinghung, Mak; Jiacheng, Zheng; Jialing, Wang; Dilin, Xu; Shengquan, Hu; Zaijun, Zhang; Qinwen, Wang; Yifan, Han; Wei, Cui
IF
神经科学
发表日期：2017
文献求助 收藏

Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin

通过双（庚基）-认知素改变 β-淀粉样蛋白的组装来预防 β-淀粉样蛋白引起的突触和记忆障碍

期刊:Scientific Reports
影响因子:3.8
doi:10.1038/srep10256
Lan Chang, Wei Cui, Yong Yang, Shujun Xu, Wenhua Zhou, Hongjun Fu, Shengquan Hu, Shinghung Mak, Juwei Hu, Qin Wang, Victor Pui-Yan Ma, Tony Chung-lit Choi, Edmond Dik-lung Ma, Liang Tao, Yuanping Pang, Michael J Rowan, Roger Anwyl, Yifan Han, Qinwen Wang
信号转导
发表日期：2015
文献求助 收藏