日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

EGFL6 promotes colorectal cancer cell growth and mobility and the anti-cancer property of anti-EGFL6 antibody

EGFL6促进结直肠癌细胞生长和迁移以及抗EGFL6抗体的抗癌特性

期刊:Cell and Bioscience
影响因子:6.1
doi:10.1186/s13578-021-00561-0
Ting-Yi Sung #, Han-Li Huang #, Chun-Chun Cheng, Fu-Ling Chang, Po-Li Wei, Ya-Wen Cheng, Cheng-Chiao Huang, Yu-Ching Lee, Wei-Chun HuangFu, Shiow-Lin Pan
肿瘤
肠癌
肿瘤细胞
发表日期：2021
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Identification and biological evaluation of benzimidazole-based compounds as novel TGFβR1 inhibitors

鉴定和生物学评价苯并咪唑类化合物作为新型TGFβR1抑制剂

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2600746
Tseng, Hui-Ju; Wu, Yi-Wen; Chen, Yan-Ling; Lin, Tony Eight; Fang-Chin, Yu-Ting; Wu, Yueh-Lin; Sung, Tzu-Ying; Yen, Shih-Chung; Hsieh, Jui-Hua; Hsu, Kai-Cheng; Pan, Shiow-Lin
TGFβ
发表日期：2026
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Consensus Pharmacological Interactions for PLK2 Inhibitor Identification in Colorectal Cancer Treatment

结直肠癌治疗中PLK2抑制剂鉴定的共识药理学相互作用

期刊:Journal of Chemical Information and Modeling
影响因子:5.3
doi:10.1021/acs.jcim.5c02197
Wu, Yi-Wen; Yang, Chun-Lin; Lin, Tony Eight; Yeh, Yun-Hsuan; Fang-Chin, Yu-Ting; Sung, Tzu-Ying; Yen, Shih-Chung; Hsieh, Jui-Hua; Chung, Cheng-Chih; Pan, Shiow-Lin; Hsu, Kai-Cheng
肿瘤
肠癌
肿瘤免疫
发表日期：2026
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Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure-Based Virtual Screening.

利用基于结构的虚拟筛选方法鉴定和生物学评价一种靶向胰腺癌中选择性剪接的新型 CLK4 抑制剂

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202416323
Yang Chun-Lin, Wu Yi-Wen, Tu Huang-Ju, Yeh Yun-Hsuan, Lin Tony Eight, Sung Tzu-Ying, Li Mu-Chun, Yen Shih-Chung, Hsieh Jui-Hua, Yu Ming-Chin, Hsieh Sen-Yung, Hsieh Hsing-Pang, Pan Shiow-Lin, Hsu Kai-Cheng
肿瘤
胰腺癌
发表日期：2025
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Discovery of a novel RSK2 inhibitor for the treatment of metastatic pancreatic cancer

发现一种新型RSK2抑制剂可用于治疗转移性胰腺癌

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.6
doi:10.1080/14756366.2025.2538673
Chi-Hsiu Chung,Kai-Cheng Hsu,Ming-Min Huang,Huang-Ju Tu,Shiow-Lin Pan,Min-Wu Chao
胰腺癌
肿瘤
Rsk
发表日期：2025
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Exploring diarylheptanoid derivatives to target LIMK1 as potential agents against colorectal cancer

探索以LIMK1为靶点的二芳基庚烷衍生物作为潜在的结直肠癌治疗药物

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2583826
Chen, Liang-Chieh; Chang, Tung-Cheng; Tseng, Hui-Ju; Chu, Jung-Chun; Huang, Yun-Yi; Peng, Hao-Yuan; Kuo, Yi-Chen; Wu, Yi-Wen; Lin, Tony Eight; Yen, Shih-Chung; Hsu, Kai-Cheng; Huang, Wei-Jan; Pan, Shiow-Lin
肿瘤
肠癌
肿瘤免疫
LIMK1
发表日期：2025
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Identification of a Potent CDK8 Inhibitor Using Structure-Based Virtual Screening

利用基于结构的虚拟筛选鉴定高效 CDK8 抑制剂

期刊:Journal of Chemical Information and Modeling
影响因子:5.3
doi:10.1021/acs.jcim.4c02011
Lin, Tony Eight; Chou, Ching-Hsuan; Wu, Yi-Wen; Sung, Tzu-Ying; Hsu, Jui-Yi; Yen, Shih-Chung; Hsieh, Jui-Hua; Chang, Yu-Wei; Pan, Shiow-Lin; Huang, Wei-Jan; Hsu, Kai-Cheng; Yang, Chia-Ron
CDK8
发表日期：2025
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Syntheses of LSD1/HDAC Inhibitors with Demonstrated Efficacy against Colorectal Cancer: In Vitro and In Vivo Studies Including Patient-Derived Organoids

已证实对结直肠癌有效的 LSD1/HDAC 抑制剂的合成：包括患者来源的类器官在内的体外和体内研究

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c01098
Po-Yu Chou, Mei-Jung Lai, Kelvin K Tsai, Li-Hsin Cheng, Yi-Wen Wu, Mei-Chuan Chen, Shiow-Lin Pan, Hsiu-O Ho, Kunal Nepali, Jing-Ping Liou
肿瘤
肠癌
发表日期：2024
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Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation

发现一种新型双特异性酪氨酸磷酸化调节激酶1A (DYRK1A) 抑制剂及其对tau蛋白磷酸化和β-淀粉样蛋白形成的影响

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.6
doi:10.1080/14756366.2024.2418470
Huang-Ju Tu ，Min-Wu Chao ，Cheng-Chung Lee ，Chao-Shiang Peng ，Yi-Wen Wu ，Tony Eight Lin ，Yu-Wei Chang ，Shih-Chung Yen ，Kai-Cheng Hsu ，Shiow-Lin Pan ，Wei-Chun HuangFu
DYR
磷酸化
DYRK1A
信号转导
发表日期：2024
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An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors

集成机器学习模型生成一个针对性筛选库，用于识别 CDK8 抑制剂。

期刊:Protein Science
影响因子:5.2
doi:10.1002/pro.5007
Lin, Tony Eight; Yen, Dyan; HuangFu, Wei-Chun; Wu, Yi-Wen; Hsu, Jui-Yi; Yen, Shih-Chung; Sung, Tzu-Ying; Hsieh, Jui-Hua; Pan, Shiow-Lin; Yang, Chia-Ron; Huang, Wei-Jan; Hsu, Kai-Cheng
CDK8
发表日期：2024
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