Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors
发现新型3,3-二取代哌啶类化合物作为口服生物利用度高、效力强、疗效显著的HDM2-p53抑制剂
期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.5b00472
Bogen, Stéphane L; Pan, Weidong; Gibeau, Craig R; Lahue, Brian R; Ma, Yao; Nair, Latha G; Seigel, Elise; Shipps, Gerald W Jr; Tian, Yuan; Wang, Yaolin; Lin, Yinghui; Liu, Ming; Liu, Suxing; Mirza, Asra; Wang, Xiaoying; Lipari, Philip; Seidel-Dugan, Cynthia; Hicklin, Daniel J; Bishop, W Robert; Rindgen, Diane; Nomeir, Amin; Prosise, Winifred; Reichert, Paul; Scapin, Giovanna; Strickland, Corey; Doll, Ronald J