日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer

突变型p53结合并控制雌激素受体活性,从而驱动卵巢癌的内分泌耐药性。

Shao, Chunlei; Indeglia, Alexandra; Foster, Maya; Casey, Kaitlyn; Leung, Jessica; Modarai, Shirin R; Leu, Julia I-Ju; Duong, Bryant; Mes-Masson, Anne-Marie; Sims-Mourtada, Jennifer; Auslander, Noam; Drapkin, Ronny; Bitler, Benjamin G; Zhang, Nan; Murphy, Maureen E

B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer

细胞增强 IL-1β 驱动的三阴性乳腺癌侵袭性

Nicole J Toney, Lynn M Opdenaker, Lisa Frerichs, Shirin R Modarai, Aihui Ma, Holly Archinal, Grace O Ajayi, Jennifer Sims-Mourtada

Dynamic Organization of Cells in Colonic Epithelium is Encoded by Five Biological Rules

结肠上皮细胞的动态组织由五条生物学规则编码

Boman, Bruce M; Dinh, Thien-Nam; Decker, Keith; Emerick, Brooks; Modarai, Shirin R; Opdenaker, Lynn M; Fields, Jeremy Z; Raymond, Christopher; Schleiniger, Gilberto

B cells enhance IL-1 beta driven invasiveness in triple-negative breast cancer

细胞增强 IL-1β 驱动的三阴性乳腺癌侵袭性

Nicole J Toney, Lynn M Opdenaker, Lisa Frerichs, Shirin R Modarai, Aihui Ma, Holly Archinal, Grace O Ajayi, Jennifer Sims-Mourtada

Precise and error-prone CRISPR-directed gene editing activity in human CD34+ cells varies widely among patient samples

人类 CD34+ 细胞中 CRISPR 定向基因编辑的精确度和易错性在不同患者样本中存在很大差异

Shirin R Modarai, Sambee Kanda, Kevin Bloh, Lynn M Opdenaker, Eric B Kmiec

APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development

人类结肠中的 APC 突变导致 ALDH+ 干细胞神经内分泌成熟度降低,从而改变 GLP-2 和 SST 反馈信号:WNT 与视黄酸信号在结肠癌发展中存在联系的线索

Tao Zhang, Koree Ahn, Brooks Emerick, Shirin R Modarai, Lynn M Opdenaker, Juan Palazzo, Gilberto Schleiniger, Jeremy Z Fields, Bruce M Boman

Efficient Delivery and Nuclear Uptake Is Not Sufficient to Detect Gene Editing in CD34+ Cells Directed by a Ribonucleoprotein Complex

有效的递送和核摄取不足以检测由核糖核蛋白复合物指导的 CD34+ 细胞中的基因编辑

Shirin R Modarai, Dula Man, Pawel Bialk, Natalia Rivera-Torres, Kevin Bloh, Eric B Kmiec

Increased Musashi-2 and Decreased NUMB Protein Levels Observed in Human Colorectal Cancer are reverted to Normal Levels by ATRA-Induced Cell Differentiation

在人类结直肠癌中观察到的 Musashi-2 蛋白水平升高和 NUMB 蛋白水平降低可通过 ATRA 诱导的细胞分化恢复至正常水平。

Opdenaker, Lynn M; Kowash, Ryan; Masters, Gabriel; Boman, Bruce M; Zhang, Tao; Modarai, Shirin R

The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells

视黄酸信号在 CRC 中的抗癌作用是通过降低 ALDH+ 结肠癌干细胞的生长和增加干细胞的分化来实现的

Shirin R Modarai, Anindita Gupta, Lynn M Opdenaker, Ryan Kowash, Gabriel Masters, Vignesh Viswanathan, Tao Zhang, Jeremy Z Fields, Bruce M Boman

Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells

生长抑素通过 SSTR1 发出信号,导致结肠癌干细胞处于静止状态

Shirin R Modarai, Lynn M Opdenaker, Vignesh Viswanathan, Jeremy Z Fields, Bruce M Boman