Shirin R Modarai相关文献与解析，生知库 | 链接生命科学的每一步

Precise and error-prone CRISPR-directed gene editing activity in human CD34+ cells varies widely among patient samples

人类 CD34+ 细胞中 CRISPR 定向基因编辑的精确度和易错性在不同患者样本中存在很大差异

期刊:Gene Therapy

影响因子:4.6

doi:10.1038/s41434-020-00192-z

Shirin R Modarai, Sambee Kanda, Kevin Bloh, Lynn M Opdenaker, Eric B Kmiec

APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development

人类结肠中的 APC 突变导致 ALDH+ 干细胞神经内分泌成熟度降低，从而改变 GLP-2 和 SST 反馈信号：WNT 与视黄酸信号在结肠癌发展中存在联系的线索

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0239601

Tao Zhang, Koree Ahn, Brooks Emerick, Shirin R Modarai, Lynn M Opdenaker, Juan Palazzo, Gilberto Schleiniger, Jeremy Z Fields, Bruce M Boman

Efficient Delivery and Nuclear Uptake Is Not Sufficient to Detect Gene Editing in CD34+ Cells Directed by a Ribonucleoprotein Complex

有效的递送和核摄取不足以检测由核糖核蛋白复合物指导的 CD34+ 细胞中的基因编辑

期刊:Molecular Therapy-Nucleic Acids

影响因子:6.5

doi:10.1016/j.omtn.2018.01.013

Shirin R Modarai, Dula Man, Pawel Bialk, Natalia Rivera-Torres, Kevin Bloh, Eric B Kmiec

The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells

视黄酸信号在 CRC 中的抗癌作用是通过降低 ALDH+ 结肠癌干细胞的生长和增加干细胞的分化来实现的

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.26157

Shirin R Modarai, Anindita Gupta, Lynn M Opdenaker, Ryan Kowash, Gabriel Masters, Vignesh Viswanathan, Tao Zhang, Jeremy Z Fields, Bruce M Boman

Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells

生长抑素通过 SSTR1 发出信号，导致结肠癌干细胞处于静止状态

期刊:BMC Cancer

影响因子:3.4

doi:10.1186/s12885-016-2969-7

Shirin R Modarai, Lynn M Opdenaker, Vignesh Viswanathan, Jeremy Z Fields, Bruce M Boman

The Proportion of ALDEFLUOR-Positive Cancer Stem Cells Changes with Cell Culture Density Due to the Expression of Different ALDH Isoforms

由于 ALDH 亚型的表达不同，ALDEFLUOR 阳性癌症干细胞的比例会随着细胞培养密度的变化而变化

期刊:

影响因子:

doi:10.17140/CSMMOJ-2-113

Lynn M Opdenaker, Shirin R Modarai, Bruce M Boman

B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer

细胞增强 IL-1β 驱动的三阴性乳腺癌侵袭性

B cells enhance IL-1 beta driven invasiveness in triple-negative breast cancer

细胞增强 IL-1β 驱动的三阴性乳腺癌侵袭性

Precise and error-prone CRISPR-directed gene editing activity in human CD34+ cells varies widely among patient samples

人类 CD34+ 细胞中 CRISPR 定向基因编辑的精确度和易错性在不同患者样本中存在很大差异

APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development

人类结肠中的 APC 突变导致 ALDH+ 干细胞神经内分泌成熟度降低，从而改变 GLP-2 和 SST 反馈信号：WNT 与视黄酸信号在结肠癌发展中存在联系的线索

Efficient Delivery and Nuclear Uptake Is Not Sufficient to Detect Gene Editing in CD34+ Cells Directed by a Ribonucleoprotein Complex

有效的递送和核摄取不足以检测由核糖核蛋白复合物指导的 CD34+ 细胞中的基因编辑

The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells

视黄酸信号在 CRC 中的抗癌作用是通过降低 ALDH+ 结肠癌干细胞的生长和增加干细胞的分化来实现的

Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells

生长抑素通过 SSTR1 发出信号，导致结肠癌干细胞处于静止状态

The Proportion of ALDEFLUOR-Positive Cancer Stem Cells Changes with Cell Culture Density Due to the Expression of Different ALDH Isoforms

由于 ALDH 亚型的表达不同，ALDEFLUOR 阳性癌症干细胞的比例会随着细胞培养密度的变化而变化