日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Allosteric Inhibitors of Zika Virus NS2B-NS3 Protease Targeting Protease in "Super-Open" Conformation

寨卡病毒NS2B-NS3蛋白酶的变构抑制剂靶向处于“超开放”构象的蛋白酶

Meewan, Ittipat; Shiryaev, Sergey A; Kattoula, Julius; Huang, Chun-Teng; Lin, Vivian; Chuang, Chiao-Han; Terskikh, Alexey V; Abagyan, Ruben

Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming

冠状病毒刺突糖蛋白启动的潜在治疗靶点

Barile, Elisa; Baggio, Carlo; Gambini, Luca; Shiryaev, Sergey A; Strongin, Alex Y; Pellecchia, Maurizio

Predominant and novel de novo variants in 29 individuals with ALG13 deficiency: Clinical description, biomarker status, biochemical analysis, and treatment suggestions

29例ALG13缺陷患者的主要和新发变异:临床描述、生物标志物状态、生化分析和治疗建议

Ng, Bobby G; Eklund, Erik A; Shiryaev, Sergey A; Dong, Yin Y; Abbott, Mary-Alice; Asteggiano, Carla; Bamshad, Michael J; Barr, Eileen; Bernstein, Jonathan A; Chelakkadan, Shabeed; Christodoulou, John; Chung, Wendy K; Ciliberto, Michael A; Cousin, Janice; Gardiner, Fiona; Ghosh, Suman; Graf, William D; Grunewald, Stephanie; Hammond, Katherine; Hauser, Natalie S; Hoganson, George E; Houck, Kimberly M; Kohler, Jennefer N; Morava, Eva; Larson, Austin A; Liu, Pengfei; Madathil, Sujana; McCormack, Colleen; Meeks, Naomi J L; Miller, Rebecca; Monaghan, Kristin G; Nickerson, Deborah A; Palculict, Timothy Blake; Papazoglu, Gabriela Magali; Pletcher, Beth A; Scheffer, Ingrid E; Schenone, Andrea Beatriz; Schnur, Rhonda E; Si, Yue; Rowe, Leah J; Serrano Russi, Alvaro H; Russo, Rossana Sanchez; Thabet, Farouq; Tuite, Allysa; Villanueva, María Mercedes; Wang, Raymond Y; Webster, Richard I; Wilson, Dorcas; Zalan, Alice; Wolfe, Lynne A; Rosenfeld, Jill A; Rhodes, Lindsay; Freeze, Hudson H

Partial Jacobsen syndrome phenotype in a patient with a de novo frameshift mutation in the ETS1 transcription factor

一名ETS1转录因子发生新生移码突变的患者表现出部分雅各布森综合征表型

Tootleman, Eva; Malamut, Barbara; Akshoomoff, Natacha; Mattson, Sarah N; Hoffman, Hal M; Jones, Marilyn C; Printz, Beth; Shiryaev, Sergey A; Grossfeld, Paul

ALG1-CDG: Clinical and Molecular Characterization of 39 Unreported Patients

ALG1-CDG:39例未报道患者的临床和分子特征分析

Ng, Bobby G; Shiryaev, Sergey A; Rymen, Daisy; Eklund, Erik A; Raymond, Kimiyo; Kircher, Martin; Abdenur, Jose E; Alehan, Fusun; Midro, Alina T; Bamshad, Michael J; Barone, Rita; Berry, Gerard T; Brumbaugh, Jane E; Buckingham, Kati J; Clarkson, Katie; Cole, F Sessions; O'Connor, Shawn; Cooper, Gregory M; Van Coster, Rudy; Demmer, Laurie A; Diogo, Luisa; Fay, Alexander J; Ficicioglu, Can; Fiumara, Agata; Gahl, William A; Ganetzky, Rebecca; Goel, Himanshu; Harshman, Lyndsay A; He, Miao; Jaeken, Jaak; James, Philip M; Katz, Daniel; Keldermans, Liesbeth; Kibaek, Maria; Kornberg, Andrew J; Lachlan, Katherine; Lam, Christina; Yaplito-Lee, Joy; Nickerson, Deborah A; Peters, Heidi L; Race, Valerie; Régal, Luc; Rush, Jeffrey S; Rutledge, S Lane; Shendure, Jay; Souche, Erika; Sparks, Susan E; Trapane, Pamela; Sanchez-Valle, Amarilis; Vilain, Eric; Vøllo, Arve; Waechter, Charles J; Wang, Raymond Y; Wolfe, Lynne A; Wong, Derek A; Wood, Tim; Yang, Amy C; Matthijs, Gert; Freeze, Hudson H

Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury.

基质金属蛋白酶-14 既能使巨噬细胞表面的神经元胶质抗原 2 (NG2) 蛋白聚糖脱落,又能控制周围神经损伤的反应

Nishihara Tasuku, Remacle Albert G, Angert Mila, Shubayev Igor, Shiryaev Sergey A, Liu Huaqing, Dolkas Jennifer, Chernov Andrei V, Strongin Alex Y, Shubayev Veronica I

High-Throughput Multiplexed Peptide-Centric Profiling Illustrates Both Substrate Cleavage Redundancy and Specificity in the MMP Family.

高通量多重肽中心分析揭示了 MMP 家族的底物切割冗余性和特异性

Kukreja Muskan, Shiryaev Sergey A, Cieplak Piotr, Muranaka Norihito, Routenberg David A, Chernov Andrei V, Kumar Sonu, Remacle Albert G, Smith Jeffrey W, Kozlov Igor A, Strongin Alex Y

Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island

脆弱拟杆菌致病岛编码的金属蛋白酶的结构和功能多样性

Shiryaev, Sergey A; Aleshin, Alexander E; Muranaka, Norihito; Kukreja, Muskan; Routenberg, David A; Remacle, Albert G; Liddington, Robert C; Cieplak, Piotr; Kozlov, Igor A; Strongin, Alex Y

The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase

NS4A辅因子的酸性序列调节HCV NS3解旋酶的ATP水解。

Shiryaev, Sergey A; Chernov, Andrei V; Shiryaeva, Tatiana N; Aleshin, Alexander E; Strongin, Alex Y

Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase

利用美国国家癌症研究所 (NCI) 化合物库进行虚拟配体筛选,获得了西尼罗河病毒 NS3 蛋白酶的变构抑制剂骨架。

Shiryaev, Sergey A; Cheltsov, Anton V; Gawlik, Katarzyna; Ratnikov, Boris I; Strongin, Alex Y