日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Severe Consequences of SAC3/FIG4 Phosphatase Deficiency to Phosphoinositides in Patients with Charcot-Marie-Tooth Disease Type-4J

SAC3/FIG4磷酸酶缺乏对夏科-马里-图斯病4J型患者磷脂酰肌醇的严重影响

Shisheva, Assia; Sbrissa, Diego; Hu, Bo; Li, Jun

Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation

Apilimod 是一种候选抗癌疗法,它不仅能抑制 PtdIns(3,5)P2 的合成,还能抑制 PIKfyve 介导的 PtdIns5P 的合成,并诱导巴弗洛霉素 A1 可逆的异常内膜扩张。

Sbrissa, Diego; Naisan, Ghassan; Ikonomov, Ognian C; Shisheva, Assia

Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells

液泡蛋白分选的不同需求 34 足细胞与近端小管细胞中的下游效应磷脂酰肌醇 3-磷酸 5-激酶

Venkatareddy, Madhusudan; Verma, Rakesh; Kalinowski, Anne; Patel, Sanjeevkumar R; Shisheva, Assia; Garg, Puneet

Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency

PIKfyve 或 Vps34 缺陷导致的 PtdIns(3,5)P2 丢失会引发空泡化缺陷,而活性液泡 H+ ATPase 和 Rab5 的功能循环是必需的。

Compton, Lauren M; Ikonomov, Ognian C; Sbrissa, Diego; Garg, Puneet; Shisheva, Assia

GAPDH binds Akt to facilitate cargo transport in the early secretory pathway

GAPDH 与 Akt 结合,促进早期分泌途径中的货物运输。

Tisdale, Ellen J; Talati, Nikunj K; Artalejo, Cristina R; Shisheva, Assia

Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012)

丰富的 PtdIns5P 是由稀少的 PtdIns(3,5)P2 产生,还是由充足的 PtdIns 产生?PIKfyve 依赖模型:证据与推测(回应:DOI 10.1002/bies.201300012)

Shisheva, Assia; Sbrissa, Diego; Ikonomov, Ognian

Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection

宿主PI(3,5)P2活性是伯氏疟原虫肝期感染期间生长所必需的。

Thieleke-Matos, Carolina; da Silva, Mafalda Lopes; Cabrita-Santos, Laura; Pires, Cristiana F; Ramalho, José S; Ikonomov, Ognian; Seixas, Elsa; Shisheva, Assia; Seabra, Miguel C; Barral, Duarte C

The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines.

PIKfyve-ArPIKfyve-Sac3 三联体在人类乳腺癌中的作用:Sac3 磷酸酶升高与三阴性细胞系增殖增强之间的功能联系

Ikonomov Ognian C, Filios Catherine, Sbrissa Diego, Chen Xuequn, Shisheva Assia

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

利用PIKfyve抑制剂YM201636实现PIKfyve合成的PtdIns5P与PtdIns(3,5)P2之间的功能性分离

Sbrissa, Diego; Ikonomov, Ognian C; Filios, Catherine; Delvecchio, Khortnal; Shisheva, Assia

PIKfyve: Partners, significance, debates and paradoxes

PIKfyve:合作伙伴、意义、争论与悖论

Shisheva, Assia