日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators

获得的靶向改变导致对 p53-Y220C 激活剂的临床耐药性

Fece de la Cruz, Ferran; Varkaris, Andreas; Patel, Parasvi S; Kushner, Elijah W; Morales-Giron, Alvin A; Lee, Sangmi Sandra; Singh, Ankit; Kim, Clara T; Norden, Bryanna L; Ehnstrom, Sara; Riedl, Jakob M; Curtis, Jacquelyn M; Barnes, Haley; Kehlmann, Allison M; Chevalier, Nicholas J; Okuma, Hitomi S; Patel, Manisha; Wirth, Lori J; Connell, Brendan; Nugent, Francis; Pappas, Leontios; Lau, Kayao; Juric, Dejan; Hopkins, Jessica L; Guiley, Keelan Z; Shokat, Kevan M; Gulhan, Doga C; Parikh, Aparna R; Corcoran, Ryan B

The GENEVA platform models tumor mosaicism to reveal variations of responses to KRAS inhibitors and identify improved drug combinations

GENEVA平台通过模拟肿瘤嵌合现象,揭示KRAS抑制剂反应的差异,并识别更有效的药物组合。

Yu, Johnny X; Suh, Jung Min; Popova, Katerina D; Garcia, Kristle; Joshi, Tanvi; Culbertson, Bruce; Spinelli, Jessica B; Subramanyam, Vishvak; Lou, Kevin; Charbonneau, Trey; Shokat, Kevan M; Weissman, Jonathan; Goodarzi, Hani

Integrating GWAS and gene expression to decipher genetic components of pericarp thickness and soluble sugars in sweet corn

整合全基因组关联分析和基因表达分析,解析甜玉米果皮厚度和可溶性糖的遗传组成

Ashraf, Humera; Wu, Yu; Xiao, Yingni; Liang, Xinyue; Li, Xiaofeng; Shokat, Sajid; Li, Yuliang

A Dimeric Rocaglate Promotes Multivalent eIF4A-RNA Assembly.

二聚体罗卡格酸酯促进多价eIF4A-RNA组装。

Liu Jie, Moore Megan K, Lou Kevin, Wassarman Douglas R, Arab Abolfazl, Ojeda Samuel, Karakyriakou Barbara, Koglin Ann-Sophie, Ott Christopher J, Gilbert Luke A, Shokat Kevan M

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity

脱氮鸟苷酸化是核碱基与蛋白质结合所必需的IV型CBASS免疫反应。

Wassarman, Douglas R; Pfaff, Patrick; Paulo, Joao A; Gygi, Steven P; Shokat, Kevan M; Kranzusch, Philip J

Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer

基因组规模的 CRISPR 筛选发现 PTGES3 是晚期前列腺癌中雄激素受体功能的直接调节因子

Haolong Li,James E Melnyk,Becky Xu Hua Fu,Raunak Shrestha,Meng Zhang,Martin Sjöström,Siyu Feng,Jasmine A Anderson,Wanting Han,Lisa N Chesner,Hyun Jin Shin,Tatyanah Farsh,Humberto J Suarez,Seema Nath,Jonathan Chou,Rajdeep Das,Emily A Egusa,Marsha Calvert,Audrey Kishishita,Abhilash Barpanda,Jun Zhu,Ashutosh Maheshwari,William S Chen,Mohammed Alshalalfa,Aidan Winters,Junjie T Hua,Tianyi Liu,Elai Davicioni,Arun P Wiita,Bradley A Stohr,Javed Siddiqui,Bo Huang,Eric J Small,Kevan M Shokat,Peter S Nelson,David A Quigley,Elizabeth V Wasmuth,Luke A Gilbert,Felix Y Feng

HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma.

HBV通过重塑PP2A复合物来重新连接肝细胞癌中的激酶信号通路

Turnham Rigney E, Pitea Adriana, Jang Gwendolyn M, Xu Zhong, Lim Huat Chye, Choi Alex L, Von Dollen John, Levin Rebecca S, Webber James T, McCarthy Elizabeth, Hu Junjie, Li Xiaolei, Che Li, Singh Ananya, Yoon Alex, Chan Gary K L, Kelley Robin K, Swaney Danielle L, Zhang Wei, Bandyopadhyay Sourav, Theis Fabian J, Eckhardt Manon, Chen Xin, Shokat Kevan M, Ideker Trey, Krogan Nevan J, Gordan John D

Denitrogenative Alkylation of K-Ras(G12D) Inhibits Oncogenic Signaling in Cancer Cells

K-Ras(G12D)的脱氮烷基化抑制癌细胞中的致癌信号传导

Zheng, Qinheng; Shokat, Kevan M

De-ashed-biochar slow-release N fertilizer increased NUE in alkaline calcareous soils under wheat and maize crops

脱灰生物炭缓释氮肥提高了小麦和玉米在碱性钙质土壤中的氮肥利用率。

Rashid, Muhammad; Hussain, Qaiser; Khan, Khalid Saifullah; Alvi, Sarosh; Abro, Shokat Ali; Akmal, Muhammad; Ijaz, Shahzada Sohail; Umer, Muhammad; Qureshi, Abdul Ahad; Elshikh, Mohamed S; Rizwana, Humaira; Rizwan, Muhammad; Iqbal, Rashid

Reactive oxygen species production and signal transduction in response to stress triggered by Alternaria elicitors in Brassicaceae

十字花科植物中由链格孢菌诱导子引发的胁迫反应中活性氧的产生和信号转导

Munir, Sana; Shahzad, Ahmad N; Rai, Avanish; Petrov, Veselin; Gechev, Tsanko; Shokat, Sajid; Qureshi, Muhammad K