日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators

获得的靶向改变导致对 p53-Y220C 激活剂的临床耐药性

Fece de la Cruz, Ferran; Varkaris, Andreas; Patel, Parasvi S; Kushner, Elijah W; Morales-Giron, Alvin A; Lee, Sangmi Sandra; Singh, Ankit; Kim, Clara T; Norden, Bryanna L; Ehnstrom, Sara; Riedl, Jakob M; Curtis, Jacquelyn M; Barnes, Haley; Kehlmann, Allison M; Chevalier, Nicholas J; Okuma, Hitomi S; Patel, Manisha; Wirth, Lori J; Connell, Brendan; Nugent, Francis; Pappas, Leontios; Lau, Kayao; Juric, Dejan; Hopkins, Jessica L; Guiley, Keelan Z; Shokat, Kevan M; Gulhan, Doga C; Parikh, Aparna R; Corcoran, Ryan B

The GENEVA platform models tumor mosaicism to reveal variations of responses to KRAS inhibitors and identify improved drug combinations

GENEVA平台通过模拟肿瘤嵌合现象,揭示KRAS抑制剂反应的差异,并识别更有效的药物组合。

Yu, Johnny X; Suh, Jung Min; Popova, Katerina D; Garcia, Kristle; Joshi, Tanvi; Culbertson, Bruce; Spinelli, Jessica B; Subramanyam, Vishvak; Lou, Kevin; Charbonneau, Trey; Shokat, Kevan M; Weissman, Jonathan; Goodarzi, Hani

A Dimeric Rocaglate Promotes Multivalent eIF4A-RNA Assembly.

二聚体罗卡格酸酯促进多价eIF4A-RNA组装。

Liu Jie, Moore Megan K, Lou Kevin, Wassarman Douglas R, Arab Abolfazl, Ojeda Samuel, Karakyriakou Barbara, Koglin Ann-Sophie, Ott Christopher J, Gilbert Luke A, Shokat Kevan M

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity

脱氮鸟苷酸化是核碱基与蛋白质结合所必需的IV型CBASS免疫反应。

Wassarman, Douglas R; Pfaff, Patrick; Paulo, Joao A; Gygi, Steven P; Shokat, Kevan M; Kranzusch, Philip J

HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma.

HBV通过重塑PP2A复合物来重新连接肝细胞癌中的激酶信号通路

Turnham Rigney E, Pitea Adriana, Jang Gwendolyn M, Xu Zhong, Lim Huat Chye, Choi Alex L, Von Dollen John, Levin Rebecca S, Webber James T, McCarthy Elizabeth, Hu Junjie, Li Xiaolei, Che Li, Singh Ananya, Yoon Alex, Chan Gary K L, Kelley Robin K, Swaney Danielle L, Zhang Wei, Bandyopadhyay Sourav, Theis Fabian J, Eckhardt Manon, Chen Xin, Shokat Kevan M, Ideker Trey, Krogan Nevan J, Gordan John D

Denitrogenative Alkylation of K-Ras(G12D) Inhibits Oncogenic Signaling in Cancer Cells

K-Ras(G12D)的脱氮烷基化抑制癌细胞中的致癌信号传导

Zheng, Qinheng; Shokat, Kevan M

Distal Covalent Targeting Suppresses Signaling of Oncogenic K-Ras(G13C) in Cancer Cells.

远端共价靶向抑制癌细胞中致癌 K-Ras(G13C) 的信号传导

Zheng Qinheng, Shen Tianfang, Pampel Julius, Shokat Kevan M

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity

脱氮鸟苷酸化是核碱基与蛋白质结合所必需的IV型CBASS免疫反应。

Wassarman, Douglas R; Pfaff, Patrick; Paulo, Joao A; Gygi, Steven P; Shokat, Kevan M; Kranzusch, Philip J

Single-sequence deep learning delivers crystal-quality models of covalent K-Ras G12 hotspot complexes

单序列深度学习构建出晶体质量的共价K-Ras G12热点复合物模型

Jung, Sungwon; Zheng, Qinheng; Shokat, Kevan M

Genome-wide CRISPR screens identify PTGES3 as a novel AR modulator

全基因组 CRISPR 筛选鉴定出 PTGES3 是一种新型 AR 调节因子

Li, Haolong; Melnyk, James E; Fu, Becky Xu Hua; Shrestha, Raunak; Zhang, Meng; Sjöström, Martin; Feng, Siyu; Anderson, Jasmine A; Han, Wanting; Chesner, Lisa N; Shin, Hyun Jin; Farsh, Tatyanah; Suarez, Humberto J; Nath, Seema; Chou, Jonathan; Das, Rajdeep; Egusa, Emily A; Zhu, Jun; Winters, Aidan; Maheshwari, Ashutosh; Hua, Junjie T; Alshalalfa, Mohammed; Chen, William S; Calvert, Marsha; Davicioni, Elai; Kishishita, Audrey; Barpanda, Abhilash; Liu, Tianyi; Wiita, Arun P; Stohr, Bradley A; Siddiqui, Javed; Huang, Bo; Small, Eric J; Shokat, Kevan M; Nelson, Peter; Quigley, David A; Wasmuth, Elizabeth V; Gilbert, Luke A; Feng, Felix Y