日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase I study of ribociclib (CDK4/6 inhibitor) with spartalizumab (PD-1 inhibitor) with and without fulvestrant in metastatic hormone receptor-positive breast cancer or advanced ovarian cancer

一项针对转移性激素受体阳性乳腺癌或晚期卵巢癌患者的I期研究,评估了ribociclib(CDK4/6抑制剂)联合spartalizumab(PD-1抑制剂)以及单独使用或不联合fulvestrant的疗效。

Ana C Garrido-Castro ,Noah Graham ,Lestat R Ali ,Christina Herold ,Jennifer Desrosiers ,Khanh Do ,Heather Parsons ,Tianyu Li ,Shom Goel ,Molly DiLullo ,Eileen Wrabel ,Amy J Williams ,Joyce F Liu ,Elizabeth A Mittendorf ,Stephanie K Dougan ,Nabihah Tayob ,Geoffrey I Shapiro ,Sara M Tolaney

INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors

INX-315 是一种选择性 CDK2 抑制剂,可诱导实体瘤细胞周期停滞和衰老。

Catherine Dietrich # ,Alec Trub # ,Antonio Ahn ,Michael Taylor ,Krutika Ambani ,Keefe T Chan ,Kun-Hui Lu ,Christabella A Mahendra ,Catherine Blyth ,Rhiannon Coulson ,Susanne Ramm ,April C Watt ,Sunil Kumar Matsa ,John Bisi ,Jay Strum ,Patrick Roberts ,Shom Goel

The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects

CD8+ T细胞耐受检查点触发一种独特的细胞分化状态,该状态的特征是蛋白质翻译缺陷。

Willem Van Der Byl ,Simone Nüssing ,Timothy J Peters ,Antonio Ahn ,Hanjie Li ,Guy Ledergor ,Eyal David ,Andrew S Koh ,Mayura V Wagle ,Christian Deo T Deguit ,Maria N de Menezes ,Avraham Travers ,Shienny Sampurno ,Kelly M Ramsbottom ,Rui Li ,Axel Kallies ,Paul A Beavis ,Ralf Jungmann ,Maartje M C Bastings ,Gabrielle T Belz ,Shom Goel ,Joseph A Trapani ,Gerald R Crabtree ,Howard Y Chang ,Ido Amit ,Chris C Goodnow ,Fabio Luciani ,Ian A Parish

PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer

PD-1阻断和CDK4/6抑制增强了癌症中T细胞活化的非重叠特征。

Lestat R Ali ,Ana C Garrido-Castro ,Patrick J Lenehan ,Naima Bollenrucher ,Courtney T Stump ,Michael Dougan ,Shom Goel ,Geoffrey I Shapiro ,Sara M Tolaney ,Stephanie K Dougan

Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation

抑制 CDK4/6 可促进 CD8 T 细胞记忆的形成

Max Heckler # ,Lestat R Ali # ,Eleanor Clancy-Thompson ,Li Qiang ,Katherine S Ventre ,Patrick Lenehan ,Kevin Roehle ,Adrienne Luoma ,Kelly Boelaars ,Vera Peters ,Julia McCreary ,Tamara Boschert ,Eric S Wang ,Shengbao Suo ,Francesco Marangoni ,Thorsten R Mempel ,Henry W Long ,Kai W Wucherpfennig ,Michael Dougan ,Nathanael S Gray ,Guo-Cheng Yuan ,Shom Goel ,Sara M Tolaney ,Stephanie K Dougan

CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity

CDK4/6抑制剂通过刺激AP-1转录活性来重编程乳腺癌增强子图谱。

April C Watt # ,Paloma Cejas # ,Molly J DeCristo # ,Otto Metzger-Filho ,Enid Y N Lam ,Xintao Qiu ,Haley BrinJones ,Nikolas Kesten ,Rhiannon Coulson ,Alba Font-Tello ,Klothilda Lim ,Raga Vadhi ,Veerle W Daniels ,Joan Montero ,Len Taing ,Clifford A Meyer ,Omer Gilan ,Charles C Bell ,Keegan D Korthauer ,Claudia Giambartolomei ,Bogdan Pasaniuc ,Ji-Heui Seo ,Matthew L Freedman ,Cynthia Ma ,Matthew J Ellis ,Ian Krop ,Eric Winer ,Anthony Letai ,Myles Brown ,Mark A Dawson ,Henry W Long ,Jean J Zhao ,Shom Goel

Best Practices for Spatial Profiling for Breast Cancer Research with the GeoMx® Digital Spatial Profiler

使用 GeoMx® 数字空间剖析器进行乳腺癌研究空间剖析的最佳实践

Helga Bergholtz, Jodi M Carter, Alessandra Cesano, Maggie Chon U Cheang, Sarah E Church, Prajan Divakar, Christopher A Fuhrman, Shom Goel, Jingjing Gong, Jennifer L Guerriero, Margaret L Hoang, E Shelley Hwang, Hellen Kuasne, Jinho Lee, Yan Liang, Elizabeth A Mittendorf, Jessica Perez, Aleix Prat, L

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

评估乳腺癌基质肿瘤浸润淋巴细胞 (sTIL) 的陷阱

Zuzana Kos, Elvire Roblin, Rim S Kim, Stefan Michiels, Brandon D Gallas, Weijie Chen, Koen K van de Vijver, Shom Goel, Sylvia Adams, Sandra Demaria, Giuseppe Viale, Torsten O Nielsen, Sunil S Badve, W Fraser Symmans, Christos Sotiriou, David L Rimm, Stephen Hewitt, Carsten Denkert, Sibylle Loibl, St

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

FLNB中的一种替代剪接开关促进人乳腺癌中间质细胞的状态

Ji Li # ,Peter S Choi # ,Christine L Chaffer ,Katherine Labella ,Justin H Hwang ,Andrew O Giacomelli ,Jong Wook Kim ,Nina Ilic ,John G Doench ,Seav Huong Ly ,Chao Dai ,Kimberly Hagel ,Andrew L Hong ,Ole Gjoerup ,Shom Goel ,Jennifer Y Ge ,David E Root ,Jean J Zhao ,Angela N Brooks ,Robert A Weinberg ,William C Hahn

CDK4/6 inhibition triggers anti-tumour immunity

CDK4/6抑制可触发抗肿瘤免疫

Shom Goel, Molly J DeCristo, April C Watt, Haley BrinJones, Jaclyn Sceneay, Ben B Li, Naveed Khan, Jessalyn M Ubellacker, Shaozhen Xie, Otto Metzger-Filho, Jeremy Hoog, Matthew J Ellis, Cynthia X Ma, Susanne Ramm, Ian E Krop, Eric P Winer, Thomas M Roberts, Hye-Jung Kim, Sandra S McAllister, Jean J