日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase Ia study to evaluate RO7497987, a FLT3L-fragment Fc fusion protein, in healthy volunteers

在健康志愿者中评估 FLT3L 片段 Fc 融合蛋白 RO7497987 的 Ia 期研究

Iacovelli, Anthony J; Sanjabi, Shomyseh; Monemi, Sharareh; Amitai, Assaf; Decalf, Jérémie; Moussion, Christine; Liao, Michael Z; Rao, Gautham K; Getz, Jennifer; Mancuso, Michael R

Effectorless Fc-fusion improves FLT3L drug-like properties for cancer immunotherapy combinations

无效应分子Fc融合蛋白可改善FLT3L的类药特性,用于癌症免疫疗法组合。

Jérémie Decalf ,Evangeline Toy ,Dongping He ,Radhika Kenkre ,Amy M Berkley ,Devon Wong ,Mandy Kwong ,Yee-Seir Kee ,Yue Sun ,Srividya Myneni ,Xiangdan Wang ,Ahmad Ebtikar ,Anthony Ancheta ,Yanli Yang ,Hok Seon Kim ,Nga Tang ,Debarko Banerji ,Elaine Mai ,Pranay Dogra ,Meredith McLerie ,Alan G Gutierrez ,Geraldine Strasser ,Gautham K Rao ,Matt Betzenhauser ,Wilson Phung ,Peter Day ,Wendy Sandoval ,Ayse Meric Ovacik ,Pamela Chan ,Shomyseh Sanjabi ,Laetitia Comps-Agrar ,Sivan Cohen ,James A Ernst ,Greg A Lazar ,Christopher C Kemball ,Iraj Hosseini ,Yichin Liu ,Jill M Schartner ,Travis W Bainbridge ,Christine Moussion

Different PD-L1 Assays Reveal Distinct Immunobiology and Clinical Outcomes in Urothelial Cancer

不同的PD-L1检测方法揭示了尿路上皮癌中不同的免疫生物学和临床结果

Matthew D Galsky ,Mark Kockx ,Juliette Roels ,Roos Van Elzen ,Xiangnan Guan ,Kobe Yuen ,Deepali Rishipathak ,Jonathan F Anker ,Sacha Gnjatic ,Sudeh Izadmehr ,Shomyseh Sanjabi ,Robert J Johnston ,Maureen Peterson ,Hartmut Koeppen ,Justin M David ,Saurabh Gupta ,Aristotelis Bamias ,Jose Angel Arranz ,Eiji Kikuchi ,Maria De Santis ,Ian D Davis ,Patrick Williams ,Sandrine Bernhard ,Ira Mellman ,Enrique Grande ,Romain Banchereau ,Sanjeev Mariathasan

Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer

在尿路上皮癌中,顺铂化疗联合阿特珠单抗与卡铂化疗联合阿特珠单抗相比,具有免疫调节作用并能改善预后

Matthew D Galsky ,Xiangnan Guan ,Deepali Rishipathak ,Aaron S Rapaport ,Hesham M Shehata ,Romain Banchereau ,Kobe Yuen ,Eugene Varfolomeev ,Ruozhen Hu ,Chia-Jung Han ,Haocheng Li ,Yuxin Liang ,Domagoj Vucic ,Li Wang ,Jun Zhu ,Haocheng Yu ,Rebecca H Herbst ,Emma Hajaj ,Evgeny Kiner ,Aristotelis Bamias ,Maria De Santis ,Ian D Davis ,José Ángel Arranz ,Eiji Kikuchi ,Sandrine Bernhard ,Patrick Williams ,Chooi Lee ,Ira Mellman ,Shomyseh Sanjabi ,Robert Johnston ,Peter C Black ,Enrique Grande ,Sanjeev Mariathasan

Efbalropendekin Alfa enhances human natural killer cell cytotoxicity against tumor cell lines in vitro

Efbalropendekin Alfa 增强人类自然杀伤细胞对体外肿瘤细胞系的细胞毒性

Hesham M Shehata, Pranay Dogra, Sarah Gierke, Patrick Holder, Shomyseh Sanjabi

Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy

PD1/IL15 的转化 PK/PD 和首次人体剂量选择:用于癌症免疫治疗的工程重组靶向细胞因子

Rajbharan Yadav #, Suzanne Schubbert #, Patrick G Holder, Eugene Y Chiang, Nargess Kiabi, Liz Bogaert, Irene Leung, Rumana Rashid, Kendra N Avery, Christine Bonzon, John R Desjarlais, Shomyseh Sanjabi, Amy Sharma, Michelle Lepherd, Amy Shelton, Pam Chan, Yanqiu Liu, Louis Joslyn, Iraj Hosseini, Eric

Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors

PD-L1/TGFβ联合阻断可促进免疫排斥肿瘤中干细胞样CD8 T细胞的扩增和分化。

Alessandra Castiglioni #,Yagai Yang #,Katherine Williams #,Alvin Gogineni,Ryan S Lane,Amber W Wang,Justin A Shyer,Zhe Zhang,Stephanie Mittman,Alan Gutierrez,Jillian L Astarita,Minh Thai,Jeffrey Hung,Yeqing Angela Yang,Tony Pourmohamad,Patricia Himmels,Marco De Simone,Justin Elstrott,Aude-Hélène Capietto,Rafael Cubas,Zora Modrusan,Wendy Sandoval,James Ziai,Stephen E Gould,Wenxian Fu,Yulei Wang,James T Koerber,Shomyseh Sanjabi,Ira Mellman,Shannon J Turley,Sören Müller

Single-cell analysis reveals clonally expanded tumor-associated CD57+ CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade

单细胞分析显示,克隆扩增的肿瘤相关 CD57+ CD8 T 细胞在对 PD-L1 阻断有反应的转移性尿路上皮癌患者外周富集

Michael Fehlings #, Leesun Kim #, Xiangnan Guan, Kobe Yuen, Alireza Tafazzol, Shomyseh Sanjabi, Oliver A Zill, Deepali Rishipathak, Andrew Wallace, Alessandra Nardin, Siming Ma, Ana Milojkovic, Evan W Newell, Sanjeev Mariathasan, Mahesh Yadav

Single cell genome sequencing of laboratory mouse microbiota improves taxonomic and functional resolution of this model microbial community

对实验室小鼠微生物群进行单细胞基因组测序,可提高该模式微生物群落的分类学和功能分辨率。

Lyalina, Svetlana; Stepanauskas, Ramunas; Wu, Frank; Sanjabi, Shomyseh; Pollard, Katherine S

Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract

RNA传感器低表达会影响女性下生殖道中的寨卡病毒感染。

Shahzada Khan ,Irene Lew ,Frank Wu ,Linda Fritts ,Krystal A Fontaine ,Sakshi Tomar ,Martin Trapecar ,Hesham M Shehata ,Melanie Ott ,Christopher J Miller ,Shomyseh Sanjabi