日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.

确定能够逆转具有朊病毒样结构域的 RNA 结合蛋白的有害相变的 RNA 寡核苷酸。

Guo Lin, Mann Jacob R, Mauna Jocelyn C, Copley Katie E, Wang Hejia, Rubien Jack D, Bergmann Cristian A, Carey Jenny L, Merjane Jessica, Ngo Marilyn, Xu Jiazhen, Odeh Hana M, Lin JiaBei, Lee Bo Lim, Ganser Laura, Robinson Emma, Kim Kevin M, Murthy Anastasia C, Paul Tapas, Portz Bede, Gleixner Amanda M, Diaz Zamia, Smirnov Ashleigh, Padilla George, Lavorando Ellen, Espy Carolann, Shang Yulei, Huang Eric J, Chesi Alessandra, Fawzi Nicolas L, Myong Sua, Donnelly Christopher J, Shorter James

Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy

p38α介导的磷酸化和PRMT1介导的精氨酸甲基化在驱动TDP-43蛋白病中发挥相反的作用

Aikio, Mari; Odeh, Hana M; Wobst, Heike J; Lee, Bo Lim; Chan, Úna; Mauna, Jocelyn C; Mack, Korrie L; Class, Bradley; Ollerhead, Thomas A; Ford, Alice F; Barbieri, Edward M; Cupo, Ryan R; Drake, Lauren E; Smalley, Joshua L; Lin, Yuan-Ta; Lam, Stephanie; Thomas, Reuben; Castello, Nicholas; Baral, Ashmita; Beyer, Jenna N; Najar, Mohd A; Dunlop, John; Gitler, Aaron D; Javaherian, Ashkan; Kaye, Julia A; Burslem, George M; Brown, Dean G; Donnelly, Christopher J; Finkbeiner, Steven; Moss, Stephen J; Brandon, Nicholas J; Shorter, James

Nuclear-import receptors remodel the dilute phase to suppress phase transitions of RNA-binding proteins with prion-like domains

核输入受体重塑稀相,以抑制具有朊病毒样结构域的RNA结合蛋白的相变。

Linsenmeier, Miriam; Shinn, Min Kyung; Mumford, Thomas R; Liu, Vicky; Bugaj, Lukasz J; Pappu, Rohit V; Shorter, James

RNA G-Quadruplexes Function as a Tunable Switch of FUS Phase Separation.

RNA G-四链体作为FUS相分离的可调开关。

Carey Jenny L, Hayashi Miyuki, Welebob Emily, Ganser Laura R, Wang Huan, Buckhaults Kerry, DePierro Jacquelyn A, Shi Zheng, Shorter James, Myong Sua, Haeusler Aaron R, Guo Lin

Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity.

对人类 Hsp70 网络的深入研究揭示了多种分子伴侣保护机制,可以缓冲 TDP-43 的毒性

Barbieri Edward M, Linsenmeier Miriam, Whiteman Katherine R, Cheng Yan, Braganza Sylvanne, Copley Katie E, Miranda-Castrodad Paola, Lewis Brennen, Villafañe Kevin, Amado Defne A, Davidson Beverly L, Shorter James

FUS Mislocalization Rewires a Cortical Gene Network to Drive Cognitive and Behavioral Impairment in ALS.

FUS 定位错误重塑皮层基因网络,导致 ALS 患者出现认知和行为障碍

Cassel Raphaelle, Lorenc Félicie, Bombardier Aurélie, DE Tapia Claudia, Dieterle Stéphane, Gouveia Roque Cláudio, Jackson Christopher A, Stuart-Lopez Geoffrey, Rouaux Caroline, Guillot Simon J, Birling Marie-Christine, Kessler Pascal, Grassano Maurizio, Traynor Bryan, Chio Adriano, Roy Raju, Shorter James, Waldron Fergal M, Gregory Jenna M, Phatnani Hemali, Dupuis Luc, Megat Salim

Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD

核输入受体在ALS/FTD病理阶段转变中扮演着关键角色

Khalil, Bilal; Linsenmeier, Miriam; Smith, Courtney L; Shorter, James; Rossoll, Wilfried

The middle domain of Hsp104 can ensure substrates are functional after processing

Hsp104 的中间结构域可以确保底物在加工后仍具有功能活性。

Buchholz, Hannah E; Dorweiler, Jane E; Guereca, Sam; Wisniewski, Brett T; Shorter, James; Manogaran, Anita L

Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS

由FUS种子聚集和扩散引起的额颞叶痴呆样疾病进展

Vazquez-Sanchez, Sonia; Tilkin, Britt; Gasset-Rosa, Fatima; Zhang, Sitao; Piol, Diana; McAlonis-Downes, Melissa; Artates, Jonathan; Govea-Perez, Noe; Verresen, Yana; Guo, Lin; Cleveland, Don W; Shorter, James; Da Cruz, Sandrine

Regulation of Biomolecular Condensates by Poly(ADP-ribose)

聚(ADP-核糖)对生物分子凝聚体的调控

Rhine, Kevin; Odeh, Hana M; Shorter, James; Myong, Sua