日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype

与组蛋白去乙酰化酶 6 催化通道的独特分子相互作用:模型化学类型的晶体学和生物学表征

Olaoye, Olasunkanmi O; Watson, Paris R; Nawar, Nabanita; Geletu, Mulu; Sedighi, Abootaleb; Bukhari, Shazreh; Raouf, Yasir S; Manaswiyoungkul, Pimyupa; Erdogan, Fettah; Abdeldayem, Ayah; Cabral, Aaron D; Hassan, Muhammad Murtaza; Toutah, Krimo; Shouksmith, Andrew E; Gawel, Justyna M; Israelian, Johan; Radu, Tudor B; Kachhiyapatel, Niyati; de Araujo, Elvin D; Christianson, David W; Gunning, Patrick T

Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia

I/IIb类选择性HDAC抑制剂在急性髓系白血病中表现出良好的口服生物利用度和治疗效果

Shouksmith, Andrew E; Gawel, Justyna M; Nawar, Nabanita; Sina, Diana; Raouf, Yasir S; Bukhari, Shazreh; He, Liying; Johns, Alexandra E; Manaswiyoungkul, Pimyupa; Olaoye, Olasunkanmi O; Cabral, Aaron D; Sedighi, Abootaleb; de Araujo, Elvin D; Gunning, Patrick T

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer

AES-135 的鉴定和表征,一种基于羟肟酸的 HDAC 抑制剂,可延长胰腺癌原位小鼠模型的生存期

Andrew E Shouksmith, Fenil Shah, Michelle L Grimard, Justyna M Gawel, Yasir S Raouf, Mulu Geletu, Angelika Berger-Becvar, Elvin D de Araujo, H Artee Luchman, William L Heaton, David Bakhshinyan, Ashley A Adile, Chitra Venugopal, Thomas O'Hare, Michael W Deininger, Sheila K Singh, Stephen F Konieczny

Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities

解除亲电弹头的武装:在酪氨酸激酶抑制剂(TKI)耐药的慢性粒细胞白血病(CML)细胞系中保持疗效,同时规避药代动力学风险

Ali, Ahmed M; Gómez-Biagi, Rodolfo F; Rosa, David A; Lai, Ping-Shan; Heaton, William L; Park, Ji Sung; Eiring, Anna M; Vellore, Nadeem A; de Araujo, Elvin D; Ball, Dan P; Shouksmith, Andrew E; Patel, Ami B; Deininger, Michael W; O'Hare, Thomas; Gunning, Patrick T