日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Assessing the performance of large language models in literature screening for pharmacovigilance: a comparative study

评估大型语言模型在药物警戒文献筛选中的性能:一项比较研究

Li, Dan; Wu, Leihong; Zhang, Mingfeng; Shpyleva, Svitlana; Lin, Ying-Chi; Huang, Ho-Yin; Li, Ting; Xu, Joshua

Chemo brain or tumor brain - that is the question: the presence of extracranial tumors profoundly affects molecular processes in the prefrontal cortex of TumorGraft mice

化疗脑或肿瘤脑 - 这是个问题:颅外肿瘤的存在深刻影响了 TumorGraft 小鼠前额叶皮质的分子过程

Anna Kovalchuk, Yaroslav Ilnytskyy, Rocio Rodriguez-Juarez, Svitlana Shpyleva, Stepan Melnyk, Igor Pogribny, Amanda Katz, David Sidransky, Olga Kovalchuk, Bryan Kolb

Sex-specific effects of cytotoxic chemotherapy agents cyclophosphamide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus - an aging connection

细胞毒性化疗药物环磷酰胺和丝裂霉素C对前额叶皮层和海马体基因表达、氧化性DNA损伤和表观遗传改变的性别特异性影响——与衰老的关联

Kovalchuk, Anna; Rodriguez-Juarez, Rocio; Ilnytskyy, Yaroslav; Byeon, Boseon; Shpyleva, Svitlana; Melnyk, Stepan; Pogribny, Igor; Kolb, Bryan; Kovalchuk, Olga

Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein

三丁酸甘油酯对肝癌变的抑制作用与抑制 p53-CRM1 相互作用和改变 p53 蛋白的细胞区室化有关

Juliana F Ortega, Aline de Conti, Volodymyr Tryndyak, Kelly S Furtado, Renato Heidor, Maria Aderuza Horst, Laura Helena Gasparini Fernandes, Paulo Eduardo Latorre Martins Tavares, Marta Pogribna, Svitlana Shpyleva, Frederick A Beland, Igor P Pogribny, Fernando Salvador Moreno

MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis

MicroRNA-152 介导的肝转铁蛋白受体 1 失调在肝癌发生中的作用

Iryna Kindrat, Volodymyr Tryndyak, Aline de Conti, Svitlana Shpyleva, Thilak K Mudalige, Tetyana Kobets, Anna M Erstenyuk, Frederick A Beland, Igor P Pogribny

Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum

自闭症小脑中Engrailed-2 (EN-2)启动子中5-羟甲基胞嘧啶水平升高与基因表达增加和MeCP2结合减少有关

James, S J; Shpyleva, S; Melnyk, S; Pavliv, O; Pogribny, I P

Cerebellar oxidative DNA damage and altered DNA methylation in the BTBR T+tf/J mouse model of autism and similarities with human post mortem cerebellum

BTBR T+tf/J 自闭症小鼠模型的小脑氧化性 DNA 损伤和 DNA 甲基化改变及其与人类死后小脑的相似性

Shpyleva, Svitlana; Ivanovsky, Samuil; de Conti, Aline; Melnyk, Stepan; Tryndyak, Volodymyr; Beland, Frederick A; James, S Jill; Pogribny, Igor P

Complex epigenetic regulation of engrailed-2 (EN-2) homeobox gene in the autism cerebellum

自闭症小脑中engrailed-2 (EN-2)同源框基因的复杂表观遗传调控

James, S J; Shpyleva, Svitlana; Melnyk, Stepan; Pavliv, Oleksandra; Pogribny, I P

Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents

铁螯合调节细胞内铁代谢会影响乳腺癌细胞中的染色质重塑蛋白和相应的表观遗传修饰,并增加其对化疗药物的敏感性

Igor P Pogribny, Volodymyr P Tryndyak, Marta Pogribna, Svitlana Shpyleva, Gordon Surratt, Gonçalo Gamboa da Costa, Frederick A Beland

Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver

长期服用2-乙酰氨基芴会改变大鼠肝脏细胞的铁代谢。

Shpyleva, Svitlana I; Muskhelishvili, Levan; Tryndyak, Volodymyr P; Koturbash, Igor; Tokar, Erik J; Waalkes, Michael P; Beland, Frederick A; Pogribny, Igor P