日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Drug repurposing screen identifies an HRI activating compound that promotes adaptive mitochondrial remodeling in MFN2-deficient cells.

药物再利用筛选发现了一种 HRI 激活化合物,该化合物可促进 MFN2 缺陷细胞中的线粒体适应性重塑。

Bora Prerona, Zaman Mashiat, Oviedo Samantha, Kutseikin Sergei, Madrazo Nicole, Mathur Prakhyat, Pannikkat Meera, Krasny Sophia, Aldakhlallah Rama, Chu Alan, Johnson Kristen A, Grotjahn Danielle A, Shutt Timothy E, Wiseman R Luke

Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation.

整合应激反应激酶的药理学激活可抑制病理性线粒体碎片化

Baron Kelsey R, Oviedo Samantha, Krasny Sophia, Zaman Mashiat, Aldakhlallah Rama, Bora Prerona, Mathur Prakhyat, Pfeffer Gerald, Bollong Michael J, Shutt Timothy E, Grotjahn Danielle A, Wiseman R Luke

Mitochondria - the CEO of the cell

线粒体——细胞的首席执行官

Lee-Glover, Laurie P; Picard, Martin; Shutt, Timothy E

The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation.

MFN2 Q367H 变异揭示了一种与 mtDNA 介导的炎症相关的新的致病机制

Zaman Mashiat, Sharma Govinda, Almutawa Walaa, Soule Tyler Gb, Sabouny Rasha, Joel Matt, Mohan Armaan, Chute Cole, Joseph Jeffrey T, Pfeffer Gerald, Shutt Timothy E

Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells.

药物再利用筛选发现了一种 HRI 激活化合物,该化合物可促进 MFN2 缺陷细胞中的线粒体适应性重塑

Bora Prerona, Zaman Mashiat, Oviedo Samantha, Kutseikin Sergei, Madrazo Nicole, Mathur Prakhyat, Pannikkat Meera, Krasny Sophia, Chu Alan, Johnson Kristen A, Grotjahn Danielle A, Shutt Timothy E, Wiseman R Luke

Valosin-Containing Protein (VCP): A Review of Its Diverse Molecular Functions and Clinical Phenotypes

含缬氨酸蛋白(VCP):其多种分子功能和临床表型综述

Pontifex, Carly S; Zaman, Mashiat; Fanganiello, Roberto D; Shutt, Timothy E; Pfeffer, Gerald

Mitochondrial DNA release and sensing in innate immune responses

先天免疫反应中的线粒体DNA释放和感知

VanPortfliet, Jordyn J; Chute, Cole; Lei, Yuanjiu; Shutt, Timothy E; West, A Phillip

Mitochondrial Protein Homeostasis and Cardiomyopathy

线粒体蛋白稳态与心肌病

Wachoski-Dark, Emily; Zhao, Tian; Khan, Aneal; Shutt, Timothy E; Greenway, Steven C

The Role of Impaired Mitochondrial Dynamics in MFN2-Mediated Pathology

线粒体动力学受损在MFN2介导的病理学中的作用

Zaman, Mashiat; Shutt, Timothy E

Impact of experimental colitis on mitochondrial bioenergetics in intestinal epithelial cells

实验性结肠炎对肠上皮细胞线粒体生物能量学的影响

Goudie, Luke; Mancini, Nicole L; Shutt, Timothy E; Holloway, Graham P; Mu, Chunlong; Wang, Arthur; McKay, Derek M; Shearer, Jane