日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases

神经退行性疾病单细胞转录组图谱的比较分析

Shwab, E Keats; Man, Zhaohui; Gingerich, Daniel C; Gamache, Julia; Garrett, Melanie E; Serrano, Geidy E; Beach, Thomas G; Crawford, Gregory E; Ashley-Koch, Allison E; Chiba-Falek, Ornit

Leveraging multiomic approaches to elucidate mechanisms of heterogeneity in Alzheimer's disease: Neuropsychiatric symptoms, co-pathologies, and sex differences

利用多组学方法阐明阿尔茨海默病异质性机制:神经精神症状、共病及性别差异

Shwab, E Keats; Pathak, Gita A; Harvey, Joshua; Belloy, Michael E; Fischer, Corinne E; Lutz, Michael W; Scholz, Sonja W; Cook, Noah; Reid, Danielle M; Chen, Jingchun; Guan, Dylan X; Oliveira, Fabricio; Sinclair, Lindsey I; Imo, Uzochukwu; Creese, Byron; Chiba-Falek, Ornit

Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

阿尔茨海默病中小胶质细胞易发生衰老和胆固醇失调

Li, Boyang; Wang, Shaowei; Kerman, Bilal; Hugo, Cristelle; Shwab, E Keats; Shu, Chang; Chiba-Falek, Ornit; Arvanitakis, Zoe; N Yassine, Hussein

Single cell transcriptomics reveals enrichment of aggregation-prone alpha-synuclein isoforms across synucleinopathies

单细胞转录组学揭示了易聚集α-突触核蛋白亚型在突触核蛋白病中的富集

Shwab, E Keats; Pierson, Webb; Gingerich, Daniel C; Man, Zhaohui; Margalit, Sapir; Yona, Dean; Sivan, Asaf; Gamache, Julia; Serrano, Geidy E; Beach, Thomas G; Ebenstein, Yuval; Beck, Roy; Chiba-Falek, Ornit

Single-nucleus multi-omics of Parkinson's disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks

帕金森病单核多组学研究揭示了一种谷氨酸能神经元亚型,该亚型易受转录网络改变导致的基因失调的影响。

Shwab, E Keats; Gingerich, Daniel C; Man, Zhaohui; Gamache, Julia; Garrett, Melanie E; Crawford, Gregory E; Ashley-Koch, Allison E; Serrano, Geidy E; Beach, Thomas G; Lutz, Michael W; Chiba-Falek, Ornit

Title: Reducing APOE4 in carriers is a therapeutic goal for Alzheimer Disease: Report of the APOE4 National Institute on Aging (NIA) /Alzheimer Disease Sequencing Project (ADSP) Consortium Working Group

标题:降低携带者体内 APOE4 水平是阿尔茨海默病治疗的目标:APOE4 美国国家老龄研究所 (NIA) / 阿尔茨海默病测序项目 (ADSP) 联盟工作组报告

de Paula França Resende, Elisa; Lara, Vivian P; Santiago, Ana Luisa C; Friedlaender, Clarisse V; Rosen, Howard J; Brown, Jesse A; Cobigo, Yann; Silva, Lênio L G; Cruz de Souza, Leonardo; Rincon, Luciana; Grinberg, Lea T; Maciel, Francisca I P; Caramelli, Paulo; Sidenkova, A; Luchsinger, Jose A; Vahid, Amirali; Zamani, Jafar; Hosseini, Hadi; Shwab, Elliot Keats; Man, Zhaohui; Gingerich, Daniel; Garrett, Melanie E; Crawford, Gregory; Ashley‐Koch, Allison; Chiba‐Falek, Ornit; Gozdas, Elveda; Hosseini, Hadi; Kueck, Paul J; Honea, Robyn A; Kemna, Riley E; Burns, Jeffrey M; Morris, Jill K; Willette, Auriel A; Kota, Karthik; Hu, William T; Faulkner, Mary E; Gong, Zhaoyuan; Bilgel, Murat; Laporte, John P; Guo, Alex; Bae, Jonghyun; Elango, Palchamy; Bergeron, Christopher M; Bouhrara, Mustapha; Cai, Yue; Fang, Lili; Li, Anqi; Zhou, Xin; Yang, Jie; Guo, Tengfei; Tosun, Duygu; Landau, Susan M; Weiner, Michael S W; Blauwendraat, Cornelis; Meghdadi, Amir H; Verma, Ajay; Mendez, Mario F; Berka, Chris; Sintini, Irene; Ali, Farwa; Stephens, Yehkyoung C; Clark, Heather M; Stierwalt, Julie AG; Josephs, Keith A; Whitwell, Jennifer L; Motaghi, Mahboubeh; Potvin, Olivier; Turcotte, Valérie; Beheshti, Iman; Duchesne, Simon; Guimaraes, Thais Rafael; MacDonald, Matthew L; Thathiah, Amantha; Sharma, Archna; Aylar, Dilara; Lee, Yongchan; Brenner, Max; Marambaud, Philippe; Wang, Ping; Zawar, Ifrah; Quigg, Mark S; Manning, Carol A; kapur, jaideep; Zhuang, Xiaowei; Cordes, Dietmar; Caldwell, Jessica ZK; Bender, Andrew R; Miller, Justin B; Grant, Nicole; Phillips, Natalie; Mitolo, Micaela; Lombardi, Gemma; Manca, Riccardo; Nacmias, Benedetta; Venneri, Annalena; Dong, Mengjin; Xie, Long; Wisse, Laura; de Flores, Robin; Das, Sandhitsu R; Wolk, David A; Yushkevich, Paul A; Motaghi, Mahboubeh; Potvin, Olivier; Turcotte, Valérie; Beheshti, Iman; Duchesne, Simon; Taira, Makiko; Fuse, Nobuo; Saykin, Andrew J; Nagami, Fuji; Kinoshita, Kengo; Yamamoto, Masayuki; Chapin, Benjamin A; Kimmett, Faith; Garvan, Cynthia; Tighe, Patrick; Dekosky, Steven; Williamson, John B; Price, Catherine C; Ekström, Ingrid; Avelar‐Pereira, Bárbara; Ruane, Robert; Grande, Giulia; Fratiglioni, Laura; Larsson, Maria; Laukka, Erika J; Iacovino, Najara; Tondelli, Manuela; Carbone, Chiara; Gallingani, Chiara; Molinari, Maria Angela; Chiari, Annalisa; Zamboni, Giovanna; Tang, Chengyun; Burns, Emily; Border, Jane J; Bunn, David; Cantwell, Cameron; Gregory, Andrew; Johnson, Claire; Dong, Yanbin; Roman, Richard J; Mattson, David L; Fan, Fan; Qi, Le; Pedicone, Chiara; Bowles, Kathryn; Yin, Jiani; Goate, Alison M; Geschwind, Daniel H; Taira, Makiko; Fuse, Nobuo; Saykin, Andrew J; Nagami, Fuji; Kinoshita, Kengo; Yamamoto, Masayuki; Phillips, Natalie; Best, Paul T; Grant, Nicole; Kabir, Ameera; Peña‐Tauber, Andrés; Arriaza, Ricardo Hernandez; Guen, Yann Le; Khosla, Chaitan; Greicius, Michael D; Vashishth, Anushka; Vance, Jeffery M; Holtzman, David M

Microglia States are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

阿尔茨海默病中小胶质细胞易发生衰老和胆固醇失调

Li, Boyang; Wang, Shaowei; Kerman, Bilal; Hugo, Cristelle; Shwab, E Keats; Shu, Chang; Chiba-Falek, Ornit; Arvanitakis, Zoe; Yassine, Hussein

Integrative single-nucleus multi-omics analysis prioritizes candidate cis and trans regulatory networks and their target genes in Alzheimer's disease brains

整合单核多组学分析优先筛选阿尔茨海默病脑组织中的候选顺式和反式调控网络及其靶基因

Gamache, Julia; Gingerich, Daniel; Shwab, E Keats; Barrera, Julio; Garrett, Melanie E; Hume, Cordelia; Crawford, Gregory E; Ashley-Koch, Allison E; Chiba-Falek, Ornit

Protein Kinase A Regulates Autophagy-Associated Proteins Impacting Growth and Virulence of Aspergillus fumigatus

蛋白激酶A调节自噬相关蛋白,从而影响烟曲霉的生长和毒力

Shwab, E Keats; Juvvadi, Praveen R; Shaheen, Shareef K; Allen, John 4th; Waitt, Greg; Soderblom, Erik J; Asfaw, Yohannes G; Moseley, M Arthur; Steinbach, William J

In Vitro Activity of APX2041, a New Gwt1 Inhibitor, and In Vivo Efficacy of the Prodrug APX2104 against Aspergillus fumigatus

新型 Gwt1 抑制剂 APX2041 的体外活性及其前药 APX2104 对烟曲霉的体内疗效

Shaheen, Shareef K; Juvvadi, Praveen R; Allen, John 4th; Shwab, E Keats; Cole, D Christopher; Asfaw, Yohannes G; Kapoor, Mili; Shaw, Karen Joy; Steinbach, William J