日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion

磷酸肌醇 3-激酶 β 中单个离散 Rab5 结合位点是肿瘤细胞侵袭所必需的

Samantha D Heitz, David J Hamelin, Reece M Hoffmann, Nili Greenberg, Gilbert Salloum, Zahra Erami, Bassem D Khalil, Aliaksei Shymanets, Elizabeth A Steidle, Grace Q Gong, Bernd Nürnberg, John E Burke, Jack U Flanagan, Anne R Bresnick, Jonathan M Backer

Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins

鼠伤寒沙门氏菌效应物 SseI 通过对异三聚体 Gi 蛋白进行脱酰胺作用来抑制趋化性并增加宿主细胞存活率

Thorsten Brink, Veronika Leiss, Peter Siegert, Doris Jehle, Julia K Ebner, Carsten Schwan, Aliaksei Shymanets, Sebastian Wiese, Bernd Nürnberg, Michael Hensel, Klaus Aktories, Joachim H C Orth

Rac1-stimulated macropinocytosis enhances Gβγ activation of PI3Kβ

Rac1 刺激的巨胞饮作用增强 Gβγ 对 PI3Kβ 的激活

Zahra Erami, Bassem D Khalil, Gilbert Salloum, Yanhua Yao, Jaclyn LoPiccolo, Aliaksei Shymanets, Bernd Nürnberg, Anne R Bresnick, Jonathan M Backer

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity

单克隆抗体对 Gβγ 刺激的 IB 类磷酸肌醇 3-激酶 (PI3K) 变体的不同抑制。p101 作为 Gβγ 依赖的 PI3Kγ 酶活性调节剂的特定功能

Aliaksei Shymanets, Prajwal, Oscar Vadas, Cornelia Czupalla, Jaclyn LoPiccolo, Michael Brenowitz, Alessandra Ghigo, Emilio Hirsch, Eberhard Krause, Reinhard Wetzker, Roger L Williams, Christian Harteneck, Bernd Nürnberg

p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase

p21 活化激酶 (PAK) 介导 PREX2 蛋白的磷酸化,从而启动 Rac1 GTPase 的反馈抑制

Douglas Barrows, Sarah M Schoenfeld, Cindy Hodakoski, Antonina Silkov, Barry Honig, Anthony Couvillon, Aliaksei Shymanets, Bernd Nürnberg, John M Asara, Ramon Parsons

Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1

脂质体重建以及重组异戊烯基化人 Rac1 由 GEF、GDI1 和 Pak1 调节

Si-Cai Zhang, Lothar Gremer, Henrike Heise, Petra Janning, Aliaksei Shymanets, Ion C Cirstea, Eberhard Krause, Bernd Nürnberg, Mohammad Reza Ahmadian

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

G蛋白偶联受体(GPCR)下游PI3Kγ介导激活的分子决定因素

Vadas, Oscar; Dbouk, Hashem A; Shymanets, Aliaksei; Perisic, Olga; Burke, John E; Abi Saab, Widian F; Khalil, Bassem D; Harteneck, Christian; Bresnick, Anne R; Nürnberg, Bernd; Backer, Jonathan M; Williams, Roger L

p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity

p87 和 p101 亚基是决定 IB 类磷酸肌醇 3-激酶 (PI3K) 特异性的不同调节剂

Aliaksei Shymanets, Prajwal, Kirsten Bucher, Sandra Beer-Hammer, Christian Harteneck, Bernd Nürnberg

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness

G蛋白偶联受体介导的Gβγ对p110β的激活是细胞转化和侵袭所必需的。

Dbouk, Hashem A; Vadas, Oscar; Shymanets, Aliaksei; Burke, John E; Salamon, Rachel S; Khalil, Bassem D; Barrett, Mathew O; Waldo, Gary L; Surve, Chinmay; Hsueh, Christine; Perisic, Olga; Harteneck, Christian; Shepherd, Peter R; Harden, T Kendall; Smrcka, Alan V; Taussig, Ronald; Bresnick, Anne R; Nürnberg, Bernd; Williams, Roger L; Backer, Jonathan M

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma

Ras是IB类磷脂酰肌醇3-激酶p87/p110γ不可或缺的共调节因子。

Kurig, Barbara; Shymanets, Aliaksei; Bohnacker, Thomas; Prajwal; Brock, Carsten; Ahmadian, Mohammad Reza; Schaefer, Michael; Gohla, Antje; Harteneck, Christian; Wymann, Matthias P; Jeanclos, Elisabeth; Nürnberg, Bernd