日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates

在非人灵长类动物中,与卡介苗相比,MTBVAC 可诱导更高的抗体滴度和 IgG 亲和力。

Peralta-Álvarez, Marco Polo; Downward, Keya; White, Andrew; Redondo Azema, Hugo; Sibley, Laura; Sarfas, Charlotte; Morrison, Alexandra; Dennis, Mike; Diaz-Santana, Delia; Harris, Stephanie A; Li, Shuailin; Puentes, Eugenia; Aguilo, Nacho; Martin, Carlos; Sharpe, Sally; McShane, Helen; Tanner, Rachel

Immune cell population dynamics following neonatal BCG vaccination and aerosol BCG revaccination in rhesus macaques

恒河猴新生儿接种卡介苗及气溶胶卡介苗复种后免疫细胞群体动态变化

Sibley, Laura; Sarfas, Charlotte; Morrison, Alexandra L; Williams, Jessica; Gkolfinos, Konstantinos; Mabbutt, Adam; Eckworth, William; Lawrence, Steve; Dennis, Mike; White, Andrew; Sharpe, Sally

Intravenous BCG vaccination in non-human primates induces superior serum antibody titers with enhanced avidity and opsonizing capacity compared to the intradermal route

与皮内注射途径相比,非人灵长类动物静脉注射卡介苗可诱导产生更高滴度的血清抗体,且抗体具有更强的亲和力和调理能力。

Peralta Alvarez, Marco Polo; Downward, Keya; White, Andrew; Harris, Stephanie A; Satti, Iman; Li, Shuailin; Morrison, Alexandra; Sibley, Laura; Sarfas, Charlotte; Dennis, Mike; Azema, Hugo Redondo; Sharpe, Sally; McShane, Helen; Tanner, Rachel

Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol in a Cross-Over Cynomolgus Macaque Model of Mycobacterium tuberculosis Infection

在交叉食蟹猴结核分枝杆菌感染模型中测定异烟肼、利福平、吡嗪酰胺和乙胺丁醇的药代动力学和药效学

Sibley, Laura; White, Andrew D; Sarfas, Charlotte; Gullick, Jennie; Gleeson, Fergus; Lanni, Faye; Clark, Simon; Rayner, Emma; Ferrer-Bazaga, Santiago; Ortega-Muro, Fatima; Alameda, Laura; Rullas, Joaquin; Sousa, Veronica; Martinez, Marisa; Angulo-Barturen, Inigo; Garcia, Adolfo; Vaquero, Juan José; Pertinez, Henry E; Davies, Geraint; Dennis, Mike; Williams, Ann; Sharpe, Sally

Characterization of the Infant Immune System and the Influence and Immunogenicity of BCG Vaccination in Infant and Adult Rhesus Macaques

婴儿免疫系统的特征以及卡介苗接种对婴幼儿和成年恒河猴的影响和免疫原性

Sarfas, Charlotte; White, Andrew D; Sibley, Laura; Morrison, Alexandra L; Gullick, Jennie; Lawrence, Steve; Dennis, Mike J; Marsh, Philip D; Fletcher, Helen A; Sharpe, Sally A

One or two dose regimen of the SARS-CoV-2 synthetic DNA vaccine INO-4800 protects against respiratory tract disease burden in nonhuman primate challenge model.

SARS-CoV-2 合成 DNA 疫苗 INO-4800 的一剂或两剂方案可在非人灵长类动物攻毒模型中预防呼吸道疾病负担

Gooch Karen E, Smith Trevor R F, Salguero Francisco J, Fotheringham Susan A, Watson Robert J, Dennis Mike J, Handley Alastair, Humphries Holly E, Longet Stephanie, Tipton Tom, Sarfas Charlotte, Sibley Laura, Slack Gillian S, Rayner Emma, Ryan Kathryn A, Schultheis Katherine, Ramos Stephanie J, White Andrew, Charlton Sue, Sharpe Sally A, Gleeson Fergus, Humeau Laurent M, Hall Yper, Broderick Kate E, Carroll Miles W

MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies

MTBVAC疫苗可保护恒河猴免受结核分枝杆菌气溶胶感染,并诱导与临床研究中观察到的类似的免疫特征。

White, Andrew D; Sibley, Laura; Sarfas, Charlotte; Morrison, Alexandra; Gullick, Jennie; Clark, Simon; Gleeson, Fergus; McIntyre, Anthony; Arlehamn, Cecilia Lindestam; Sette, Alessandro; Salguero, Francisco J; Rayner, Emma; Rodriguez, Esteban; Puentes, Eugenia; Laddy, Dominick; Williams, Ann; Dennis, Mike; Martin, Carlos; Sharpe, Sally

Development of a non-human primate BCG infection model for the evaluation of candidate tuberculosis vaccines

建立非人灵长类动物卡介苗感染模型以评估候选结核病疫苗

Harris, Stephanie A; White, Andrew; Stockdale, Lisa; Tanner, Rachel; Sibley, Laura; Sarfas, Charlotte; Meyer, Joel; Peter, Jonathan; O'Shea, Matthew K; Manjaly Thomas, Zita-Rose; Hamidi, Ali; Satti, Iman; Dennis, Mike J; McShane, Helen; Sharpe, Sally

Mucosal vaccination against tuberculosis using inert bioparticles

利用惰性生物颗粒进行结核病黏膜疫苗接种

Reljic, Rajko; Sibley, Laura; Huang, Jen-Min; Pepponi, Ilaria; Hoppe, Andreas; Hong, Huynh A; Cutting, Simon M