日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

mRNA decay pre-complex assembly drives timely cell-state transitions during differentiation

mRNA衰变前复合物的组装驱动分化过程中细胞状态的及时转变

Hideyuki Komori ,Geeta Rastogi ,John Paul Bugay ,Hua Luo ,Sichun Lin ,Stephane Angers ,Craig A Smibert ,Howard D Lipshitz ,Cheng-Yu Lee

Identification of VISTA regulators in macrophages mediating cancer cell survival

鉴定巨噬细胞中介导癌细胞存活的 VISTA 调节剂

Abdalla M Abdrabou, Sharif U Ahmed, Mengqi Jonathan Fan, Bill T V Duong, Kangfu Chen, Pei-Ying Lo, Julia M Mayes, Fatemeh Esmaeili, Amin GhavamiNejad, Hossein Zargartalebi, Randy Singh Atwal, Sichun Lin, Stephane Angers, Shana O Kelley

Phenotypic targeting using magnetic nanoparticles for rapid characterization of cellular proliferation regulators

使用磁性纳米粒子进行表型靶向以快速表征细胞增殖调节剂

Zongjie Wang, Hansen Wang, Sichun Lin, Stephane Angers, Edward H Sargent, Shana O Kelley

TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells

TMCO1 在乳腺癌中上调,并调节乳腺癌细胞对促凋亡药物的反应

Alice H L Bong, Mélanie Robitaille, Sichun Lin, Amy McCart-Reed, Michael Milevskiy, Stéphane Angers, Sarah J Roberts-Thomson, Gregory R Monteith

The WAVE regulatory complex interacts with Boc and is required for Shh-mediated axon guidance

WAVE调控复合物与Boc相互作用,是Shh介导的轴突导向所必需的。

Nursen Balekoglu ,Jean-Francois Michaud ,Rachelle Sauvé ,Kehinde S Ayinde ,Sichun Lin ,Yijun Liu ,Daniel A Kramer ,Kaiyue Zhang ,Anika Steffen ,Theresia Stradal ,Stephane Angers ,Baoyu Chen ,Patricia T Yam ,Frédéric Charron

The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma

CDK12 抑制剂 SR-4835 可作为分子胶,促进黑色素瘤中的细胞周期蛋白 K 降解

Thibault Houles #, Jonathan Boucher #, Geneviève Lavoie, Graham MacLeod, Sichun Lin, Stephane Angers, Philippe P Roux

FBXW7-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

FBXW7缺失通过诱导有丝分裂灾难使细胞对ATR抑制剂更加敏感

Siobhan O'Brien ,Tajinder Ubhi ,Lucie Wolf ,Krishna Gandhi ,Sichun Lin ,Naz Chaudary ,Neesha C Dhani ,Michael Milosevic ,Grant W Brown ,Stephane Angers

CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma

CDK12 过度活跃,是 BRAF 突变黑色素瘤中的合成致死靶点

Thibault Houles, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, Éric Vaillancourt-Jean, Célia M Guérin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P Roux

Genome-wide in vivo screen of circulating tumor cells identifies SLIT2 as a regulator of metastasis

对循环肿瘤细胞进行全基因组体内筛选,发现SLIT2是转移的调节因子

Fan Xia ,Yuan Ma ,Kangfu Chen ,Bill Duong ,Sharif Ahmed ,Randy Atwal ,David Philpott ,Troy Ketela ,Jennifer Pantea ,Sichun Lin ,Stephane Angers ,Shana O Kelley

SCFFBXW7 regulates G2-M progression through control of CCNL1 ubiquitination

SCFFBXW7 通过调控 CCNL1 泛素化来调节 G2/M 期进程。

Siobhan O'Brien ,Susan Kelso ,Zachary Steinhart ,Stephen Orlicky ,Monika Mis ,Yunhye Kim ,Sichun Lin ,Frank Sicheri ,Stephane Angers