日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair

DHX9 的强效、选择性小分子抑制剂可抑制错配修复缺陷的微卫星不稳定癌症的增殖

期刊:Cancer Research
影响因子:12.5
doi:10.1158/0008-5472.CAN-24-0397
Jennifer Castro, Matthew H Daniels, David Brennan, Brian Johnston, Deepali Gotur, Young-Tae Lee, Kevin E Knockenhauer, Chuang Lu, Jie Wu, Sunaina Nayak, Cindy Collins, Rishabh Bansal, Shane M Buker, April Case, Julie Liu, Shihua Yao, Brian A Sparling, E Allen Sickmier, Serena J Silver, Stephen J Bla
肿瘤
发表日期：2025
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Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9

ATX968 的发现：一种口服有效的 DHX9 变构抑制剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00252
Daniels, Matthew H; Castro, Jennifer; Lee, Young-Tae; Gotur, Deepali; Knockenhauer, Kevin E; Grigoriu, Simina; Lockbaum, Gordon J; Cheong, Jae Eun; Lu, Chuang; Brennan, David; Buker, Shane M; Liu, Julie; Yao, Shihua; Sparling, Brian A; Sickmier, E Allen; Ribich, Scott; Blakemore, Steve J; Silver, Serena J; Boriack-Sjodin, P Ann; Duncan, Kenneth W; Copeland, Robert A
DHX9
发表日期：2025
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Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.

核糖核酸外切酶 XRN1 作为癌症靶点的特性分析以及腺苷-3',5'-二磷酸作为强效酶抑制剂的鉴定

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-025-08005-y
Lockbaum Gordon J, Lynes Maureen M, Shen Sophie A, Liu Julie, Holt Nicholas, Nayak Sunaina P, Knockenhauer Kevin E, Yao Shihua, Sickmier E Allen, Raman Anugraha, Wu Jie, Case April, Shehaj Livia, Buker Shane M, Grigoriu Simina, Ribich Scott, Blakemore Stephen J, Sparling Brian A, Duncan Kenneth W, Copeland Robert A, Silver Serena J, Boriack-Sjodin P Ann
肿瘤
肿瘤免疫
发表日期：2025
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Crystal structures of the DExH-box RNA helicase DHX9

DExH盒RNA解旋酶DHX9的晶体结构

期刊:Acta Crystallographica Section D-Structural Biology
影响因子:3.8
doi:10.1107/S2059798323007611
Lee, Young Tae; Sickmier, E Allen; Grigoriu, Simina; Castro, Jennifer; Boriack-Sjodin, P Ann
DHX9
发表日期：2023
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Crystal structures of human procathepsin H

人类蛋白酶原H的晶体结构

期刊:PLoS One
影响因子:2.9
doi:10.1371/journal.pone.0200374
Yue Hao, Whitney Purtha, Christa Cortesio, Huan Rui, Yan Gu, Hao Chen, E Allen Sickmier, Paolo Manzanillo, Xin Huang
信号转导
Human
发表日期：2018
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Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D

开发对组织蛋白酶D具有更高选择性的2-氨基噁唑啉-3-氮杂呫吨β-淀粉样蛋白裂解酶（BACE）抑制剂

期刊:Medchemcomm
影响因子:
doi:10.1039/c7md00106a
Low, Jonathan D; Bartberger, Michael D; Chen, Kui; Cheng, Yuan; Fielden, Mark R; Gore, Vijay; Hickman, Dean; Liu, Qingyian; Allen Sickmier, E; Vargas, Hugo M; Werner, Jonathan; White, Ryan D; Whittington, Douglas A; Wood, Stephen; Minatti, Ana E
发表日期：2017
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The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance

帕尼单抗 EGFR 复合物揭示出一种克服西妥昔单抗诱导耐药性的结合机制

期刊:PLoS One
影响因子:2.9
doi:10.1371/journal.pone.0163366
E Allen Sickmier, Robert J M Kurzeja, Klaus Michelsen, Mukta Vazir, Evelyn Yang, Andrew S Tasker
EGFR
EGF
发表日期：2016
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Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes

基于理论的强效长效 FGF21 类似物设计，用于治疗 2 型糖尿病

期刊:PLoS One
影响因子:2.9
doi:10.1371/journal.pone.0049345
Randy Hecht, Yue-Sheng Li, Jeonghoon Sun, Ed Belouski, Michael Hall, Todd Hager, Junming Yie, Wei Wang, Dwight Winters, Stephen Smith, Chris Spahr, Lei-Ting Tam, Zhongnan Shen, Shanaka Stanislaus, Narumol Chinookoswong, Yvonne Lau, Allen Sickmier, Mark Leo Michaels, Thomas Boone, Murielle M Véniant,
代谢
糖尿病
发表日期：2012
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Alternative conformations at the RNA-binding surface of the N-terminal U2AF(65) RNA recognition motif

N端U2AF(65) RNA识别基序的RNA结合表面的替代构象

期刊:Journal of Molecular Biology
影响因子:4.5
doi:10.1016/j.jmb.2006.11.077
Thickman, Karen R; Sickmier, E Allen; Kielkopf, Clara L
发表日期：2007
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Structural basis for polypyrimidine tract recognition by the essential pre-mRNA splicing factor U2AF65

必需前 mRNA 剪接因子 U2AF65 识别多聚嘧啶束的结构基础

期刊:Molecular Cell
影响因子:14.5
doi:10.1016/j.molcel.2006.05.025
E Allen Sickmier, Katherine E Frato, Haihong Shen, Shanthi R Paranawithana, Michael R Green, Clara L Kielkopf
信号转导
发表日期：2006
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