Dual intron-targeted CRISPR-Cas9-mediated disruption of the AML RUNX1-RUNX1T1 fusion gene effectively inhibits proliferation and decreases tumor volume in vitro and in vivo
双内含子靶向 CRISPR-Cas9 介导的 AML RUNX1-RUNX1T1 融合基因破坏可在体内和体外有效抑制增殖并减小肿瘤体积
期刊:Leukemia
影响因子:12.8
doi:10.1038/s41375-023-01950-9
Signe Neldeborg #, Johannes Frasez Soerensen #, Charlotte Thornild Møller, Marie Bill, Zongliang Gao, Rasmus O Bak, Kasper Holm, Boe Sorensen, Mette Nyegaard, Yonglun Luo, Peter Hokland, Magnus Stougaard, Maja Ludvigsen, Christian Kanstrup Holm
