日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

N-terminal protein-macrocycles enabled by conjugate addition/ring expansion cascade reactions

通过共轭加成/扩环级联反应构建N端蛋白质大环化合物

Hughes, Owen R; Tufail, Afzaal; Hutton, Esme; Nabarro, Joe; Howarth, Rachel; Yates, Nicholas D; Whitwood, Adrian C; Robson, Craig N; Signoret, Nathalie; Fascione, Martin A; Spicer, Christopher D; Unsworth, William P

Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations

利用交叉醛醇生物偶联技术,通过汇聚合成法构建N端修饰的CCL5趋化因子用于光亲和受体下拉实验

Tufail, Afzaal; Warnes, Matthew E; Signoret, Nathalie; Fascione, Martin A

Harnessing glycofluoroforms for impedimetric biosensing

利用糖基氟化物进行阻抗生物传感

Hewson, Alice R; Lloyd-Laney, Henry O; Keenan, Tessa; Richards, Sarah-Jane; Gibson, Matthew I; Linclau, Bruno; Signoret, Nathalie; Fascione, Martin A; Parkin, Alison

Towards a 'clicked' PSMA targeting gene delivery bioconjugate-polyplex for prostate cancer

面向前列腺癌的“点击式”PSMA靶向基因递送生物偶联物-聚合物复合物

Noble, Amanda R; Akkad, Saeed; Yates, Nicholas D J; Jeffries, James M; Signoret, Nathalie; Fascione, Martin A

Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH

在酸性pH条件下,交叉醛醇OPAL生物偶联反应优于脯氨酸相邻N端α-氧代醛的分子内半缩醛环化反应。

Tufail, Afzaal; Akkad, Saeed; Hatton, Natasha E; Yates, Nicholas D J; Spears, Richard J; Keenan, Tessa; Parkin, Alison; Signoret, Nathalie; Fascione, Martin A

Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug

探索吉西他滨-葡萄糖杂合物作为糖缀合物前药

Porter, Jack; Noble, Amanda R; Signoret, Nathalie; Fascione, Martin A; Miller, Gavin J

A systematic review reveals conflicting evidence for the prevalence of antibodies against the sialic acid 'xenoautoantigen' Neu5Gc in humans and the need for a standardised approach to quantification

系统性综述揭示了关于人类体内针对唾液酸“异种自身抗原”Neu5Gc抗体的普遍性存在相互矛盾的证据,并指出需要一种标准化的定量方法。

Hutton, Esme; Scott, Emma; Robson, Craig N; Signoret, Nathalie; Fascione, Martin A

New insight into a simple high-yielding method for the production of fully folded and functional recombinant human CCL5

一种用于生产完全折叠且具有功能的重组人CCL5的简单高产方法的新见解

Tufail, Afzaal; Akkad, Saeed; Noble, Amanda R; Fascione, Martin A; Signoret, Nathalie

Preparation and Application of an Inexpensive α-Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis

制备及应用一种与Fmoc固相肽合成兼容的廉价α-甲酰甘氨酸结构单元

Yates, Nicholas D J; Warnes, Matthew E; Breetveld, Reuben; Spicer, Christopher D; Signoret, Nathalie; Fascione, Martin

Identification of a protein expression signature distinguishing early from organising diffuse alveolar damage in COVID-19 patients

鉴定一种能够区分 COVID-19 患者早期弥漫性肺泡损伤和组织性弥漫性肺泡损伤的蛋白质表达特征

Ashwin, Helen; Milross, Luke; Wilson, Julie; Majo, Joaquim; Hang Lee, Jimmy Tsz; Calder, Grant; Hunter, Bethany; James, Sally; Lagos, Dimitris; Signoret, Nathalie; Filby, Andrew; Bayraktar, Omer Ali; Fisher, Andrew J; Kaye, Paul M