日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Enhancer hubs govern chromatin topology and Th17 cell identity

增强子中心调控染色质拓扑结构和Th17细胞特性

Siklenka, Keith; Zhang, Chuangchuang; Li, Liqing; Parker, Morgan; Mehta, Naren; Barrera, Alejandro; Venukuttan, Revathy; Crawford, Gregory E; Gersbach, Charles A; Ciofani, Maria; Reddy, Timothy E

Structured Pooling Improves Detection of Rare Regulatory Mutations in Population-Scale Reporter Assays

结构化混合方法可提高群体规模报告基因检测中罕见调控突变的检出率

Dura, Katherine; Siklenka, Keith; Strause, Kari; Morrow, Shauna; Zhang, Chuangchuang; Barrera, Alejandro; Allen, Andrew S; Reddy, Timothy E; Majoros, William H

Comprehensive evaluation of diverse massively parallel reporter assays to functionally characterize human enhancers genome-wide

对多种大规模并行报告基因检测方法进行全面评估,以从全基因组范围内表征人类增强子的功能。

Zhang, Junke; Leung, Alden King-Yung; Zhu, Yutong; Yao, Li; Willis, Avery; Pan, Xiuqi; Ozer, Abdullah; Zhou, Zhou; Siklenka, Keith; Barrera, Alejandro; Liang, Jin; Tippens, Nathaniel D; Reddy, Timothy E; Lis, John T; Yu, Haiyuan

Multicenter integrated analysis of noncoding CRISPRi screens

非编码 CRISPRi 筛选的多中心综合分析

David Yao #, Josh Tycko #, Jin Woo Oh #, Lexi R Bounds #, Sager J Gosai #, Lazaros Lataniotis #, Ava Mackay-Smith, Benjamin R Doughty, Idan Gabdank, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro

Transcriptional and epigenetic regulators of human CD8+ T cell function identified through orthogonal CRISPR screens

通过正交 CRISPR 筛选鉴定人类 CD8+ T 细胞功能的转录和表观遗传调控因子

Sean R McCutcheon, Adam M Swartz, Michael C Brown, Alejandro Barrera, Christian McRoberts Amador, Keith Siklenka, Lucas Humayun, Maria A Ter Weele, James M Isaacs, Timothy E Reddy, Andrew S Allen, Smita K Nair, Scott J Antonia, Charles A Gersbach1

Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function

正交 CRISPR 筛选以识别人类 CD8 T 细胞功能的转录和表观遗传调节剂

Sean R McCutcheon, Adam M Swartz, Michael C Brown, Alejandro Barrera, Christian McRoberts Amador, Keith Siklenka, Lucas Humayun, James M Isaacs, Timothy E Reddy, Smita Nair, Scott Antonia, Charles A Gersbach

Transgenic mice for in vivo epigenome editing with CRISPR-based systems

利用基于 CRISPR 的系统进行体内表观基因组编辑的转基因小鼠

Matthew P Gemberling #, Keith Siklenka #, Erica Rodriguez, Katherine R Tonn-Eisinger, Alejandro Barrera, Fang Liu, Ariel Kantor, Liqing Li, Valentina Cigliola, Mariah F Hazlett, Courtney A Williams, Luke C Bartelt, Victoria J Madigan, Josephine C Bodle, Heather Daniels, Douglas C Rouse, Isaac B Hilt

Sperm histone H3 lysine 4 trimethylation is altered in a genetic mouse model of transgenerational epigenetic inheritance

精子组蛋白 H3 赖氨酸 4 三甲基化在跨代表观遗传的小鼠模型中发生改变

Ariane Lismer, Keith Siklenka, Christine Lafleur, Vanessa Dumeaux, Sarah Kimmins