日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Expanding the toolbox to develop IAP-based degraders of TEAD transcription factors.

扩展工具箱,开发基于 IAP 的 TEAD 转录因子降解剂。

Gupta Nishma, Trainor Nicole, Radwan Mona, Nguyen Stephanie, Duncan Luke, Tang Andrew X, Beveridge Julia, Silke Natasha, Yousef Jumana, Bilgilier Ceren, Wachter Johannes, Greb Peter, Jandova Zuzana, Eliaš Ján, Kopf Sara, Gerstberger Thomas, Stolt-Bergner Peggy, Braun Nina, Weinstabl Harald, McConnell Darryl B, Mauri Federico, Lucet Isabelle S, Silke John, Chessum Nicola E A, Roy Michael J

Intracellular zinc protects tumours from T cell-mediated cytotoxicity

细胞内锌可保护肿瘤免受T细胞介导的细胞毒性作用

Lelliott, Emily J; Naddaf, Jonathan; Ganio, Katherine; Michie, Jessica; Wang, Shelly; Liu, Lin; Silke, Natasha; Ahn, Antonio; Ramsbottom, Kelly M; Brennan, Amelia J; Freeman, Andrew J; Goel, Shom; Vervoort, Stephin J; Kearney, Conor J; Beavis, Paul A; McDevitt, Christopher A; Silke, John; Oliaro, Jane

Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models.

临床 MDR1 抑制剂可增强 Smac 模拟物的生物利用度,从而杀死小鼠 LSC 并提高 AML 模型中的生存率

Morrish Emma, Copeland Anthony, Moujalled Donia M, Powell Jason A, Silke Natasha, Lin Ann, Jarman Kate E, Sandow Jarrod J, Ebert Gregor, Mackiewicz Liana, Beach Jessica A, Christie Elizabeth L, Lewis Alexander C, Pomilio Giovanna, Fischer Karla C, MacPherson Laura, Bowtell David D L, Webb Andrew I, Pellegrini Marc, Dawson Mark A, Pitson Stuart M, Wei Andrew H, Silke John, Brumatti Gabriela

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia.

HoxA9 调控的 Bcl-2 表达介导髓系祖细胞的存活和 HoxA9 依赖性白血病的严重程度

Brumatti Gabriela, Salmanidis Marika, Kok Chung H, Bilardi Rebecca A, Sandow Jarrod J, Silke Natasha, Mason Kylie, Visser Jolanda, Jabbour Anissa M, Glaser Stefan P, Okamoto Toru, Bouillet Philippe, D'Andrea Richard J, Ekert Paul G