日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

DHX9 inhibition enhances paclitaxel sensitivity by inducing mitotic failure in ovarian and endometrial cancers

DHX9抑制剂通过诱导卵巢癌和子宫内膜癌的有丝分裂失败来增强紫杉醇的敏感性。

Huang, Tzu-Ting; Nair, Jayakumar R; Bowen, Courtney; Castro, Jennifer; Nousome, Darryl; Nayak, Sunaina; Silver, Serena J; Lee, Jung-Min

Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9

ATX968 的发现:一种口服有效的 DHX9 变构抑制剂

Daniels, Matthew H; Castro, Jennifer; Lee, Young-Tae; Gotur, Deepali; Knockenhauer, Kevin E; Grigoriu, Simina; Lockbaum, Gordon J; Cheong, Jae Eun; Lu, Chuang; Brennan, David; Buker, Shane M; Liu, Julie; Yao, Shihua; Sparling, Brian A; Sickmier, E Allen; Ribich, Scott; Blakemore, Steve J; Silver, Serena J; Boriack-Sjodin, P Ann; Duncan, Kenneth W; Copeland, Robert A

Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.

核糖核酸外切酶 XRN1 作为癌症靶点的特性分析以及腺苷-3',5'-二磷酸作为强效酶抑制剂的鉴定

Lockbaum Gordon J, Lynes Maureen M, Shen Sophie A, Liu Julie, Holt Nicholas, Nayak Sunaina P, Knockenhauer Kevin E, Yao Shihua, Sickmier E Allen, Raman Anugraha, Wu Jie, Case April, Shehaj Livia, Buker Shane M, Grigoriu Simina, Ribich Scott, Blakemore Stephen J, Sparling Brian A, Duncan Kenneth W, Copeland Robert A, Silver Serena J, Boriack-Sjodin P Ann

Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement

发现驱动蛋白KIF18A抑制剂ATX020:硅原子取代的战术应用

Sparling, Brian A; Lee, Hyelee; Zablocki, Mary-Margaret; Lynes, Maureen M; Grigoriu, Simina; Shehaj, Livia; Lockbaum, Gordon J; Khan, Sanjoy K; Hotz, Taylor; Lee, Young-Tae; Buker, Shane M; Gotur, Deepali; Lu, Chuang; Ribich, Scott; Blakemore, Stephen J; Boriack-Sjodin, P Ann; Silver, Serena J; Copeland, Robert A; Duncan, Kenneth W

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

用于药物筛选的高通量三维肿瘤球体的构建

Griner, Lesley Mathews; Gampa, Kalyani; Do, Toan; Nguyen, Huyen; Farley, David; Hogan, Christopher J; Auld, Douglas S; Silver, Serena J

ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state

ZFHX4 与 NuRD 核心成员 CHD4 相互作用,并调控胶质母细胞瘤肿瘤起始细胞状态。

Chudnovsky, Yakov; Kim, Dohoon; Zheng, Siyuan; Whyte, Warren A; Bansal, Mukesh; Bray, Mark-Anthony; Gopal, Shuba; Theisen, Matthew A; Bilodeau, Steve; Thiru, Prathapan; Muffat, Julien; Yilmaz, Omer H; Mitalipova, Maya; Woolard, Kevin; Lee, Jeongwu; Nishimura, Riko; Sakata, Nobuo; Fine, Howard A; Carpenter, Anne E; Silver, Serena J; Verhaak, Roel G W; Califano, Andrea; Young, Richard A; Ligon, Keith L; Mellinghoff, Ingo K; Root, David E; Sabatini, David M; Hahn, William C; Chheda, Milan G

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

鉴定多倍体化调控因子可为治疗急性髓系白血病(AMKL)提供治疗靶点。

Wen, Qiang; Goldenson, Benjamin; Silver, Serena J; Schenone, Monica; Dancik, Vlado; Huang, Zan; Wang, Ling-Zhi; Lewis, Timothy A; An, W Frank; Li, Xiaoyu; Bray, Mark-Anthony; Thiollier, Clarisse; Diebold, Lauren; Gilles, Laure; Vokes, Martha S; Moore, Christopher B; Bliss-Moreau, Meghan; Verplank, Lynn; Tolliday, Nicola J; Mishra, Rama; Vemula, Sasidhar; Shi, Jianjian; Wei, Lei; Kapur, Reuben; Lopez, Cécile K; Gerby, Bastien; Ballerini, Paola; Pflumio, Francoise; Gilliland, D Gary; Goldberg, Liat; Birger, Yehudit; Izraeli, Shai; Gamis, Alan S; Smith, Franklin O; Woods, William G; Taub, Jeffrey; Scherer, Christina A; Bradner, James E; Goh, Boon-Cher; Mercher, Thomas; Carpenter, Anne E; Gould, Robert J; Clemons, Paul A; Carr, Steven A; Root, David E; Schreiber, Stuart L; Stern, Andrew M; Crispino, John D

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

亚型特异性基因组改变为软组织肉瘤治疗提供了新的靶点

Barretina, Jordi; Taylor, Barry S; Banerji, Shantanu; Ramos, Alexis H; Lagos-Quintana, Mariana; Decarolis, Penelope L; Shah, Kinjal; Socci, Nicholas D; Weir, Barbara A; Ho, Alan; Chiang, Derek Y; Reva, Boris; Mermel, Craig H; Getz, Gad; Antipin, Yevgenyi; Beroukhim, Rameen; Major, John E; Hatton, Charles; Nicoletti, Richard; Hanna, Megan; Sharpe, Ted; Fennell, Tim J; Cibulskis, Kristian; Onofrio, Robert C; Saito, Tsuyoshi; Shukla, Neerav; Lau, Christopher; Nelander, Sven; Silver, Serena J; Sougnez, Carrie; Viale, Agnes; Winckler, Wendy; Maki, Robert G; Garraway, Levi A; Lash, Alex; Greulich, Heidi; Root, David E; Sellers, William R; Schwartz, Gary K; Antonescu, Cristina R; Lander, Eric S; Varmus, Harold E; Ladanyi, Marc; Sander, Chris; Meyerson, Matthew; Singer, Samuel

Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning

利用迭代反馈和机器学习对基于图像的筛选中不同的细胞形态进行评分

Jones, Thouis R; Carpenter, Anne E; Lamprecht, Michael R; Moffat, Jason; Silver, Serena J; Grenier, Jennifer K; Castoreno, Adam B; Eggert, Ulrike S; Root, David E; Golland, Polina; Sabatini, David M

CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

CDK8是一种结直肠癌癌基因,可调节β-catenin活性。

Firestein, Ron; Bass, Adam J; Kim, So Young; Dunn, Ian F; Silver, Serena J; Guney, Isil; Freed, Ellen; Ligon, Azra H; Vena, Natalie; Ogino, Shuji; Chheda, Milan G; Tamayo, Pablo; Finn, Stephen; Shrestha, Yashaswi; Boehm, Jesse S; Jain, Supriya; Bojarski, Emeric; Mermel, Craig; Barretina, Jordi; Chan, Jennifer A; Baselga, Jose; Tabernero, Josep; Root, David E; Fuchs, Charles S; Loda, Massimo; Shivdasani, Ramesh A; Meyerson, Matthew; Hahn, William C