日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Camonsertib, an ATRi, in Combination with Low-Dose Gemcitabine in Solid Tumors with DNA Damage Response Aberrations: Preclinical and Phase Ib Results

Camonsertib(一种ATRi)联合低剂量吉西他滨治疗伴有DNA损伤反应异常的实体瘤:临床前和Ib期研究结果

Rosen, Ezra Y; Yap, Timothy A; Fontana, Elisa; Lee, Elizabeth K; Mahalingam, Devalingam; Højgaard, Martin; Mettu, Niharika B; Cote, Gregory M; Plummer, Ruth; Koehler, Maria; Ulanet, Danielle; Fei, Kezhen; Silverman, Ian M; Schonhoft, Joseph D; Rimkunas, Victoria; Bacque, Emeline S; Gomez, Gabriela; Fretland, Adrian J; Roulston, Anne; Li, Li; Baruah, Prasamit; Zimmermann, Michal; Yang, Julia; Carneiro, Benedito A; Lheureux, Stephanie

Genomic and Epigenomic ctDNA Profiling in Liquid Biopsies from Heavily Pretreated Patients with DNA Damage Response-Deficient Tumors

对接受过大量预处理的DNA损伤反应缺陷型肿瘤患者的液体活检样本进行基因组和表观基因组ctDNA分析

Silverman, Ian M; Schonhoft, Joseph D; Herzberg, Benjamin; Yablonovitch, Arielle; Lagow, Errin; Fiaux, Patrick C; Safabakhsh, Pegah; Sethuraman, Sunantha; Ulanet, Danielle; Yang, Julia; Kim, Insil; Basciano, Paul; Cecchini, Michael; Lee, Elizabeth; Lheureux, Stephanie; Fontana, Elisa; Carneiro, Benedito A; Reis-Filho, Jorge S; Yap, Timothy A; Zinda, Michael; Rosen, Ezra Y; Rimkunas, Victoria

Exceptional response to the ATR inhibitor, camonsertib, in a patient with ALT+ metastatic melanoma

ATR抑制剂camonsertib在一名ALT+转移性黑色素瘤患者中表现出卓越的疗效

Ngoi, Natalie Y L; Silverman, Ian M; Johnson, Adrienne; Meng, Chenfeng; Schonhoft, Joseph D; Zimmermann, Michal; Ulanet, Danielle; Kim, Hyeyeon; Torrado, Carlos; Salguero, Carolina; Brown, Christian Valladolid; Rodon, Jordi; Rimkunas, Victoria; Koehler, Maria; Yap, Timothy A

Ataxia telangiectasia and Rad3-related (ATR) inhibitor camonsertib dose optimization in patients with biomarker-selected advanced solid tumors (TRESR study)

共济失调毛细血管扩张症和 Rad3 相关 (ATR) 抑制剂 camonsertib 在生物标志物选择的晚期实体瘤患者中的剂量优化 (TRESR 研究)

Fontana, Elisa; Rosen, Ezra; Lee, Elizabeth K; Højgaard, Martin; Mettu, Niharika B; Lheureux, Stephanie; Carneiro, Benedito A; Cote, Gregory M; Carter, Louise; Plummer, Ruth; Mahalingam, Devalingam; Fretland, Adrian J; Schonhoft, Joseph D; Silverman, Ian M; Wainszelbaum, Marisa; Xu, Yi; Ulanet, Danielle; Koehler, Maria; Yap, Timothy A

Loss of the DNA Repair Gene RNase H2 Identifies a Unique Subset of DDR-Deficient Leiomyosarcomas

DNA修复基因RNase H2的缺失可识别DDR缺陷型平滑肌肉瘤的一个独特亚群

Nakazawa, Michael S; Silverman, Ian M; Rimkunas, Victoria; Veloso, Artur; Glodzik, Dominik; Johnson, Adrienne; Ohsumi, Toshiro K; Patel, Shreyaskumar R; Conley, Anthony P; Roland, Christina L; Soliman, Pamela T; Beird, Hannah C; Wu, Chia-Chin; Ingram, Davis R; Lazcano, Rossana; Song, Dawon; Wani, Khalida M; Lazar, Alexander J; Yap, Timothy A; Wang, Wei-Lien; Livingston, J Andrew

Detection of Biallelic Loss of DNA Repair Genes in Formalin-Fixed, Paraffin-Embedded Tumor Samples Using a Novel Tumor-Only Sequencing Panel

利用新型肿瘤特异性测序方法检测福尔马林固定、石蜡包埋肿瘤样本中DNA修复基因的双等位基因缺失

Glodzik, Dominik; Selenica, Pier; Rogge, Ryan A; Silverman, Ian M; Mandelker, Diana; Harris, Sam; Zhao, Jianhua; Zinda, Michael; Veloso, Artur; Malani, Nirav; Riaz, Nadeem; Koehler, Maria; Daber, Robert D; Johnson, Verity; Rimkunas, Victoria; Reis-Filho, Jorge S

Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

出版商更正:截短的FGFR2是多种癌症中具有临床意义的癌基因。

Zingg, Daniel; Bhin, Jinhyuk; Yemelyanenko, Julia; Kas, Sjors M; Rolfs, Frank; Lutz, Catrin; Lee, Jessica K; Klarenbeek, Sjoerd; Silverman, Ian M; Annunziato, Stefano; Chan, Chang S; Piersma, Sander R; Eijkman, Timo; Badoux, Madelon; Gogola, Ewa; Siteur, Bjørn; Sprengers, Justin; de Klein, Bim; de Goeij-de Haas, Richard R; Riedlinger, Gregory M; Ke, Hua; Madison, Russell; Drenth, Anne Paulien; van der Burg, Eline; Schut, Eva; Henneman, Linda; van Miltenburg, Martine H; Proost, Natalie; Zhen, Huiling; Wientjens, Ellen; de Bruijn, Roebi; de Ruiter, Julian R; Boon, Ute; de Korte-Grimmerink, Renske; van Gerwen, Bastiaan; Féliz, Luis; Abou-Alfa, Ghassan K; Ross, Jeffrey S; van de Ven, Marieke; Rottenberg, Sven; Cuppen, Edwin; Chessex, Anne Vaslin; Ali, Siraj M; Burn, Timothy C; Jimenez, Connie R; Ganesan, Shridar; Wessels, Lodewyk F A; Jonkers, Jos

Genomic Analysis of Posterior Fossa Meningioma Demonstrates Frequent AKT1 E17K Mutations in Foramen Magnum Meningiomas

后颅窝脑膜瘤的基因组分析显示枕骨大孔脑膜瘤中AKT1 E17K突变频繁发生

Williams, Sally R; Juratli, Tareq A; Castro, Brandyn A; Lazaro, Tyler T; Gill, Corey M; Nayyar, Naema; Strickland, Matthew R; Babinski, Melanie; Johnstone, Sarah E; Frosch, Matthew P; Silverman, Ian M; Ely, Heather A; Kaplan, Alexander B; D'Andrea, Megan R; Bihun, Ivanna V; Hoang, Kaitlin; Batchelor, Emily; Christiansen, Jason; Cahill, Daniel P; Barker, Frederick G 2nd; Brastianos, Priscilla K

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle.

NAD稳态丧失会导致骨骼肌进行性、可逆性退化

Frederick David W, Loro Emanuele, Liu Ling, Davila Antonio Jr, Chellappa Karthikeyani, Silverman Ian M, Quinn William J 3rd, Gosai Sager J, Tichy Elisia D, Davis James G, Mourkioti Foteini, Gregory Brian D, Dellinger Ryan W, Redpath Philip, Migaud Marie E, Nakamaru-Ogiso Eiko, Rabinowitz Joshua D, Khurana Tejvir S, Baur Joseph A

Terpene metabolic engineering via nuclear or chloroplast genomes profoundly and globally impacts off-target pathways through metabolite signalling

通过核基因组或叶绿体基因组进行萜烯代谢工程,会通过代谢物信号传导对脱靶途径产生深远而广泛的影响。

Pasoreck, Elise K; Su, Jin; Silverman, Ian M; Gosai, Sager J; Gregory, Brian D; Yuan, Joshua S; Daniell, Henry