日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Targeting Conformational Flexibility of a Reactive Intermediate to Enhance Selectivity of a GABA Aminotransferase Inactivator

靶向反应中间体的构象柔性以增强GABA氨基转移酶失活剂的选择性

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c21138
Kang, Koon Mook; Vargas, Abigail L; Ferreira, Luana Assis; Des Soye, Benjamin James; Corrigan, Mary; Zhang, Cathy Kexin; Wang, Feng; Duan, Dorothy; Kelleher, Neil L; Hohmann, Andrea G; Liu, Dali; Silverman, Richard B
发表日期：2026
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Polyamine Metabolism and the DHPS/eIF5A Hypusination Axis: From Metabolic Reprogramming to a Therapeutic Achilles’ Heel in Melanoma

多胺代谢与DHPS/eIF5A低硫胺素化轴：从代谢重编程到黑色素瘤治疗的阿喀琉斯之踵

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c02154
Awasthi, Amardeep; Patel, Anika; Li, Huiying; Kang, Koon Mook; Hardy, Christine D; Ansari, Anas; Nowar, Raghad; Hasan, Md Emtiaz; Yang, Sun; Poulos, Thomas L; Silverman, Richard B; Liu, Kai-Li; Zhang, Shuo; Li, Feng-Shuo; Chen, Min-Jin; Chen, Yuan-Yuan; Zhang, Ning; Wang, Kai
代谢重编程
IF5
黑色素瘤
代谢
发表日期：2026
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Enhancement of Potency and Selectivity of 2-Aminoquinoline-Based Human Neuronal Nitric Oxide Synthase Inhibitors

提高2-氨基喹啉类人神经元一氧化氮合酶抑制剂的效力和选择性

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01679
Ansari, Anas; Kang, Koon Mook; Li, Huiying; Hardy, Christine D; Rathnayake, Athri D; Awasthi, Amardeep; Poulos, Thomas L; Silverman, Richard B
Human
神经科学
发表日期：2026
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Potent, Selective, and Brain Penetrant Ether-Linked 2-Aminopyridine Inhibitors of Human Neuronal Nitric Oxide Synthase with Excellent Oral Bioavailability

高效、选择性强、可穿透血脑屏障的醚键连接的2-氨基吡啶类人神经元一氧化氮合酶抑制剂，具有优异的口服生物利用度

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c03568
Ansari, Anas; Chrzanowski, Radoslaw T; Li, Huiying; Hardy, Christine D; Awasthi, Amardeep; Poulos, Thomas L; Silverman, Richard B
血脑屏障
Human
神经科学
发表日期：2026
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Dynamic tail amine interactions drive isoform selectivity for potent human neuronal nitric oxide synthase inhibitors

动态尾胺相互作用驱动强效人类神经元一氧化氮合酶抑制剂的同工酶选择性

期刊:
影响因子:
doi:10.1007/s00044-026-03552-3
Pessoa, Pedro; Pressé, Steve; Ozkan, S Banu; Awasthi, Amardeep; Kang, Koon Mook; Silverman, Richard B
神经科学
发表日期：2026
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Identification of a glia-associated amyloid β oligomer subtype and the rescue from reactive astrogliosis by inhibitor NU-9

鉴定一种与胶质细胞相关的β淀粉样蛋白寡聚体亚型，以及抑制剂NU-9对反应性星形胶质增生的挽救作用

期刊:Alzheimers & Dementia
影响因子:11.1
doi:10.1002/alz.70968
Kranz, Daniel L; de Leon Velez, Omar; Ulupinar, Emel; Ozdinler, P Hande; Silverman, Richard B; Klein, William L
胶质细胞
细胞生物学
发表日期：2025
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Efficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addiction

GABA氨基转移酶抑制剂OV329在神经性疼痛和炎症性疼痛模型中疗效显著，且无耐受性或成瘾性。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2318833121
Wirt, Jonah L; Assis Ferreira, Luana; Jesus, Carlos Henrique Alves; Woodward, Taylor J; Oliva, Idaira; Xu, Zhili; Crystal, Jonathon D; Pepin, Robert H; Silverman, Richard B; Hohmann, Andrea G
炎症/感染
炎症
发表日期：2025
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Inhibition of amyloid beta oligomer accumulation by NU-9: A unifying mechanism for the treatment of neurodegenerative diseases

NU-9抑制β-淀粉样蛋白寡聚体积累：治疗神经退行性疾病的统一机制

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2402117122
Johnson, Elizabeth A; Nowar, Raghad; Viola, Kirsten L; Huang, Weijian; Zhou, Sihang; Bicca, Maíra A; Zhu, Wei; Kranz, Daniel L; Klein, William L; Silverman, Richard B
神经科学
发表日期：2025
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Kinetically Controlled aza-Michael/Epimerization Cascade Enables a Scalable Total Synthesis of Putative (+)-Fumigaclavine F

动力学控制的氮杂迈克尔加成/差向异构化级联反应实现了假定的(+)-富马克拉维F的可扩展全合成

期刊:Organic Letters
影响因子:5
doi:10.1021/acs.orglett.5c03284
Dukes, Adrian O; Weerawarna, Pathum M; Silverman, Richard B
信号转导
发表日期：2025
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Synthesis of Oxabicyclo[3.2.1]octan-3-ol Scaffold via Burgess Reagent Mediated Cyclodehydration of δ-Diols under Acidic Conditions

在酸性条件下，通过伯吉斯试剂介导的δ-二醇环脱水反应合成氧杂双环[3.2.1]辛-3-醇骨架

期刊:Organic Letters
影响因子:5
doi:10.1021/acs.orglett.4c04473
Elmansy, Mohamed F; Dos Remedios, Jose Ricardo D; Silverman, Richard B
发表日期：2025
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