日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery

基于片段的药物发现方法鉴定 RNase L 小分子抑制剂

Tang, Jinle; Dong, Beihua; Liu, Ming; Liu, Shuyan; Niu, Xiaogang; Gaughan, Christina; Asthana, Abhishek; Zhou, Huan; Xu, Zhengshuang; Zhang, Guoliang; Silverman, Robert H; Huang, Hao

Ablation of SigH+ pDCs in B6.Nba2 mice prevents lupus-like disease development only if started before disease is fully established

在B6.Nba2小鼠中,只有在疾病完全确立之前开始清除SigH+ pDCs才能阻止狼疮样疾病的发展。

Campbell, Nicole O; Davison, Laura M; Banerjee, Shuvojit; Nguyen, Jane K; Krafcik, Sarah; Silverman, Robert H; Jorgensen, Trine N

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes

SARS-CoV-2 可诱导呼吸道上皮细胞和心肌细胞中双链 RNA 介导的先天免疫反应。

Li, Yize; Renner, David M; Comar, Courtney E; Whelan, Jillian N; Reyes, Hanako M; Cardenas-Diaz, Fabian Leonardo; Truitt, Rachel; Tan, Li Hui; Dong, Beihua; Alysandratos, Konstantinos Dionysios; Huang, Jessie; Palmer, James N; Adappa, Nithin D; Kohanski, Michael A; Kotton, Darrell N; Silverman, Robert H; Yang, Wenli; Morrisey, Edward E; Cohen, Noam A; Weiss, Susan R

Zika virus employs the host antiviral RNase L protein to support replication factory assembly

寨卡病毒利用宿主抗病毒RNase L蛋白来支持复制工厂的组装。

Whelan, Jillian N; Parenti, Nicholas A; Hatterschide, Joshua; Renner, David M; Li, Yize; Reyes, Hanako M; Dong, Beihua; Perez, Erick R; Silverman, Robert H; Weiss, Susan R

Specificity and Mechanism of Coronavirus, Rotavirus, and Mammalian Two-Histidine Phosphoesterases That Antagonize Antiviral Innate Immunity

冠状病毒、轮状病毒和哺乳动物双组氨酸磷酸酯酶拮抗抗病毒先天免疫的特异性和机制

Asthana, Abhishek; Gaughan, Christina; Dong, Beihua; Weiss, Susan R; Silverman, Robert H

A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency

RNase L 的一种酚类小分子抑制剂可预防 ADAR1 缺陷引起的细胞死亡

Daou, Salima; Talukdar, Manisha; Tang, Jinle; Dong, Beihua; Banerjee, Shuvojit; Li, Yize; Duffy, Nicole M; Ogunjimi, Abiodun A; Gaughan, Christina; Jha, Babal K; Gish, Gerald; Tavernier, Nicolas; Mao, Daniel; Weiss, Susan R; Huang, Hao; Silverman, Robert H; Sicheri, Frank

Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death

2',5'-寡腺苷酸合成酶1抑制PARylation可抑制DNA损伤诱导的细胞死亡

Kondratova, Anna; Cheon, HyeonJoo; Dong, Beihua; Holvey-Bates, Elise G; Hasipek, Metis; Taran, Irina; Gaughan, Christina; Jha, Babal K; Silverman, Robert H; Stark, George R

OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug

OAS-RNase L 先天免疫通路介导 DNA 去甲基化药物的细胞毒性

Banerjee, Shuvojit; Gusho, Elona; Gaughan, Christina; Dong, Beihua; Gu, Xiaorong; Holvey-Bates, Elise; Talukdar, Manisha; Li, Yize; Weiss, Susan R; Sicheri, Frank; Saunthararajah, Yogen; Stark, George R; Silverman, Robert H

Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling

埃及果蝠来源的RoNi/7细胞中RNase L的激活主要依赖于OAS3,而与MAVS信号通路无关。

Li, Yize; Dong, Beihua; Wei, Zuzhang; Silverman, Robert H; Weiss, Susan R

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication

早期内切酶介导的RNA识别逃避确保了冠状病毒的高效复制。

Kindler, Eveline; Gil-Cruz, Cristina; Spanier, Julia; Li, Yize; Wilhelm, Jochen; Rabouw, Huib H; Züst, Roland; Hwang, Mihyun; V'kovski, Philip; Stalder, Hanspeter; Marti, Sabrina; Habjan, Matthias; Cervantes-Barragan, Luisa; Elliot, Ruth; Karl, Nadja; Gaughan, Christina; van Kuppeveld, Frank J M; Silverman, Robert H; Keller, Markus; Ludewig, Burkhard; Bergmann, Cornelia C; Ziebuhr, John; Weiss, Susan R; Kalinke, Ulrich; Thiel, Volker