日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PHI-501, a dual inhibitor of RAF and DDR1/2, overcomes MAPK drug resistance in Melanoma

PHI-501 是一种 RAF 和 DDR1/2 双重抑制剂,可克服黑色素瘤中的 MAPK 药物耐药性。

Kim, Sue Min; Cho, Sungmin; Sung, Gi-Jun; Nam, Ky-Youb; Yoon, JeongHyeok; Sim, Taebo; Ahn, Joong Bae; Shin, Sang Joon

Targeted autophagic clearance of Tau protects against Alzheimer's disease through amelioration of Tau-mediated lysosomal stress.

靶向自噬清除 Tau 蛋白可减轻 Tau 蛋白介导的溶酶体应激,从而预防阿尔茨海默病

Yoon Bo Hyun, Kim Jinho, Sengupta Sandip, Park Chan-Jung, Ko Minjoo, Kang Ji Hee, Ko Young Tag, Kim Yeji, Lim Seung Min, Bae Yoonhee, Choi MooYoung, Jang Yunyeong, Kwon Ho Jeong, Son Hyo Jin, Kim Hee Jin, Sim Taebo, Chang Keun-A, Lee Myung-Shik

Recent progress in emerging molecular targeted therapies for intrahepatic cholangiocarcinoma

肝内胆管癌分子靶向治疗的最新进展

Kim, Younghoon; Song, Jaewon; Kim, Namkyoung; Sim, Taebo

Natural and Synthetic Lactones Possessing Antitumor Activities

具有抗肿瘤活性的天然和合成内酯

Kim, Younghoon; Sengupta, Sandip; Sim, Taebo

Synthesis and structure-activity relationships of targeted protein degraders for the understudied kinase NEK9.

针对研究不足的激酶 NEK9 的靶向蛋白降解剂的合成及构效关系研究

Ryu SeongShick, Gadbois Gillian E, Tao Andrew J, Fram Benjamin J, Jiang Jie, Boyle Bridget, Donovan Katherine A, Krupnick Noah M, Berry Bethany C, Bhunia Debabrata, Shin Injae, Fischer Eric S, Gray Nathanael S, Sim Taebo, Ferguson Fleur M

Correction: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

更正:一种ATP竞争性哺乳动物雷帕霉素靶蛋白抑制剂揭示了mTORC1的雷帕霉素耐药功能

Thoreen, Carson C; Kang, Seong A; Chang, Jae Won; Liu, Qingsong; Zhang, Jianming; Gao, Yi; Reichling, Laurie J; Sim, Taebo; Sabatini, David M; Gray, Nathanael S

Raman-Based in Situ Monitoring of Changes in Molecular Signatures during Mitochondrially Mediated Apoptosis

基于拉曼光谱的线粒体介导细胞凋亡过程中分子特征变化的原位监测

Shin, Hyeon Jeong; Lee, Ji Hye; Kim, Yong Duk; Shin, Injae; Sim, Taebo; Lim, Dong-Kwon

Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14

合成一系列4-氨基-1H-吡唑类化合物及其作为CDK14共价抑制剂的构效关系

Ferguson, Fleur M; Doctor, Zainab M; Ficarro, Scott B; Marto, Jarrod A; Kim, Nam Doo; Sim, Taebo; Gray, Nathanael S

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains

嘧啶并苯并二嗪酮作为激酶和溴结构域抑制剂的选择性受结构和阻转异构体因素的影响

Wang, Jinhua; Erazo, Tatiana; Ferguson, Fleur M; Buckley, Dennis L; Gomez, Nestor; Muñoz-Guardiola, Pau; Diéguez-Martínez, Nora; Deng, Xianming; Hao, Mingfeng; Massefski, Walter; Fedorov, Oleg; Offei-Addo, Nana Kwaku; Park, Paul M; Dai, Lingling; DiBona, Amy; Becht, Kelly; Kim, Nam Doo; McKeown, Michael R; Roberts, Justin M; Zhang, Jinwei; Sim, Taebo; Alessi, Dario R; Bradner, James E; Lizcano, Jose M; Blacklow, Stephen C; Qi, Jun; Xu, Xiang; Gray, Nathanael S

Identification of Existing Drugs That Effectively Target NTRK1 and ROS1 Rearrangements in Lung Cancer

识别能够有效靶向肺癌中 NTRK1 和 ROS1 重排的现有药物

Chong, Curtis R; Bahcall, Magda; Capelletti, Marzia; Kosaka, Takayuki; Ercan, Dalia; Sim, Taebo; Sholl, Lynette M; Nishino, Mizuki; Johnson, Bruce E; Gray, Nathanael S; Jänne, Pasi A