日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Screening of a kinase inhibitor library identified novel targetable kinase pathways in triple-negative breast cancer

激酶抑制剂库的筛选确定了三阴性乳腺癌中新的可靶向激酶通路

Caroline H Rinderle, Christopher V Baker, Courtney B Lagarde, Khoa Nguyen, Sara Al-Ghadban, Margarite D Matossian, Van T Hoang, Elizabeth C Martin, Bridgette M Collins-Burow, Simak Ali, David H Drewry, Matthew E Burow, Bruce A Bunnell

High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design

人类 CDK 活化激酶的高分辨率低温电子显微镜可用于基于结构的药物设计

Victoria I Cushing, Adrian F Koh, Junjie Feng, Kaste Jurgaityte, Alexander Bondke, Sebastian H B Kroll, Marion Barbazanges, Bodo Scheiper, Ash K Bahl, Anthony G M Barrett, Simak Ali, Abhay Kotecha, Basil J Greber

Selective inhibition of CDK9 in triple negative breast cancer

在三阴性乳腺癌中选择性抑制CDK9

Ebtihal H Mustafa, Geraldine Laven-Law, Zoya Kikhtyak, Van Nguyen, Simak Ali, Alex A Pace, Richard Iggo, Alemwork Kebede, Ben Noll, Shudong Wang, Jean M Winter, Amy R Dwyer, Wayne D Tilley, Theresa E Hickey

Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling

蛋白质组学分析显示 ESR1 突变增强细胞周期蛋白依赖性激酶信号传导

Tommaso De Marchi, Chun-Fui Lai, Georgia M Simmons, Isabella Goldsbrough, Alison Harrod, Thai Lam, Lakjaya Buluwela, Sven Kjellström, Christian Brueffer, Lao H Saal, Johan Malmström, Simak Ali, Emma Niméus

Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

活跃的生长信号促进衰老和癌细胞对 CDK7 抑制的敏感性

Gemma A Wilson, Karla Vuina, Georgina Sava, Caroline Huard, Leticia Meneguello, Jasmin Coulombe-Huntington, Thierry Bertomeu, Rory J Maizels, Josh Lauring, Janos Kriston-Vizi, Mike Tyers, Simak Ali, Cosetta Bertoli, Robertus A M de Bruin

The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer

CDK7 抑制剂 CT7001 (Samuraciclib) 靶向增殖途径以抑制晚期前列腺癌

Theodora A Constantin, Anabel Varela-Carver, Kyle K Greenland, Gilberto Serrano de Almeida, Ellen Olden, Lucy Penfold, Simon Ang, Alice Ormrod, Damien A Leach, Chun-Fui Lai, Edward K Ainscow, Ash K Bahl, David Carling, Matthew J Fuchter, Simak Ali, Charlotte L Bevan

The CDK4/6 Inhibitor Palbociclib Inhibits Estrogen-Positive and Triple Negative Breast Cancer Bone Metastasis In Vivo

CDK4/6 抑制剂 Palbociclib 可在体内抑制雌激素阳性和三阴性乳腺癌骨转移

Lubaid Saleh, Penelope D Ottewell, Janet E Brown, Steve L Wood, Nichola J Brown, Caroline Wilson, Catherine Park, Simak Ali, Ingunn Holen

Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence

上皮-间质可塑性决定雌激素受体阳性乳腺癌休眠和上皮再转化驱动复发

Patrick Aouad, Yueyun Zhang, Fabio De Martino, Céline Stibolt, Simak Ali, Giovanna Ambrosini, Sendurai A Mani, Kelly Maggs, Hazel M Quinn, George Sflomos, Cathrin Brisken

ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

ESR1 突变乳腺癌表现出基底细胞角蛋白升高和免疫激活

Zheqi Li, Olivia McGinn, Yang Wu, Amir Bahreini, Nolan M Priedigkeit, Kai Ding, Sayali Onkar, Caleb Lampenfeld, Carol A Sartorius, Lori Miller, Margaret Rosenzweig, Ofir Cohen, Nikhil Wagle, Jennifer K Richer, William J Muller, Laki Buluwela, Simak Ali, Tullia C Bruno, Dario A A Vignali, Yusi Fang, 

Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis

热点 ESR1 突变是乳腺癌转移的多模式和情境调节因子

Zheqi Li, Yang Wu, Megan E Yates, Nilgun Tasdemir, Amir Bahreini, Jian Chen, Kevin M Levine, Nolan M Priedigkeit, Azadeh Nasrazadani, Simak Ali, Laki Buluwela, Spencer Arnesen, Jason Gertz, Jennifer K Richer, Benjamin Troness, Dorraya El-Ashry, Qiang Zhang, Lorenzo Gerratana, Youbin Zhang, Massimo C