日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors

SHOC2-KRAS-PP1C复合物的结构揭示了RAS亚型特异性决定因素,并为RAS抑制剂靶向复合物组装提供了新的见解。

Daniel A Bonsor #,Lorenzo I Finci #,Jacob R Potter,Lucy C Young,Vanessa E Wall,Ruby Goldstein de Salazar,Katie R Geis,Tyler Stephens,Joseph Finney,Dwight V Nissley,Frank McCormick,Dhirendra K Simanshu

KRAS4a and KRAS4b show distinct lipid-dependent regulation of RAS-RAF membrane dynamics

KRAS4a 和 KRAS4b 对 RAS-RAF 膜动力学表现出不同的脂质依赖性调控作用

Georgouli, Konstantia; Tempkin, Jeremy O B; Stanton, Liam G; Oppelstrup, Tomas; Shrestha, Rebika; Carpenter, Timothy S; Aydin, Fikret; Zhang, Xiaohua; Bhatia, Harsh; Yang, Yue; Van, Que N; Bonilla, Pedro Andrade; Gulten, Gulcin; Goswami, Debanjan; Di Natale, Francesco; Chavez, Joseph R; Moon, Joseph Y; Dharuman, Gautham; Hengartner, Nicolas W; Simanshu, Dhirendra K; Tran, Timothy H; Nguyen, Kien; Stanley, Christopher B; Van Essen, Brian; Bremer, Peer-Timo; Lightstone, Felice C; Stephen, Andrew G; Glosli, James N; Gnanakaran, Sandrasegaram; Turbyville, Thomas J; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H; Ingólfsson, Helgi I

Structural basis for LZTR1 recognition of RAS GTPases for degradation

LZTR1识别RAS GTP酶并进行降解的结构基础

Dharmaiah, Srisathiyanarayanan; Bonsor, Daniel A; Mo, Stephanie P; Fernandez-Cabrera, Alvaro; Chan, Albert H; Messing, Simon; Drew, Matthew; Vega, Martha; Nissley, Dwight V; Esposito, Dominic; Castel, Pau; Simanshu, Dhirendra K

Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.

发现 BBO-8520,一种首创的直接共价双重抑制剂,可抑制 GTP 结合 (ON) 和 GDP 结合 (OFF) 的 KRASG12C

Maciag Anna E, Stice James P, Wang Bin, Sharma Alok K, Chan Albert H, Lin Ken, Singh Devansh, Dyba Marcin, Yang Yue, Setoodeh Saman, Smith Brian P, Ju Jin Hyun, Jeknic Stevan, Rabara Dana, Zhang Zuhui, Larsen Erik K, Esposito Dominic, Denson John-Paul, Ranieri Michela, Meynardie Mary, Mehdizadeh Sadaf, Alexander Patrick A, Abreu Blanco Maria, Turner David M, Xu Rui, Lightstone Felice C, Wong Kwok-Kin, Stephen Andrew G, Wang Keshi, Simanshu Dhirendra K, Sinkevicius Kerstin W, Nissley Dwight V, Wallace Eli, McCormick Frank, Beltran Pedro J

Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation.

从结构角度深入了解 RAS-PI3Kα 同工型特异性相互作用以及 RAS 在 PI3Kα 激活中的作用

Czyzyk Daniel, Yan Wupeng, Messing Simon, Gillette William, Tsuji Takashi, Yamaguchi Mitsuhiro, Furuzono Shinji, Turner David M, Esposito Dominic, Nissley Dwight V, McCormick Frank, Simanshu Dhirendra K

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

通过对 CaaX 盒半胱氨酸进行直接共价攻击,阻断 KRAS4b 的 C 端加工

Maciag Anna E, Yang Yue, Sharma Alok K, Turner David M, DeHart Caroline J, Abdelkarim Hazem, Fan Lixin, Smith Brian P, Kumari Vandana, Dyba Marcin, Rigby Megan, Castillo Badillo Jean A, Adams Lauren, Fornelli Luca, Fox Stephen, Brafman Alla, Turbyville Thomas, Gillette William, Messing Simon, Agamasu Constance, Wolfe Andrew L, Gysin Stephan, Chan Albert H, Simanshu Dhirendra K, Esposito Dominic, Chertov Oleg, Stephen Andrew G, Arkin Michelle, Renslo Adam, Kelleher Neil L, Gaponenko Vadim, Lightstone Felice C, Nissley Dwight V, McCormick Frank

Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints

对KRAS开关II口袋抑制剂的生物物理和结构分析揭示了等位基因特异性结合限制。

Alexander, Patrick; Chan, Albert H; Rabara, Dana; Swain, Monalisa; Larsen, Erik K; Dyba, Marcin; Chertov, Oleg; Ashraf, Mariam; Champagne, Allison; Lin, Ken; Maciag, Anna; Gillette, William K; Nissley, Dwight V; McCormick, Frank; Simanshu, Dhirendra K; Stephen, Andrew G

Functional and structural insights into RAS effector proteins

RAS效应蛋白的功能和结构研究

Mozzarelli, Alessandro M; Simanshu, Dhirendra K; Castel, Pau

Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties

KRAS4a 和 KRAS4b 剪接变体的比较分析揭示了它们独特的结构和功能特性。

Matthew J Whitley ,Timothy H Tran ,Megan Rigby ,Ming Yi ,Srisathiyanarayanan Dharmaiah ,Timothy J Waybright ,Nitya Ramakrishnan ,Shelley Perkins ,Troy Taylor ,Simon Messing ,Dominic Esposito ,Dwight V Nissley ,Frank McCormick ,Andrew G Stephen ,Thomas Turbyville ,Gabriel Cornilescu ,Dhirendra K Simanshu

RAS and SHOC2 Roles in RAF Activation and Therapeutic Considerations

RAS 和 SHOC2 在 RAF 激活中的作用及治疗考量

Bonsor, Daniel A; Simanshu, Dhirendra K