日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An Acetylcholine M1 Receptor-Positive Allosteric Modulator (TAK-071) in Parkinson Disease With Cognitive Impairment: A Phase 2 Randomized Clinical Trial

乙酰胆碱M1受体正向变构调节剂(TAK-071)治疗伴有认知障碍的帕金森病:一项II期随机临床试验

Shanbhag, Niraj M; Padmanabhan, Jaya L; Zhang, Zheng; Harel, Brian T; Jia, Hongxia; Kangarloo, Tairmae; Yin, Wei; Dowling, Ariel V; Laurenza, Antonio; Khudyakov, Polyna; Galinsky, Kevin; Latzman, Robert D; Simuni, Tanya; Weintraub, Daniel; Horak, Fay B; Lustig, Cindy; Maruff, Paul; Simen, Arthur A

Phase 1, randomized trials of MEDI1341: cerebrospinal fluid free α-synuclein lowered by >50

MEDI1341 的 1 期随机试验:脑脊液游离 α-突触核蛋白降低 >50

Shering, Craig; Pomfret, Michael; Kubiak, Robert J; Pouliquen, Isabelle J; Yin, Wei; Simen, Arthur; Ratti, Elena; Hussain, Zubair; Perkinton, Michael; Tan, Keith; Scott, Kirsten M; Ostenfeld, Thor; Chessell, Iain

Population Pharmacokinetic and Exposure-Response Analysis of the Cognitive Effects of TAK-071 in Participants With Parkinson Disease and Cognitive Impairment

帕金森病伴认知障碍患者服用TAK-071的群体药代动力学和暴露-反应分析

Jia, Hongxia; Facius, Axel; Jennings, Rachel; Hang, Yaming; Padmanabhan, Jaya; Shanbhag, Niraj M; Harel, Brian T; Simen, Arthur; Yin, Wei

Investigation of genetic determinants of cognitive change in later life

对晚年认知变化遗传决定因素的研究

Mahedy, Liam; Anderson, Emma L; Tilling, Kate; Thornton, Zak A; Elmore, Andrew R; Szalma, Sándor; Simen, Arthur; Culp, Meredith; Zicha, Stephen; Harel, Brian T; Davey Smith, George; Smith, Erin N; Paternoster, Lavinia

Safety, pharmacokinetics and quantitative EEG modulation of TAK-071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects

在健康受试者中,新型毒蕈碱M1受体正向变构调节剂TAK-071的安全性、药代动力学和定量脑电图调节作用

Yin, Wei; Mamashli, Fahimeh; Buhl, Derek L; Khudyakov, Polyna; Volfson, Dmitri; Martenyi, Ferenc; Gevorkyan, Hakop; Rosen, Laura; Simen, Arthur A

The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect

压力、神经可塑性和脑回路相关基因在抑郁表型中的作用:小鼠忽视模型中的趋同性发现

Montalvo-Ortiz, Janitza L; Bordner, Kelly A; Carlyle, Becky C; Gelernter, Joel; Simen, Arthur A; Kaufman, Joan

A randomized, crossover, placebo-controlled clinical trial to assess the sensitivity of the CRCDS Mini-Sim to the next-day residual effects of zopiclone

一项随机、交叉、安慰剂对照临床试验,旨在评估 CRCDS Mini-Sim 对佐匹克隆次日残留效应的敏感性

Simen, Arthur A; Gargano, Cynthia; Cha, Jang-Ho; Drexel, Melissa; Bautmans, An; Heirman, Ingeborg; Laethem, Tine; Hochadel, Thomas; Gheyle, Lien; Bleys, Kim; Beals, Chan; Stoch, Aubrey; Kay, Gary G; Struyk, Arie

Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry

儿童虐待、抑郁症以及与压力、神经可塑性和大脑回路相关的基因甲基化

Weder, Natalie; Zhang, Huiping; Jensen, Kevin; Yang, Bao Zhu; Simen, Arthur; Jackowski, Andrea; Lipschitz, Deborah; Douglas-Palumberi, Heather; Ge, Margrat; Perepletchikova, Francheska; O'Loughlin, Kerry; Hudziak, James J; Gelernter, Joel; Kaufman, Joan

cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

cAMP-PKA对tau蛋白的磷酸化会增加衰老联合皮层退化的风险

Carlyle, Becky C; Nairn, Angus C; Wang, Min; Yang, Yang; Jin, Lu E; Simen, Arthur A; Ramos, Brian P; Bordner, Kelly A; Craft, George E; Davies, Peter; Pletikos, Mihovil; Šestan, Nenad; Arnsten, Amy F T; Paspalas, Constantinos D

Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects

抑郁症患者死后海马体中突触和谷氨酸相关基因表达改变

Duric, Vanja; Banasr, Mounira; Stockmeier, Craig A; Simen, Arthur A; Newton, Samuel S; Overholser, James C; Jurjus, George J; Dieter, Lesa; Duman, Ronald S