日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery

利用细胞色素P450人源化小鼠模型改进血吸虫病药物研发

Davey, Sarah D; Forde-Thomas, Josephine E; Hulme, Benjamin J; Lees, Kristin; Costain, Alice H; Evans, Mary; Rinaldi, Gabriel; Frame, Laura; Stojanovski, Laste; Simeons, Frederick R C; Tavendale, Amy; MacLeod, A Kenneth; Pichon, Remi; Lee, Yi-Hsuan; Polak, Oktawia; Chalmers, Iain W; Dankwa, Bismark; Odhiambo, Brenda Kisia; Guimaraes, Victor Hugo; Hegarty, Matthew; Swain, Martin T; Aubrey, Wayne; Caldwell, Nicola; MacDonald, Andrew S; Gilbert, Ian H; Baragaña, Beatriz; Read, Kevin D; Hoffmann, Karl F

Humanization of Drug Metabolism in the Plasmodium berghei Mouse Model for Antimalarial Drug Discovery

利用伯氏疟原虫小鼠模型进行药物代谢人源化研究以开发抗疟药物

MacLeod, A Kenneth; Merino, Cristina; Viera-Morilla, Sara; Frame, Laura; Tavendale, Amy; Duncan, Christina; Ferguson, Liam; Pinto, Erika G; Simeons, Frederick R C; Gomez-Jimenez, Vanessa; García, Ana Belén; Riley, Jennifer; Shishikura, Yoko; Martínez-Martínez, María Santos; Wolf, C Roland; Read, Kevin D

Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens.

合理探索 2,4-二氨基嘧啶作为 DHFR 抑制剂对脓肿分枝杆菌和鸟分枝杆菌(两种新兴人类病原体)的活性

Andrade Meirelles Matheus, Almeida Vitor M, Sullivan Jaryd R, de Toledo Ian, Dos Reis Caio Vinicius, Cunha Micael Rodrigues, Zigweid Rachel, Shim Abraham, Sankaran Banumathi, Woodward Elijah L, Seibold Steve, Liu Lijun, Mian Mohammad Rasel, Battaile Kevin P, Riley Jennifer, Duncan Christina, Simeons Frederick R C, Ferguson Liam, Joji Halimatu, Read Kevin D, Lovell Scott, Staker Bart L, Behr Marcel A, Pilli Ronaldo A, Couñago Rafael M

Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism

利用人性化药物代谢模型加速传染病药物的发现和开发

A Kenneth MacLeod, Kevin-Sebastien Coquelin, Leticia Huertas, Frederick R C Simeons, Jennifer Riley, Patricia Casado, Laura Guijarro, Ruth Casanueva, Laura Frame, Erika G Pinto, Liam Ferguson, Christina Duncan, Nicole Mutter, Yoko Shishikura, Colin J Henderson, David Cebrian, C Roland Wolf, Kevin D

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues

2,4-二氨基噻唑系列药物的开发用于治疗非洲人类锥虫病,凸显了类似物静态杀灭筛选的重要性

Laura A T Cleghorn, Richard J Wall, Sébastien Albrecht, Stuart A MacGowan, Suzanne Norval, Manu De Rycker, Andrew Woodland, Daniel Spinks, Stephen Thompson, Stephen Patterson, Victoriano Corpas Lopez, Gourav Dey, Iain T Collie, Irene Hallyburton, Robert Kime, Frederick R C Simeons, Laste Stojanovski

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

重新定位二氨基噻唑系列化合物,证实其靶向细胞周期蛋白依赖性激酶CRK12,可用于治疗非洲动物锥虫病

Smith, Alasdair; Wall, Richard J; Patterson, Stephen; Rowan, Tim; Rico Vidal, Eva; Stojanovski, Laste; Huggett, Margaret; Hampton, Shahienaz E; Thomas, Michael G; Corpas Lopez, Victoriano; Gillingwater, Kirsten; Duke, Jeff; Napier, Grant; Peter, Rose; Vitouley, Hervé S; Harrison, Justin R; Milne, Rachel; Jeacock, Laura; Baker, Nicola; Davis, Susan H; Simeons, Frederick; Riley, Jennifer; Horn, David; Brun, Reto; Zuccotto, Fabio; Witty, Michael J; Wyllie, Susan; Read, Kevin D; Gilbert, Ian H

Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease

鉴定和开发一系列二取代哌嗪类化合物用于治疗恰加斯病

McGonagle, Kate; Tarver, Gary J; Cantizani, Juan; Cotillo, Ignacio; Dodd, Peter G; Ferguson, Liam; Gilbert, Ian H; Marco, Maria; Miles, Tim; Naylor, Claire; Osuna-Cabello, Maria; Paterson, Christy; Read, Kevin D; Pinto, Erika G; Riley, Jennifer; Scullion, Paul; Shishikura, Yoko; Simeons, Frederick; Stojanovski, Laste; Svensen, Nina; Thomas, John; Wyatt, Paul G; Manzano, Pilar; De Rycker, Manu; Thomas, Michael G

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

基于一系列蛋白酶体抑制剂的支架跃迁策略,我们获得了一种用于治疗内脏利什曼病的临床前候选药物。

Thomas, Michael; Brand, Stephen; De Rycker, Manu; Zuccotto, Fabio; Lukac, Iva; Dodd, Peter G; Ko, Eun-Jung; Manthri, Sujatha; McGonagle, Kate; Osuna-Cabello, Maria; Riley, Jennifer; Pont, Caterina; Simeons, Frederick; Stojanovski, Laste; Thomas, John; Thompson, Stephen; Viayna, Elisabet; Fiandor, Jose M; Martin, Julio; Wyatt, Paul G; Miles, Timothy J; Read, Kevin D; Marco, Maria; Gilbert, Ian H

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

发现和优化 5-氨基-1,2,3-三唑-4-甲酰胺系列化合物对抗克氏锥虫

Brand, Stephen; Ko, Eun Jung; Viayna, Elisabet; Thompson, Stephen; Spinks, Daniel; Thomas, Michael; Sandberg, Lars; Francisco, Amanda F; Jayawardhana, Shiromani; Smith, Victoria C; Jansen, Chimed; De Rycker, Manu; Thomas, John; MacLean, Lorna; Osuna-Cabello, Maria; Riley, Jennifer; Scullion, Paul; Stojanovski, Laste; Simeons, Frederick R C; Epemolu, Ola; Shishikura, Yoko; Crouch, Sabrinia D; Bakshi, Tania S; Nixon, Christopher J; Reid, Iain H; Hill, Alan P; Underwood, Tim Z; Hindley, Sean J; Robinson, Sharon A; Kelly, John M; Fiandor, Jose M; Wyatt, Paul G; Marco, Maria; Miles, Timothy J; Read, Kevin D; Gilbert, Ian H

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

甲硫氨酰-tRNA 合成酶作为杜氏利什曼原虫可用药靶点的化学验证

Leah S Torrie, Stephen Brand, David A Robinson, Eun Jung Ko, Laste Stojanovski, Frederick R C Simeons, Susan Wyllie, John Thomas, Lucy Ellis, Maria Osuna-Cabello, Ola Epemolu, Andrea Nühs, Jennifer Riley, Lorna MacLean, Sujatha Manthri, Kevin D Read, Ian H Gilbert, Alan H Fairlamb, Manu De Rycker