日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery

利用细胞色素P450人源化小鼠模型改进血吸虫病药物研发

Davey, Sarah D; Forde-Thomas, Josephine E; Hulme, Benjamin J; Lees, Kristin; Costain, Alice H; Evans, Mary; Rinaldi, Gabriel; Frame, Laura; Stojanovski, Laste; Simeons, Frederick R C; Tavendale, Amy; MacLeod, A Kenneth; Pichon, Remi; Lee, Yi-Hsuan; Polak, Oktawia; Chalmers, Iain W; Dankwa, Bismark; Odhiambo, Brenda Kisia; Guimaraes, Victor Hugo; Hegarty, Matthew; Swain, Martin T; Aubrey, Wayne; Caldwell, Nicola; MacDonald, Andrew S; Gilbert, Ian H; Baragaña, Beatriz; Read, Kevin D; Hoffmann, Karl F

Humanization of Drug Metabolism in the Plasmodium berghei Mouse Model for Antimalarial Drug Discovery

利用伯氏疟原虫小鼠模型进行药物代谢人源化研究以开发抗疟药物

MacLeod, A Kenneth; Merino, Cristina; Viera-Morilla, Sara; Frame, Laura; Tavendale, Amy; Duncan, Christina; Ferguson, Liam; Pinto, Erika G; Simeons, Frederick R C; Gomez-Jimenez, Vanessa; García, Ana Belén; Riley, Jennifer; Shishikura, Yoko; Martínez-Martínez, María Santos; Wolf, C Roland; Read, Kevin D

Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens.

合理探索 2,4-二氨基嘧啶作为 DHFR 抑制剂对脓肿分枝杆菌和鸟分枝杆菌(两种新兴人类病原体)的活性

Andrade Meirelles Matheus, Almeida Vitor M, Sullivan Jaryd R, de Toledo Ian, Dos Reis Caio Vinicius, Cunha Micael Rodrigues, Zigweid Rachel, Shim Abraham, Sankaran Banumathi, Woodward Elijah L, Seibold Steve, Liu Lijun, Mian Mohammad Rasel, Battaile Kevin P, Riley Jennifer, Duncan Christina, Simeons Frederick R C, Ferguson Liam, Joji Halimatu, Read Kevin D, Lovell Scott, Staker Bart L, Behr Marcel A, Pilli Ronaldo A, Couñago Rafael M

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

发现和优化 5-氨基-1,2,3-三唑-4-甲酰胺系列化合物对抗克氏锥虫

Brand, Stephen; Ko, Eun Jung; Viayna, Elisabet; Thompson, Stephen; Spinks, Daniel; Thomas, Michael; Sandberg, Lars; Francisco, Amanda F; Jayawardhana, Shiromani; Smith, Victoria C; Jansen, Chimed; De Rycker, Manu; Thomas, John; MacLean, Lorna; Osuna-Cabello, Maria; Riley, Jennifer; Scullion, Paul; Stojanovski, Laste; Simeons, Frederick R C; Epemolu, Ola; Shishikura, Yoko; Crouch, Sabrinia D; Bakshi, Tania S; Nixon, Christopher J; Reid, Iain H; Hill, Alan P; Underwood, Tim Z; Hindley, Sean J; Robinson, Sharon A; Kelly, John M; Fiandor, Jose M; Wyatt, Paul G; Marco, Maria; Miles, Timothy J; Read, Kevin D; Gilbert, Ian H

Automated design of ligands to polypharmacological profiles

配体自动化设计及其多药理学特性

Besnard, Jérémy; Ruda, Gian Filippo; Setola, Vincent; Abecassis, Keren; Rodriguiz, Ramona M; Huang, Xi-Ping; Norval, Suzanne; Sassano, Maria F; Shin, Antony I; Webster, Lauren A; Simeons, Frederick R C; Stojanovski, Laste; Prat, Annik; Seidah, Nabil G; Constam, Daniel B; Bickerton, G Richard; Read, Kevin D; Wetsel, William C; Gilbert, Ian H; Roth, Bryan L; Hopkins, Andrew L

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis

抗锥虫药物非西硝唑显示出治疗内脏利什曼病的潜力。

Wyllie, Susan; Patterson, Stephen; Stojanovski, Laste; Simeons, Frederick R C; Norval, Suzanne; Kime, Robert; Read, Kevin D; Fairlamb, Alan H