日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small molecule modulation of p75(NTR) engages the autophagy-lysosomal pathway and reduces huntingtin aggregates in cellular and mouse models of Huntington's disease.

小分子调节 p75(NTR) 可激活自噬-溶酶体途径,并减少亨廷顿病细胞和小鼠模型中的亨廷顿蛋白聚集体

Simmons Danielle A, Alexander Namitha, Cao Gloria, Rippin Ido, Lugassy Yarine, Eldar-Finkelman Hagit, Longo Frank M

Twenty years of therapeutic development in tauopathy mouse models: a scoping review

二十年来tau蛋白病小鼠模型治疗进展:一项范围综述

Langness, Vanessa F; Simmons, Danielle A; McHugh, Tyne L M; Butler, Robert R 3rd; Zhou, James; Liu, Harry; Yang, Tao; Ellerby, Lisa M; Longo, Frank M

HGG-21. Oncogenic tyrosine kinase gene fusions in infant-type hemispheric gliomas - comparison of RNA- and DNA-based methods for their reliable detection

HGG-21. 婴儿型半球胶质瘤中致癌酪氨酸激酶基因融合——基于RNA和DNA的可靠检测方法的比较

Simmons, Danielle A; Belichenko, Nadia P; Yang, Tao; Condon, Christina; Monbureau, Marie; Shamloo, Mehrdad; Jing, Deqiang; Massa, Stephen M; Longo, Frank M; Pietsch, Torsten; Gielen, Gerrit; Waha, Andreas; Doerner, Evelyn; von Bueren, Andre O; Vokuhl, Christian; Kristiansen, Glen; Kramm, Christof

Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease

调节神经营养因子受体信号传导作为亨廷顿病的一种治疗策略

Simmons, Danielle A

A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice

小分子p75NTR配体可使信号传导正常化,并减轻R6/2和BACHD小鼠的亨廷顿病表型。

Simmons, Danielle A; Belichenko, Nadia P; Ford, Ellen C; Semaan, Sarah; Monbureau, Marie; Aiyaswamy, Sruti; Holman, Cameron M; Condon, Christina; Shamloo, Mehrdad; Massa, Stephen M; Longo, Frank M

A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression

小分子p75NTR配体LM11A-31可逆转阿尔茨海默病小鼠模型中处于中晚期疾病进展阶段的胆碱能神经突营养不良。

Simmons, Danielle A; Knowles, Juliet K; Belichenko, Nadia P; Banerjee, Gargi; Finkle, Carly; Massa, Stephen M; Longo, Frank M

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model

小分子p75NTR配体可预防阿尔茨海默病小鼠模型中的认知缺陷和神经突退化

Knowles, Juliet K; Simmons, Danielle A; Nguyen, Thuy-Vi V; Vander Griend, Lilith; Xie, Youmei; Zhang, Hong; Yang, Tao; Pollak, Julia; Chang, Timothy; Arancio, Ottavio; Buckwalter, Marion S; Wyss-Coray, Tony; Massa, Stephen M; Longo, Frank M

BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats

BDNF上调可挽救中年卵巢切除大鼠的突触可塑性

Kramár, Enikö A; Chen, Lulu Y; Lauterborn, Julie C; Simmons, Danielle A; Gall, Christine M; Lynch, Gary

Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice

短期安帕卡因治疗可延缓R6/2小鼠亨廷顿病表型的进展。

Simmons, Danielle A; Mehta, Rishi A; Lauterborn, Julie C; Gall, Christine M; Lynch, Gary

Nitric oxidergic cells related to ejaculation in gerbil forebrain contain androgen receptor and respond to testosterone

沙鼠前脑中与射精相关的氧化氮能细胞含有雄激素受体,并对睾酮有反应。

Simmons, Danielle A; Yahr, Pauline