日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Gonadal sex reversal at single-cell resolution in Znrf3-deficient mice

Znrf3缺陷小鼠的性腺性别逆转以单细胞分辨率呈现

Kay, Raissa G G; Reeves, Richard; Siggers, Pam; Greenaway, Simon; Mallon, Ann-Marie; Wells, Sara; Koo, Bon-Kyoung; Mayère, Chloé; Nef, Serge; Greenfield, Andy; Simon, Michelle M

Genic constraint against nonsynonymous variation across the mouse genome

小鼠基因组中针对非同义变异的基因约束

Powell, George; Simon, Michelle M; Pulit, Sara; Mallon, Ann-Marie; Lindgren, Cecilia M

Making sense of the linear genome, gene function and TADs

理解线性基因组、基因功能和TAD

Long, Helen S; Greenaway, Simon; Powell, George; Mallon, Ann-Marie; Lindgren, Cecilia M; Simon, Michelle M

Modelling the genetic aetiology of complex disease: human-mouse conservation of noncoding features and disease-associated loci

复杂疾病遗传病因学建模:人类与小鼠非编码特征和疾病相关基因位点的保守性

Powell, George; Long, Helen; Zolkiewski, Louisa; Dumbell, Rebecca; Mallon, Ann-Marie; Lindgren, Cecilia M; Simon, Michelle M

Mouse genomic and cellular annotations

小鼠基因组和细胞注释

Long, Helen; Reeves, Richard; Simon, Michelle M

A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease

对小鼠增强子结构的整体分析揭示了类似的多种效应以及与人类疾病的相关性。

Sethi, Siddharth; Vorontsov, Ilya E; Kulakovskiy, Ivan V; Greenaway, Simon; Williams, John; Makeev, Vsevolod J; Brown, Steve D M; Simon, Michelle M; Mallon, Ann-Marie

An N-Ethyl-N-Nitrosourea (ENU)-Induced Tyr265Stop Mutation of the DNA Polymerase Accessory Subunit Gamma 2 (Polg2) Is Associated With Renal Calcification in Mice

N-乙基-N-亚硝基脲(ENU)诱导的DNA聚合酶辅助亚基γ2(Polg2)Tyr265终止突变与小鼠肾脏钙化相关

Gorvin, Caroline M; Ahmad, Bushra N; Stechman, Michael J; Loh, Nellie Y; Hough, Tertius A; Leo, Paul; Marshall, Mhairi; Sethi, Siddharth; Bentley, Liz; Piret, Sian E; Reed, Anita; Jeyabalan, Jeshmi; Christie, Paul T; Wells, Sara; Simon, Michelle M; Mallon, Ann-Marie; Schulz, Herbert; Huebner, Norbert; Brown, Matthew A; Cox, Roger D; Brown, Steve D; Thakker, Rajesh V

An N-Ethyl-N-Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion

N-乙基-N-亚硝基脲(ENU)诱变小鼠模型用于研究由椎体融合引起的常染色体显性非综合征性脊柱侧弯

Esapa, Christopher T; Piret, Sian E; Nesbit, M Andrew; Thomas, Gethin P; Coulton, Leslie A; Gallagher, Orla M; Simon, Michelle M; Kumar, Saumya; Mallon, Ann-Marie; Bellantuono, Ilaria; Brown, Matthew A; Croucher, Peter I; Potter, Paul K; Brown, Steve Dm; Cox, Roger D; Thakker, Rajesh V

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

一项大规模听力损失筛查揭示了听觉功能障碍方面广泛且尚未被探索的遗传图谱。

Bowl, Michael R; Simon, Michelle M; Ingham, Neil J; Greenaway, Simon; Santos, Luis; Cater, Heather; Taylor, Sarah; Mason, Jeremy; Kurbatova, Natalja; Pearson, Selina; Bower, Lynette R; Clary, Dave A; Meziane, Hamid; Reilly, Patrick; Minowa, Osamu; Kelsey, Lois; Tocchini-Valentini, Glauco P; Gao, Xiang; Bradley, Allan; Skarnes, William C; Moore, Mark; Beaudet, Arthur L; Justice, Monica J; Seavitt, John; Dickinson, Mary E; Wurst, Wolfgang; de Angelis, Martin Hrabe; Herault, Yann; Wakana, Shigeharu; Nutter, Lauryl M J; Flenniken, Ann M; McKerlie, Colin; Murray, Stephen A; Svenson, Karen L; Braun, Robert E; West, David B; Lloyd, K C Kent; Adams, David J; White, Jacqui; Karp, Natasha; Flicek, Paul; Smedley, Damian; Meehan, Terrence F; Parkinson, Helen E; Teboul, Lydia M; Wells, Sara; Steel, Karen P; Mallon, Ann-Marie; Brown, Steve D M

A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.

Nischarin 基因突变通过 LIMK1 和 NF-κB 通路引起中耳炎

Crompton Michael, Purnell Tom, Tyrer Hayley E, Parker Andrew, Ball Greg, Hardisty-Hughes Rachel E, Gale Richard, Williams Debbie, Dean Charlotte H, Simon Michelle M, Mallon Ann-Marie, Wells Sara, Bhutta Mahmood F, Burton Martin J, Tateossian Hilda, Brown Steve D M