Simon Cocklin相关文献与解析，生知库 | 链接生命科学的每一步

Emily M Esquea, Lorela Ciraku, Riley G Young, Jessica Merzy, Alexandra N Talarico, Nusaiba N Ahmed, Mangalam Karuppiah, Anna Ramesh, Adam Chatoff, Claudia V Crispim, Adel A Rashad, Simon Cocklin, Nathaniel W Snyder, Joris Beld, Nicole L Simone, Mauricio J Reginato, Alexej Dick

免疫

细胞生物学

乳腺癌

肿瘤细胞

发表日期：2024

文献求助收藏

Copper Modulates the Catalytic Activity of Protein Kinase CK2

铜调节蛋白激酶 CK2 的催化活性

期刊:Frontiers in Molecular Biosciences

影响因子:3.9

doi:10.3389/fmolb.2022.878652

John E Chojnowski, Rongrong Li, Tiffany Tsang, Fatimah H Alfaran, Alexej Dick, Simon Cocklin, Donita C Brady, Todd I Strochlic

信号转导

发表日期：2022

文献求助收藏

Rapid Optimization of the Metabolic Stability of a Human Immunodeficiency Virus Type-1 Capsid Inhibitor Using a Multistep Computational Workflow

使用多步计算工作流程快速优化人类免疫缺陷病毒 1 型衣壳抑制剂的代谢稳定性

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.0c01810

Megan E Meuser, Poli Adi Narayana Reddy, Alexej Dick, Jean Marc Maurancy, Joseph M Salvino, Simon Cocklin

Alprazolam Prompts HIV-1 Transcriptional Reactivation and Enhances CTL Response Through RUNX1 Inhibition and STAT5 Activation

阿普唑仑通过抑制 RUNX1 和激活 STAT5 促进 HIV-1 转录再激活并增强 CTL 反应

期刊:Frontiers in Neurology

影响因子:2.7

doi:10.3389/fneur.2021.663793

Angel Lin, Weam Othman Elbezanti, Alexis Schirling, Adel Ahmed, Rachel Van Duyne, Simon Cocklin, Zachary Klase

New RAD51 Inhibitors to Target Homologous Recombination in Human Cells

新型 RAD51 抑制剂靶向人类细胞中的同源重组

期刊:Genes

影响因子:

doi:10.3390/genes12060920

Irina S Shkundina, Alexander A Gall, Alexej Dick, Simon Cocklin, Alexander V Mazin

Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities

含苯磺酰胺的苯丙氨酸衍生物作为新型HIV-1衣壳抑制剂的设计、合成及机理研究及其抗病毒活性的提高

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.0c00015

Lin Sun, Alexej Dick, Megan E Meuser, Tianguang Huang, Waleed A Zalloum, Chin-Ho Chen, Srinivasulu Cherukupalli, Shujing Xu, Xiao Ding, Ping Gao, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Simon Cocklin, Kuo-Hsiung Lee, Xinyong Liu, Peng Zhan

Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities

4-苯基-1H-1,2,3-三唑苯丙氨酸衍生物的设计、合成及构效关系，作为具有良好抗病毒活性的新型 HIV-1 衣壳抑制剂

期刊:European Journal of Medicinal Chemistry

影响因子:6

doi:10.1016/j.ejmech.2020.112085

Lin Sun, Tianguang Huang, Alexej Dick, Megan E Meuser, Waleed A Zalloum, Chin-Ho Chen, Xiao Ding, Ping Gao, Simon Cocklin, Kuo-Hsiung Lee, Peng Zhan, Xinyong Liu

Composition and Orientation of the Core Region of Novel HIV-1 Entry Inhibitors Influences Metabolic Stability

新型 HIV-1 进入抑制剂核心区域的组成和方向影响代谢稳定性

期刊:Molecules

影响因子:4.2

doi:10.3390/molecules25061430

Rama Karadsheh, Megan E Meuser, Simon Cocklin

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor

基于场的新型氮杂双环己烷支架 HIV-1 进入抑制剂的亲和力优化

期刊:Molecules

影响因子:4.2

doi:10.3390/molecules24081581

Megan E Meuser, Adel A Rashad, Gabriel Ozorowski, Alexej Dick, Andrew B Ward, Simon Cocklin

Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency

新型 HIV-1 进入抑制剂的动力学表征：发现解离率与效力之间的关系

期刊:Molecules

影响因子:4.2

doi:10.3390/molecules23081940

Megan E Meuser, Michael B Murphy, Adel A Rashad, Simon Cocklin

Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic cells

选择性和脑渗透性 ACSS2 抑制剂靶向乳腺癌脑转移细胞

Copper Modulates the Catalytic Activity of Protein Kinase CK2

铜调节蛋白激酶 CK2 的催化活性

Rapid Optimization of the Metabolic Stability of a Human Immunodeficiency Virus Type-1 Capsid Inhibitor Using a Multistep Computational Workflow

使用多步计算工作流程快速优化人类免疫缺陷病毒 1 型衣壳抑制剂的代谢稳定性

Alprazolam Prompts HIV-1 Transcriptional Reactivation and Enhances CTL Response Through RUNX1 Inhibition and STAT5 Activation

阿普唑仑通过抑制 RUNX1 和激活 STAT5 促进 HIV-1 转录再激活并增强 CTL 反应

New RAD51 Inhibitors to Target Homologous Recombination in Human Cells

新型 RAD51 抑制剂靶向人类细胞中的同源重组

Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities

含苯磺酰胺的苯丙氨酸衍生物作为新型HIV-1衣壳抑制剂的设计、合成及机理研究及其抗病毒活性的提高

Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities

4-苯基-1H-1,2,3-三唑苯丙氨酸衍生物的设计、合成及构效关系，作为具有良好抗病毒活性的新型 HIV-1 衣壳抑制剂

Composition and Orientation of the Core Region of Novel HIV-1 Entry Inhibitors Influences Metabolic Stability

新型 HIV-1 进入抑制剂核心区域的组成和方向影响代谢稳定性

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor

基于场的新型氮杂双环己烷支架 HIV-1 进入抑制剂的亲和力优化

Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency

新型 HIV-1 进入抑制剂的动力学表征：发现解离率与效力之间的关系