日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

发现强效、选择性且口服生物可利用的介导复合物相关激酶 CDK8 和 CDK19 的小分子调节剂

Aurélie Mallinger, Kai Schiemann, Christian Rink, Frank Stieber, Michel Calderini, Simon Crumpler, Mark Stubbs, Olajumoke Adeniji-Popoola, Oliver Poeschke, Michael Busch, Paul Czodrowski, Djordje Musil, Daniel Schwarz, Maria-Jesus Ortiz-Ruiz, Richard Schneider, Ching Thai, Melanie Valenti, Alexis de

Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen

通过基于细胞的通路筛选发现有效的、口服生物可利用的 WNT 信号小分子抑制剂

Aurélie Mallinger, Simon Crumpler, Mark Pichowicz, Dennis Waalboer, Mark Stubbs, Olajumoke Adeniji-Popoola, Bozena Wood, Elizabeth Smith, Ching Thai, Alan T Henley, Katrin Georgi, William Court, Steve Hobbs, Gary Box, Maria-Jesus Ortiz-Ruiz, Melanie Valenti, Alexis De Haven Brandon, Robert TePoele, 

Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells

Aurora 异构体选择性:咪唑并[4,5-b]吡啶衍生物的设计和合成作为细胞中 Aurora-A 激酶的高选择性抑制剂

Vassilios Bavetsias, Amir Faisal, Simon Crumpler, Nathan Brown, Magda Kosmopoulou, Amar Joshi, Butrus Atrash, Yolanda Pérez-Fuertes, Jessica A Schmitt, Katherine J Boxall, Rosemary Burke, Chongbo Sun, Sian Avery, Katherine Bush, Alan Henley, Florence I Raynaud, Paul Workman, Richard Bayliss, Spiros

Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)

具有叉头相关和环结构域 (CHFR) 的检查点多锌结合域识别聚(ADP-核糖)的结构基础

Jasmeen Oberoi, Mark W Richards, Simon Crumpler, Nathan Brown, Julian Blagg, Richard Bayliss