日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The inhibition of YAP Signaling Prevents Chronic Biliary Fibrosis in the Abcb4-/- Model by Modulation of Hepatic Stellate Cell and Bile Duct Epithelium Cell Pathophysiology

YAP 信号抑制可通过调节肝星状细胞和胆管上皮细胞病理生理学来预防 Abcb4-/- 模型中的慢性胆道纤维化

Liangtao Ye, Andreas Ziesch, Julia S Schneider, Andrea Ofner, Hanno Nieß, Gerald Denk, Simon Hohenester, Doris Mayr, Ujjwal M Mahajan, Stefan Munker, Najib Ben Khaled, Ralf Wimmer, Alexander L Gerbes, Julia Mayerle, Yulong He, Andreas Geier, Enrico N De Toni, Changhua Zhang, Florian P Reiter

The acidic microenvironment in the perisinusoidal space critically determines bile salt-induced activation of hepatic stellate cells

窦周空间的酸性微环境关键决定了胆汁盐诱导的肝星状细胞的活化

Jingguo Li, Shun Yao, Sebastian Zimny, Dennis Koob, Hai Jin, Ralf Wimmer, Gerald Denk, Biguang Tuo #, Simon Hohenester #

p70 Ribosomal Protein S6 Kinase Is a Checkpoint of Human Hepatic Stellate Cell Activation and Liver Fibrosis in Mice

p70 核糖体蛋白 S6 激酶是人类肝星状细胞活化和小鼠肝纤维化的检查点

Florian P Reiter, Liangtao Ye, Andrea Ofner, Tobias S Schiergens, Andreas Ziesch, Lydia Brandl, Najib Ben Khaled, Simon Hohenester, Ralf Wimmer, Renate Artmann, Yulong He, Serene M L Lee, Doris Mayr, Changhua Zhang, Alexander L Gerbes, Julia Mayerle, Gerald Denk, Enrico N De Toni

Hydrophobic Bile Salts Induce Pro-Fibrogenic Proliferation of Hepatic Stellate Cells through PI3K p110 Alpha Signaling

疏水性胆汁盐通过 PI3K p110 Alpha 信号诱导肝星状细胞促纤维化增殖

Sebastian Zimny, Dennis Koob, Jingguo Li, Ralf Wimmer, Tobias Schiergens, Jutta Nagel, Florian Paul Reiter, Gerald Denk, Simon Hohenester

Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis

甘氨鹅去氧胆酸促进肝细胞性胆汁淤积小鼠肝纤维化

Simon Hohenester, Veronika Kanitz, Andreas E Kremer, Coen C Paulusma, Ralf Wimmer, Helen Kuehn, Gerald Denk, David Horst, Ronald Oude Elferink, Ulrich Beuers

Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut

Nlrp3 依赖性 IL-1β 抑制肠道中的 CD103+ 树突状细胞分化

Rachel Mak'Anyengo, Peter Duewell, Cornelia Reichl, Christine Hörth, Hans-Anton Lehr, Sandra Fischer, Thomas Clavel, Gerald Denk, Simon Hohenester, Sebastian Kobold, Stefan Endres, Max Schnurr, Christian Bauer

Data on chow, liver tissue and mitochondrial fatty acid compositions as well as mitochondrial proteome changes after feeding mice a western diet for 6-24 weeks

给小鼠喂食西方饮食 6-24 周后,食物、肝脏组织和线粒体脂肪酸组成以及线粒体蛋白质组变化的数据

Claudia Einer, Simon Hohenester, Ralf Wimmer, Lena Wottke, Renate Artmann, Sabine Schulz, Christian Gosmann, Alisha Simmons, Christin Leitzinger, Carola Eberhagen, Sabine Borchard, Sabine Schmitt, Stefanie M Hauck, Christine von Toerne, Martin Jastroch, Ellen Walheim, Christian Rust, Alexander L Ger

Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells

磷脂酰肌醇-3-激酶 p110γ 促进胆汁盐诱导的大鼠原代肝细胞和人肝癌细胞凋亡

Simon Hohenester, Anna Gates, Ralf Wimmer, Ulrich Beuers, M Sawkat Anwer, Christian Rust, Cynthia R L Webster

cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytes

通过 Src 酪氨酸激酶激活大鼠肝细胞中的磷酸肌醇-3-激酶 p110 beta/alpha 实现 cAMP-GEF 细胞保护

Anna Gates, Simon Hohenester, M Sawkat Anwer, Cynthia R L Webster