日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression

一个古老分化的 RNA 结合蛋白家族通过隐秘的剪接位点抑制来维持一类超长外显子的正确剪接

Chileleko Siachisumo #, Sara Luzzi #, Saad Aldalaqan #, Gerald Hysenaj, Caroline Dalgliesh, Kathleen Cheung, Matthew R Gazzara, Ivaylo D Yonchev, Katherine James, Mahsa Kheirollahi Chadegani, Ingrid E Ehrmann, Graham R Smith, Simon J Cockell, Jennifer Munkley, Stuart A Wilson, Yoseph Barash, David J

Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves

空间转录组学揭示胚胎人类动脉瓣膜重塑过程中的新基因

Rachel Queen, Moira Crosier, Lorraine Eley, Janet Kerwin, Jasmin E Turner, Jianshi Yu, Ahlam Alqahtani, Tamilvendhan Dhanaseelan, Lynne Overman, Hannah Soetjoadi, Richard Baldock, Jonathan Coxhead, Veronika Boczonadi, Alex Laude, Simon J Cockell, Maureen A Kane, Steven Lisgo, Deborah J Henderson

Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis

治疗波长的紫外线 B 辐射可激活银屑病表皮中的细胞凋亡、昼夜节律、氧化还原信号和关键典型通路

Rachel Addison, Sophie C Weatherhead, Anandika Pawitri, Graham R Smith, Ashley Rider, Henry J Grantham, Simon J Cockell, Nick J Reynolds

Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis

Pax9 是心血管发育所必需的,并与咽内胚层中的 Tbx1 相互作用,控制第四咽弓动脉的形态发生

Helen M Phillips, Catherine A Stothard, Wasay M Shaikh Qureshi, Anastasia I Kousa, J Alberto Briones-Leon, Ramada R Khasawneh, Chloe O'Loughlin, Rachel Sanders, Silvia Mazzotta, Rebecca Dodds, Kerstin Seidel, Timothy Bates, Mitsushiro Nakatomi, Simon J Cockell, Jürgen E Schneider, Timothy J Mohun, R

B-cell activity markers are associated with different disease activity domains in primary Sjögren's syndrome

细胞活性标记与原发性干燥综合征的不同疾病活动域相关

Katherine James, Chimwemwe Chipeta, Antony Parker, Stephen Harding, Simon J Cockell, Colin S Gillespie, Jennifer Hallinan, Francesca Barone, Simon J Bowman, Wan-Fai Ng, Benjamin A Fisher; UK Primary Sjögren’s Syndrome Registry

SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing

SIRT1 影响多梳蛋白组靶基因的 DNA 甲基化,这是衰老过程中观察到的表观遗传转变的热点

Luisa A Wakeling, Laura J Ions, Suzanne M Escolme, Simon J Cockell, Tianhong Su, Madhurima Dey, Emily V Hampton, Gail Jenkins, Linda J Wainwright, Jill A McKay, Dianne Ford

Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies

B-13 祖细胞衍生肝细胞在肝毒性和遗传毒性研究中的效用

Philip M E Probert, Git W Chung, Simon J Cockell, Loranne Agius, Pasquale Mosesso, Steven A White, Fiona Oakley, Colin D A Brown, Matthew C Wright

Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence

p53 和 Rb 的调节将替代 NF-κB 通路与 EZH2 表达和细胞衰老联系起来

Alessio Iannetti, Adeline C Ledoux, Susan J Tudhope, Hélène Sellier, Bo Zhao, Sophia Mowla, Adam Moore, Holger Hummerich, Benjamin E Gewurz, Simon J Cockell, Parmjit S Jat, Elaine Willmore, Neil D Perkins

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA

MRE11 促进人类拓扑异构酶 II 复合物从基因组 DNA 中去除

Ka Cheong Lee, Kay Padget, Hannah Curtis, Ian G Cowell, Davide Moiani, Zbyslaw Sondka, Nicholas J Morris, Graham H Jackson, Simon J Cockell, John A Tainer, Caroline A Austin