日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer

FOXO1 将 KRAS G12D 和 G12V 等位基因与结直肠癌中的谷氨酰胺和氮代谢联系起来

Suzan Ber,Ming Yang,Marco Sciacovelli,Shamith Samarajiwa,Khushali Patel,Efterpi Nikitopoulou,Annie Howitt,Simon J Cook,Ashok R Venkitaraman  ,Christian Frezza    ,Alessandro Esposito

Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway

用于筛选 KRAS-RAF-MEK1/2-ERK1/2 通路抑制剂或调节剂的报告细胞系

Laura Weatherdon, Kate Stuart, Megan Cassidy, Alberto Moreno de la Gándara, Hanneke Okkenhaug, Markus Muellener, Grahame Mckenzie, Simon J Cook, Rebecca Gilley

The seventh blind test of crystal structure prediction: structure ranking methods

晶体结构预测的第七次盲测:结构排序方法

Hunnisett, Lily M; Francia, Nicholas; Nyman, Jonas; Abraham, Nathan S; Aitipamula, Srinivasulu; Alkhidir, Tamador; Almehairbi, Mubarak; Anelli, Andrea; Anstine, Dylan M; Anthony, John E; Arnold, Joseph E; Bahrami, Faezeh; Bellucci, Michael A; Beran, Gregory J O; Bhardwaj, Rajni M; Bianco, Raffaello; Bis, Joanna A; Boese, A Daniel; Bramley, James; Braun, Doris E; Butler, Patrick W V; Cadden, Joseph; Carino, Stephen; Červinka, Ctirad; Chan, Eric J; Chang, Chao; Clarke, Sarah M; Coles, Simon J; Cook, Cameron J; Cooper, Richard I; Darden, Tom; Day, Graeme M; Deng, Wenda; Dietrich, Hanno; DiPasquale, Antonio; Dhokale, Bhausaheb; van Eijck, Bouke P; Elsegood, Mark R J; Firaha, Dzmitry; Fu, Wenbo; Fukuzawa, Kaori; Galanakis, Nikolaos; Goto, Hitoshi; Greenwell, Chandler; Guo, Rui; Harter, Jürgen; Helfferich, Julian; Hoja, Johannes; Hone, John; Hong, Richard; Hušák, Michal; Ikabata, Yasuhiro; Isayev, Olexandr; Ishaque, Ommair; Jain, Varsha; Jin, Yingdi; Jing, Aling; Johnson, Erin R; Jones, Ian; Jose, K V Jovan; Kabova, Elena A; Keates, Adam; Kelly, Paul F; Klimeš, Jiří; Kostková, Veronika; Li, He; Lin, Xiaolu; List, Alexander; Liu, Congcong; Liu, Yifei Michelle; Liu, Zenghui; Lončarić, Ivor; Lubach, Joseph W; Ludík, Jan; Maryewski, Alexander A; Marom, Noa; Matsui, Hiroyuki; Mattei, Alessandra; Mayo, R Alex; Melkumov, John W; Mladineo, Bruno; Mohamed, Sharmarke; Momenzadeh Abardeh, Zahrasadat; Muddana, Hari S; Nakayama, Naofumi; Nayal, Kamal Singh; Neumann, Marcus A; Nikhar, Rahul; Obata, Shigeaki; O'Connor, Dana; Oganov, Artem R; Okuwaki, Koji; Otero-de-la-Roza, Alberto; Parkin, Sean; Parunov, Antonio; Podeszwa, Rafał; Price, Alastair J A; Price, Louise S; Price, Sarah L; Probert, Michael R; Pulido, Angeles; Ramteke, Gunjan Rajendra; Rehman, Atta Ur; Reutzel-Edens, Susan M; Rogal, Jutta; Ross, Marta J; Rumson, Adrian F; Sadiq, Ghazala; Saeed, Zeinab M; Salimi, Alireza; Sasikumar, Kiran; Sekharan, Sivakumar; Shankland, Kenneth; Shi, Baimei; Shi, Xuekun; Shinohara, Kotaro; Skillman, A Geoffrey; Song, Hongxing; Strasser, Nina; van de Streek, Jacco; Sugden, Isaac J; Sun, Guangxu; Szalewicz, Krzysztof; Tan, Lu; Tang, Kehan; Tarczynski, Frank; Taylor, Christopher R; Tkatchenko, Alexandre; Touš, Petr; Tuckerman, Mark E; Unzueta, Pablo A; Utsumi, Yohei; Vogt-Maranto, Leslie; Weatherston, Jake; Wilkinson, Luke J; Willacy, Robert D; Wojtas, Lukasz; Woollam, Grahame R; Yang, Yi; Yang, Zhuocen; Yonemochi, Etsuo; Yue, Xin; Zeng, Qun; Zhou, Tian; Zhou, Yunfei; Zubatyuk, Roman; Cole, Jason C

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

ERK1/2 抑制剂可作为单价降解剂,诱导 ERK2 泛素化和蛋白酶体依赖性周转,但不诱导 ERK1

Kathryn Balmanno #, Andrew M Kidger #, Dominic P Byrne, Matthew J Sale, Nejma Nassman, Patrick A Eyers, Simon J Cook

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor

药效和药代动力学的并行优化导致发现吡咯酰胺 ERK5 激酶结构域抑制剂

Duncan C Miller, Tristan Reuillon, Lauren Molyneux, Timothy Blackburn, Simon J Cook, Noel Edwards, Jane A Endicott, Bernard T Golding, Roger J Griffin, Ian Hardcastle, Suzannah J Harnor, Amy Heptinstall, Pamela Lochhead, Mathew P Martin, Nick C Martin, Stephanie Myers, David R Newell, Richard A Nobl

IKKα plays a major role in canonical NF-κB signalling in colorectal cells

IKKα 在结直肠细胞的典型 NF-κB 信号传导中起主要作用

Jack A Prescott, Kathryn Balmanno, Jennifer P Mitchell, Hanneke Okkenhaug, Simon J Cook

Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors

ERK5 激酶抑制剂对蛋白激酶转录因子 ERK5 的反常激活

Pamela A Lochhead, Julie A Tucker, Natalie J Tatum, Jinhua Wang, David Oxley, Andrew M Kidger, Victoria P Johnson, Megan A Cassidy, Nathanael S Gray, Martin E M Noble, Simon J Cook

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

mTORC1 到 CDK1 的转换在有丝分裂期间维持自噬抑制

Richard I Odle, Simon A Walker, David Oxley, Andrew M Kidger, Kathryn Balmanno, Rebecca Gilley, Hanneke Okkenhaug, Oliver Florey, Nicholas T Ktistakis, Simon J Cook

AAV Targeting of Glial Cell Types in the Central and Peripheral Nervous System and Relevance to Human Gene Therapy

AAV靶向中枢和周围神经系统中的胶质细胞类型及其与人类基因治疗的相关性

O'Carroll, Simon J; Cook, William H; Young, Deborah

Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

针对黑色素瘤的 MCL1 偏向释放了 BRAF 和 ERK1/2 通路抑制剂的凋亡潜力

Matthew J Sale, Emma Minihane, Noel R Monks, Rebecca Gilley, Frances M Richards, Kevin P Schifferli, Courtney L Andersen, Emma J Davies, Mario Aladren Vicente, Eiko Ozono, Aleksandra Markovets, Jonathan R Dry, Lisa Drew, Vikki Flemington, Theresa Proia, Duncan I Jodrell, Paul D Smith, Simon J Cook