日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Improvements in large-scale production of tobacco etch virus protease

烟草蚀纹病毒蛋白酶大规模生产的改进

Simon Messing ,Kirsten Barnhart ,Matthew Drew ,Natalie Granato-Guerrero ,Carissa Grose ,Brianna Higgins ,Min Hong ,Jenna Hull ,Shelley Perkins ,Ivy Poon ,Nitya Ramakrishnan ,Amanda Seabolt ,Troy Taylor ,Vanessa E Wall ,Nicholas Wright ,William Gillette ,Dominic Esposito

Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties

KRAS4a 和 KRAS4b 剪接变体的比较分析揭示了它们独特的结构和功能特性。

Matthew J Whitley ,Timothy H Tran ,Megan Rigby ,Ming Yi ,Srisathiyanarayanan Dharmaiah ,Timothy J Waybright ,Nitya Ramakrishnan ,Shelley Perkins ,Troy Taylor ,Simon Messing ,Dominic Esposito ,Dwight V Nissley ,Frank McCormick ,Andrew G Stephen ,Thomas Turbyville ,Gabriel Cornilescu ,Dhirendra K Simanshu

RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy

致病性RIT1介导的RAS依赖性RAF-MAPK过度激活是Noonan综合征相关心脏肥大的治疗靶点。

Antonio Cuevas-Navarro ,Morgan Wagner ,Richard Van ,Monalisa Swain ,Stephanie Mo ,John Columbus ,Madeline R Allison ,Alice Cheng ,Simon Messing ,Thomas J Turbyville ,Dhirendra K Simanshu ,Matthew J Sale ,Frank McCormick ,Andrew G Stephen ,Pau Castel

Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome

SHOC2-MRAS-PP1C 复合物的结构为 RAF 激活和 Noonan 综合征提供了见解

Daniel A Bonsor, Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing, Lorenzo I Finci, Dwight V Nissley, Frank McCormick, Dominic Esposito, Pablo Rodriguez-Viciana, Andrew G Stephen, Dhirendra K Simanshu

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

KRAS 与 RAF1 RAS 结合域和富含半胱氨酸域的相互作用为 RAS 介导的 RAF 激活提供了见解

Timothy H Tran #, Albert H Chan #, Lucy C Young #, Lakshman Bindu, Chris Neale, Simon Messing, Srisathiyanarayanan Dharmaiah, Troy Taylor, John-Paul Denson, Dominic Esposito, Dwight V Nissley, Andrew G Stephen, Frank McCormick, Dhirendra K Simanshu

Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer

生化和结构分析表明,肿瘤抑制因子神经纤维蛋白(NF1)形成高亲和力二聚体

Mukul Sherekar, Sae-Won Han, Rodolfo Ghirlando, Simon Messing, Matthew Drew, Dana Rabara, Timothy Waybright, Puneet Juneja, Hugh O'Neill, Christopher B Stanley, Debsindhu Bhowmik, Arvind Ramanathan, Sriram Subramaniam, Dwight V Nissley, William Gillette, Frank McCormick, Dominic Esposito

Anionic Lipids Impact RAS-Binding Site Accessibility and Membrane Binding Affinity of CRAF RBD-CRD

阴离子脂质影响 CRAF RBD-CRD 的 RAS 结合位点可及性和膜结合亲和力

Timothy Travers, Cesar A López, Constance Agamasu, Jeevapani J Hettige, Simon Messing, Angel E García, Andrew G Stephen, S Gnanakaran

Standardization of enzyme-linked immunosorbent assays for serosurveys of the SARS-CoV-2 pandemic using clinical and at-home blood sampling

使用临床和家庭血液采样对 SARS-CoV-2 大流行血清调查的酶联免疫吸附试验进行标准化

Carleen Klumpp-Thomas, Heather Kalish, Matthew Drew, Sally Hunsberger, Kelly Snead, Michael P Fay, Jennifer Mehalko, Anandakumar Shunmugavel, Vanessa Wall, Peter Frank, John-Paul Denson, Min Hong, Gulcin Gulten, Simon Messing, Jennifer Hicks, Sam Michael, William Gillette, Matthew D Hall, Matthew Me

Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane

定量生物物理分析确定了调节 GTPase KRAS 募集到质膜的关键成分

Bindu Lakshman, Simon Messing, Eva M Schmid, Jeffrey D Clogston, William K Gillette, Dominic Esposito, Bailey Kessing, Daniel A Fletcher, Dwight V Nissley, Frank McCormick, Andrew G Stephen, Frantz L Jean-Francois

Structures of N-terminally processed KRAS provide insight into the role of N-acetylation

端加工的 KRAS 结构有助于深入了解 N 乙酰化的作用

Srisathiyanarayanan Dharmaiah, Timothy H Tran, Simon Messing, Constance Agamasu, William K Gillette, Wupeng Yan, Timothy Waybright, Patrick Alexander, Dominic Esposito, Dwight V Nissley, Frank McCormick, Andrew G Stephen, Dhirendra K Simanshu