日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Clonal tracing with somatic epimutations reveals dynamics of blood ageing

利用体细胞表观突变进行克隆追踪揭示血液衰老的动态过程

Michael Scherer # ,Indranil Singh # ,Martina Maria Braun # ,Chelsea Szu-Tu # ,Pedro Sanchez Sanchez ,Dominik Lindenhofer ,Niels Asger Jakobsen ,Verena Körber ,Michael Kardorff ,Lena Nitsch ,Pauline Kautz ,Julia Rühle ,Agostina Bianchi ,Luca Cozzuto ,Robert Frömel ,Sergi Beneyto-Calabuig ,Caleb Lareau ,Ansuman T Satpathy ,Renée Beekman ,Lars M Steinmetz ,Simon Raffel ,Leif S Ludwig ,Paresh Vyas ,Alejo Rodriguez-Fraticelli ,Lars Velten

Proteasome inhibition enhances the anti-leukemic efficacy of chimeric antigen receptor (CAR) expressing NK cells against acute myeloid leukemia

蛋白酶体抑制增强了表达嵌合抗原受体(CAR)的NK细胞对急性髓系白血病的抗白血病疗效。

David Sedloev,Qian Chen,Julia M Unglaub,Nicola Schanda,Yao Hao,Eleni Besiridou,Brigitte Neuber,Anita Schmitt,Simon Raffel,Yi Liu,Maike Janssen,Carsten Müller-Tidow,Michael Schmitt,Tim Sauer

Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan

体细胞表观突变使得在小鼠和人类生命周期内进行原生造血的单细胞谱系追踪成为可能

Michael Scherer, Indranil Singh, Martina Braun, Chelsea Szu-Tu, Michael Kardorff, Julia Rühle, Robert Frömel, Sergi Beneyto-Calabuig, Simon Raffel, Alejo Rodriguez-Fraticelli, Lars Velten

Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

急性髓系白血病干细胞中 BCL2 家族的组合表达可预测阿扎胞苷/维奈托克治疗的临床疗效

Alexander Waclawiczek # ,Aino-Maija Leppä # ,Simon Renders # ,Karolin Stumpf # ,Cecilia Reyneri # ,Barbara Betz # ,Maike Janssen ,Rabia Shahswar ,Elisa Donato ,Darja Karpova ,Vera Thiel ,Julia M Unglaub ,Susanna Grabowski ,Stefanie Gryzik ,Lisa Vierbaum ,Richard F Schlenk ,Christoph Röllig ,Michael Hundemer ,Caroline Pabst ,Michael Heuser ,Simon Raffel ,Carsten Müller-Tidow ,Tim Sauer # ,Andreas Trumpp #

A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia

动态的rRNA核糖甲基化组驱动急性髓系白血病干性

Fengbiao Zhou # ,Nesrine Aroua # ,Yi Liu ,Christian Rohde ,Jingdong Cheng ,Anna-Katharina Wirth ,Daria Fijalkowska ,Stefanie Göllner ,Michelle Lotze ,Haiyang Yun ,Xiaobing Yu ,Caroline Pabst ,Tim Sauer ,Thomas Oellerich ,Hubert Serve ,Christoph Röllig ,Martin Bornhäuser ,Christian Thiede ,Claudia Baldus ,Michaela Frye ,Simon Raffel ,Jeroen Krijgsveld ,Irmela Jeremias ,Roland Beckmann ,Andreas Trumpp ,Carsten Müller-Tidow

The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia

核糖体蛋白S6激酶α-1 (RPS6KA1) 可诱导急性髓系白血病对维奈托克/阿扎胞苷产生耐药性。

Katharina Weidenauer # ,Christina Schmidt # ,Christian Rohde ,Cornelius Pauli ,Maximilian F Blank ,Daniel Heid ,Alexander Waclawiczek ,Anika Corbacioglu ,Stefanie Göllner ,Michelle Lotze ,Lisa Vierbaum ,Simon Renders ,Jeroen Krijgsveld ,Simon Raffel ,Tim Sauer ,Andreas Trumpp ,Caroline Pabst ,Carsten Müller-Tidow ,Maike Janssen

Antigen presentation safeguards the integrity of the hematopoietic stem cell pool

抗原呈递保障造血干细胞库的完整性

Pablo Hernández-Malmierca ,Dominik Vonficht ,Alexandra Schnell ,Hannah J Uckelmann ,Alina Bollhagen ,Mohamed A A Mahmoud ,Sophie-Luise Landua ,Elise van der Salm ,Christine L Trautmann ,Simon Raffel ,Florian Grünschläger ,Raphael Lutz ,Michael Ghosh ,Simon Renders ,Nádia Correia ,Elisa Donato ,Karin O Dixon ,Christoph Hirche ,Carolin Andresen ,Claudia Robens ,Paula S Werner ,Tobias Boch ,David Eisel ,Wolfram Osen ,Franziska Pilz ,Adriana Przybylla ,Corinna Klein ,Frank Buchholz ,Michael D Milsom ,Marieke A G Essers ,Stefan B Eichmüller ,Wolf-Karsten Hofmann ,Daniel Nowak ,Daniel Hübschmann ,Michael Hundemer ,Christian Thiede ,Lars Bullinger ,Carsten Müller-Tidow ,Scott A Armstrong ,Andreas Trumpp ,Vijay K Kuchroo ,Simon Haas

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

造血系统的单细胞蛋白质基因组参考图谱能够纯化和大规模分析精确定义的细胞状态

Sergio Triana #,Dominik Vonficht #,Lea Jopp-Saile #,Simon Raffel,Raphael Lutz,Daniel Leonce,Magdalena Antes,Pablo Hernández-Malmierca,Diana Ordoñez-Rueda,Beáta Ramasz,Tobias Boch,Johann-Christoph Jann,Daniel Nowak,Wolf-Karsten Hofmann,Carsten Müller-Tidow,Daniel Hübschmann,Theodore Alexandrov,Vladimir Benes,Andreas Trumpp,Malte Paulsen,Lars Velten,Simon Haas

Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells

糖原积累、中心碳代谢和造血干细胞和祖细胞的衰老

Laura Poisa-Beiro #, Judith Thoma #, Jonathan Landry, Sven Sauer, Akihisa Yamamoto, Volker Eckstein, Natalie Romanov, Simon Raffel, Georg F Hoffmann, Peer Bork, Vladimir Benes, Anne-Claude Gavin, Motomu Tanaka, Anthony D Ho4

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

NKG2D 配体的缺失定义了白血病干细胞并介导其免疫逃避

Anna M Paczulla #, Kathrin Rothfelder #, Simon Raffel #, Martina Konantz, Julia Steinbacher, Hui Wang, Claudia Tandler, Marcelle Mbarga, Thorsten Schaefer, Mattia Falcone, Eva Nievergall, Daniela Dörfel, Pauline Hanns, Jakob R Passweg, Christoph Lutz, Juerg Schwaller, Robert Zeiser, Bruce R Blazar,