Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe
对 14,002 名个体的 LRRK2 基因进行深度测序,揭示了纯化选择的证据,并表明 p.Arg1628Pro 突变在欧洲具有独立起源。
期刊:Human Mutation
影响因子:3.7
doi:10.1002/humu.22075
Rubio, Justin P; Topp, Simon; Warren, Liling; St Jean, Pamela L; Wegmann, Daniel; Kessner, Darren; Novembre, John; Shen, Judong; Fraser, Dana; Aponte, Jennifer; Nangle, Keith; Cardon, Lon R; Ehm, Margaret G; Chissoe, Stephanie L; Whittaker, John C; Nelson, Matthew R; Mooser, Vincent E